Pharmaceutical Company Executive
Internal Medicine
David W. Bilheimer
David Bilheimer practices Internal Medicine. He studied medicine at Perelman School of Medicine at the University of Pennsylvania. He received 1 awards: "Elected Member". David Bilheimer is a published MD. He published 67 publications, including: 'Should separate endpoint trials be required for all lipid-lowering drugs acting by the same mechanism?'
Publications
- Task force 2: Investigator participation in clinical research.
- Heart-liver transplantation in a patient with familial hypercholesterolaemia.
- Familial hypercholesterolemia with "normal" cholesterol in obligate heterozygotes.
- Familial hypercholesterolemia. There is a need for early detection and treatment.
- The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations.
- On the apoprotein composition of human plasma very low density lipoprotein subfractions.
- Portacaval shunt surgery and liver transplantation in the treatment of homozygous familial hypercholesterolemia.
- Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.
- On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein.
- The metabolism of very low density lipoprotein proteins. II. Studies on the transfer of apoproteins between plasma lipoproteins.
- Should separate endpoint trials be required for all lipid-lowering drugs acting by the same mechanism?
- Role of receptor-independent low density lipoprotein transport in the maintenance of tissue cholesterol balance in the normal and WHHL rabbit.
- Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.
- Inverse relation between low-density lipoprotein-cholesterol and dehydroisoandrosterone sulfate in human fetal plasma.
- Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes.
- Clinical considerations regarding treatment of hypercholesterolemia in the elderly.
- Metabolic effects of portacaval shunt surgery and liver transplantation in familial hypercholesterolemia.
- The lipoprotein receptor concept.
- Lipoprotein fractions and receptors: a role for probucol?
- Portacaval shunt and liver transplantation in treatment of familial hypercholesterolemia.
- Regulation of LDL receptors in vivo.
- Rationale of the diet-heart statement of the American Heart Association. Report of Nutrition Committee.
- The role of the LDL receptor in lipoprotein metabolism.
- Cholesterol education implications for clinical practice.
- Fatty acid accumulation and abnormal lipid deposition in peripheral and border zones of experimental myocardial infarcts.
- Metabolic studies in familial hypercholesterolemia. Evidence for a gene-dosage effect in vivo.
- Clinical studies in a kindred with a kinetic LDL receptor mutation causing familial hypercholesterolemia.
- Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits.
- Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes.
- Treatment of refractory familial hypercholesterolemia by low-density lipoprotein apheresis using an automated dextran sulfate cellulose adsorption system. The Liposorb...
- Long-term clinical tolerance of lovastatin and simvastatin.
- Detection of familial hypercholesterolemia by assaying functional low-density-lipoprotein receptors on lymphocytes.
- Impaired receptor-mediated catabolism of low density lipoprotein in the WHHL rabbit, an animal model of familial hypercholesterolemia.
- An overview: long-term tolerability of lovastatin and simvastatin.
- Treatment of children with homozygous familial hypercholesterolemia: safety and efficacy of low-density lipoprotein apheresis.
- Therapeutic control of hyperlipidemia in the prevention of coronary atherosclerosis: a review of results from recent clinical trials.
- Impaired catabolism of very low-density lipoprotein-triglyceride in a family with primary hypertriglyceridemia.
- Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age.
- The effect of diabetic control on very low-density lipoprotein--triglyceride metabolism in patients with type II diabetes mellitus and marked hypertriglyceridemia.
- Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.
- Pathobiology of human familial hypercholesterolaemia and a related animal model, the Watanabe heritable hyperlipidaemic rabbit.
- Failure of a slow channel calcium antagonist, verapamil, to retard atherosclerosis in the Watanabe heritable hyperlipidemic rabbit: an animal model of familial hyperch...
- Studied of very low density lipoprotein triglyceride metabolism in an obese population with low plasma lipids: lack of influence of body weight or plasma insulin.
- Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.
- Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
- Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes. Comparison of cells from normal subjects and patients with homozygous fam...
- Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.
- Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.
- The role of lipid regulation in the prevention of coronary heart disease.
- Preliminary report: treatment of type 3 hyperlipoproteinemia with mevinolin.
- Combination drug therapy for familial combined hyperlipidemia.
- Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.
- Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.
- Liver transplantation to provide low-density-lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia.
- The low density lipoprotein receptor in Xenopus laevis. II. Feedback repression mediated by conserved sterol regulatory element.
- Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.
- Influence of combined therapy with mevinolin and interruption of bile-acid reabsorption on low density lipoproteins in heterozygous familial hypercholesterolemia.
- Mevinolin stimulates receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.
- Normal cholesterol levels with lovastatin (mevinolin) therapy in a child with homozygous familial hypercholesterolemia following liver transplantation.
- The A-to-Z Trial: Methods and rationale for a single trial investigating combined use of low-molecular-weight heparin with the glycoprotein IIb/IIIa inhibitor tirofiba...
- Efficacy and safety of simvastatin in Asian and non-Asian coronary heart disease patients: a comparison of the GOALLS and STATT studies.
- Safety and efficacy of enoxaparin vs unfractionated heparin in patients with non-ST-segment elevation acute coronary syndromes who receive tirofiban and aspirin: a ran...
- Enoxaparin versus unfractionated heparin in patients treated with tirofiban, aspirin and an early conservative initial management strategy: results from the A phase of...
- Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial.
- Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial.
- Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983.
Schools
Perelman School of Medicine University of Pennsylvania
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
-
Perelman School of Medicine at the University of Pennsylvania
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