Physician
Endocrinology
Dr. Abba J. Kastin, MD
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Abba Kastin works in the field of Endocrinology. He received awards:"Whos Who in Medicine and Healthcare" and "Fellow (FACE)". Dr. Abba J. Kastin has written publications. He has 102 publications published with PubMed. The lastest publication is: 'Neuropeptides and the blood-brain barrier in goldfish.'
Publications
- Sleep fragmentation has differential effects on obese and lean mice.
- Role of Astrocytes in Leptin Signaling.
- Can sleep apnea cause Alzheimer's disease?
- Sleep restriction impairs blood-brain barrier function.
- Increased sleep fragmentation in experimental autoimmune encephalomyelitis.
- Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.
- Diet-induced obesity suppresses expression of many proteins at the blood-brain barrier.
- Leptin: A biomarker for sleep disorders?
- Hypersomnolence and Reduced Activity in Pan-Leptin Receptor Knockout Mice.
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.
- Saturable Leptin Transport Across the BBB Persists in EAE Mice.
- Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis.
- Astrocytic leptin-receptor knockout mice show partial rescue of leptin resistance in diet-induced obesity.
- Protective role of astrocytic leptin signaling against excitotoxicity.
- Endothelial cell leptin receptor mutant mice have hyperleptinemia and reduced tissue uptake.
- Brain interleukin-15 in neuroinflammation and behavior.
- Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis.
- Leptin action on nonneuronal cells in the CNS: potential clinical applications.
- Cytokine Signaling Modulates Blood-Brain Barrier Function.
- Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.
- Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice.
- Potential protective role of IL15Rα during inflammation.
- Essential role of interleukin-15 receptor in normal anxiety behavior.
- Unique leptin trafficking by a tailless receptor.
- IL-15 receptor deletion results in circadian changes of locomotor and metabolic activity.
- Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.
- Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier.
- Leptin receptor mRNA in rat brain astrocytes.
- The Cdk5/p35 kinases modulate leptin-induced STAT3 signaling.
- Cessation of blood-to-brain influx of interleukin-15 during development of EAE.
- Mass spectrometric quantification of MIF-1 in mouse brain by multiple reaction monitoring.
- Commentaries on viewpoint: effect of altitude on leptin, does it go up or down?
- A diffusion barrier between the area postrema and nucleus tractus solitarius.
- Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice.
- Neuroinflammation facilitates LIF entry into brain: role of TNF.
- Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport.
- Increased leptin permeation across the blood-brain barrier after chronic alcohol ingestion.
- Soluble receptor inhibits leptin transport.
- Peptides and hormesis.
- The fasting polypeptide FGF21 can enter brain from blood.
- From MIF-1 to endomorphin: the Tyr-MIF-1 family of peptides.
- Nesfatin-1 crosses the blood-brain barrier without saturation.
- TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression.
- Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd.
- Adipokines and the blood-brain barrier.
- Corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 are both trafficking and signaling receptors for urocortin.
- Opposing effects of proteasomes and lysosomes on LIFR: modulation by TNF.
- Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity.
- Urocortin trafficking in cerebral microvessel endothelial cells.
- Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke.
- Permeation of hepatocyte growth factor across the blood-brain barrier.
- Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier.
- Intranasal leptin: blood-brain barrier bypass (BBBB) for obesity?
- Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin.
- Stroke upregulates TNFalpha transport across the blood-brain barrier.
- Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting.
- Permeation of growth hormone across the blood-brain barrier.
- Effects of peptides, with emphasis on feeding, pain, and behavior A 5-year (1999-2003) review of publications in Peptides.
- Twenty-five years of peptides.
- Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier.
- Circulating TGF-beta1 does not cross the intact blood-brain barrier.
- Novel peptide-peptide cooperation may transform feeding behavior.
- Antibodies to beta-amyloid decrease the blood-to-brain transfer of beta-amyloid peptide.
- Differential antagonism of endomorphin-1 and endomorphin-2 supraspinal antinociception by naloxonazine and 3-methylnaltrexone.
- TNFalpha transport across the blood-brain barrier is abolished in receptor knockout mice.
- Endomorphins, Met-enkephalin, Tyr-MIF-1, and the P-glycoprotein efflux system.
- Selected contribution: circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord.
- Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier.
- Upregulation of the transport system for TNFalpha at the blood-brain barrier.
- Neonatal administration of beta-endorphin produces "chronic" insensitivity to thermal stimuli.
- The present concept of the nature of hypothalamic hormones stimulating and inhibiting the release of pituitary hormones.
- Endomorphin-2 immunoreactivity in the cervical dorsal horn of the rat spinal cord at the electron microscopic level.
- Additional evidence that small amounts of a peptide can cross the blood-brain barrier.
- Activity and specificity of synthetic thyrotropin-releasing hormone in man.
- Electron microscopic examination of the endomorphin 2-like immunoreactive neurons in the rat hypothalamus.
- Hypothalamic hormones: the link between brain and body.
- Purification of hypothalamic releasing hormones of human origin.
- Feeding peptides interact in several ways with the blood-brain barrier.
- Regional in vitro uptake of a synthetic 3H-labeled-melanin into rat brain.
- Synthetic thyrotropin-releasing hormone. A potent stimulator of thyrotropin secretion in man.
- Entry of exendin-4 into brain is rapid but may be limited at high doses.
- Breakdown of enkephalin and endorphin analogs by brain extracts.
- Isolation and structure of another hypothalamic peptide possessing MSH-release-inhibiting activity.
- Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat.
- Degradation of delta sleep inducing peptide (DSIP) and its analogs by brain extracts.
- Neuroendocrine influence on attention and memory.
- Dynamic regulation of leptin entry into brain by the blood-brain barrier.
- Effects of endorphin and enkephalin analogs on fear habituation in goldfish.
- Effect of melanocyte-stimulating hormone on the cortical somatic evoked responses in man.
- Interactions of IGF-1 with the blood-brain barrier in vivo and in situ.
- Increased analgesic activities of a fluorinated and a dimeric analogue of [D-Ala-2]-methionine enkephalinamide.
- Anovulatory uterine bleeding after administration of MSH to women with secondary amenorrhoea.
- Differential antagonism of endomorphin-1 and endomorphin-2 spinal antinociception by naloxonazine and 3-methoxynaltrexone.
- Disapearance and excretion of labeled alpha-MSH in man.
- Oxotremorine antagonism by a hypothalamic hormone, melanocyte-stimulating hormone release-inhibiting factor (MIF).
- Differential transport of rat and human interleukin-1alpha across the blood-brain barrier and blood-testis barrier in rats.
- Enkephalin and other peptides reduce passiveness.
- Interactions between pineal, hypothalamus, and pituitary involving melatonin, MSH release-inhibiting factor and MSH.
- Agouti-related protein(83-132) aggregates and crosses the blood-brain barrier slowly.
- Neuropeptides and the blood-brain barrier in goldfish.
- The Blood-Brain Barrier: Regulatory Roles in Wakefulness and Sleep.
Schools
Harvard Medical School
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Whos Who in Medicine and Healthcare
- Fellow (FACE)
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