A Thomas Look, MD Vice Chair for Research Dept of Pediatric Oncology Dana-Farber Cancer Institute Professor of Pediatrics Harvard Medical School
Pediatric Hematology & Oncology
Dr. Alfred T. Look Jr., MD
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Alfred Look works in the field of Pediatric Hematology & Oncology. He attended University of Michigan Medical School. He received awards:"Fellow of AAAS Award", "The Scotts Company Pediatric Research Fellowship Award", "ASPHO Frank A. Oski Memorial Lectureship Award", "5th Annual Ian Peter Rennert Lectureship Award", "Award for Excellence", "Allison Eberlein Award" and "Elected Member". Alfred T. Look Jr., MD is a published doctor. He published 16 publications, including: 'The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.'
Publications
- The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.
- A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing.
- Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia.
- An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
- L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way.
- Cyclin C is a haploinsufficient tumour suppressor.
- Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells.
- Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia.
- Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish.
- Notch signaling: switching an oncogene to a tumor suppressor.
- c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
- Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia.
- BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more differentiated T-ALL cell lines.
- Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.
- The Chromatin Remodeling Factor CHD5 Is a Transcriptional Repressor of WEE1.
Schools
University of Mi Med Sch
Mich
St Jude Chldns Rsch Hospital
Doctors Specialties
- Pediatric Hematology
- Oncology
Accepted Insurances
Awards
- Fellow of AAAS Award
- The Scotts Company Pediatric Research Fellowship Award
- ASPHO Frank A. Oski Memorial Lectureship Award
- 5th Annual Ian Peter Rennert Lectureship Award
- Award for Excellence
- Allison Eberlein Award
- Elected Member
Education
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University of Michigan Hospitals and Health Centers -
University of Michigan Medical School
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