Professor, Internal Medicine, University of Texas Medical Branch SOM
Endocrinology
Dr. Allan R. Brasier, MD
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Allan Brasier is an expert in the field of Endocrinology. He researched medicine at University of California San Francisco School of Medicine. University of California San Francisco School of Medicine is a top medical college. University of California San Francisco School of Medicine has a rank of 3 in research and a 3 in primary care He has 1 awards "Elected Member". Allan Brasier is a published doctor. He published 101 publications, including: 'Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.'
Publications
- Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.
- Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2.
- Endothelial cell proteomic response to Rickettsia conorii infection reveals activation of the Jak-STAT-ISG15 pathway and reprogramming plasma membrane integrin/cadheri...
- Whole transcriptome analysis reveals an 8-oxoguanine DNA glycosylase-1-driven DNA repair-dependent gene expression linked to essential biological processes.
- Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection.
- Molecular classification of outcomes from dengue virus -3 infections.
- The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome.
- Evolution of Multidisciplinary Translational Teams (MTTs): Insights for Accelerating Translational Innovations.
- Unlocking proteomic heterogeneity in complex diseases through visual analytics.
- Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1-KRAS-NF-κB Pathway.
- Complement C5-inhibitor rEV576 (coversin) ameliorates in-vivo effects of antiphospholipid antibodies.
- TLR4 Activation Enhances the PD-L1-Mediated Tolerogenic Capacity of Colonic CD90+ Stromal Cells.
- ATM regulates NF-κB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
- Multiplexed Parallel Reaction Monitoring Targeting Histone Modifications on the QExactive Mass Spectrometer.
- Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis.
- 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization.
- Assessing and evaluating multidisciplinary translational teams: a mixed methods approach.
- 8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.
- IL-6 regulates extracellular matrix remodeling associated with aortic dilation in a fibrillin-1 hypomorphic mgR/mgR mouse model of severe Marfan syndrome.
- Modulation of Gene Expression Regulated by the Transcription Factor NF-κB/RelA.
- Identification of innate immune response endotypes in asthma: implications for personalized medicine.
- Innate immune response to arenaviral infection: A focus on the highly pathogenic New World hemorrhagic arenaviruses.
- Aortic Remodeling After Transverse Aortic Constriction in Mice Is Attenuated With AT1 Receptor Blockade.
- Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interle...
- Use of theoretical Peptide distributions in phosphoproteome analysis.
- Quantitation of the dynamic profiles of the innate immune response using multiplex selected reaction monitoring-mass spectrometry.
- Applications Of Selected Reaction Monitoring (SRM)-Mass Spectrometry (MS) For Quantitative Measurement Of Signaling Pathways.
- The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams.
- A structured approach to predictive modeling of a two-class problem using multidimensional data sets.
- The IL-6 Trans-Signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar.
- JunÃÂn virus pathogenesis and virus replication.
- Strategies for Molecular Classification of Asthma Using Bipartite Network Analysis of Cytokine Expression.
- Proteomics improves the prediction of burns mortality: results from regression spline modeling.
- Improved mass defect model for theoretical tryptic peptides.
- Two-step cross-linking for analysis of protein-chromatin interactions.
- How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification.
- RelA Ser 276 Phosphorylation-Coupled Lys 310 Acetylation Controls Transcriptional Elongation Of Inflammatory Cytokines In RSV Infection.
- High throughput siRNA screening of the human kinome identifies novel kinases controlling the canonical NF-kB activation pathway.
- Sources of cell-to-cell variability in canonical NF-{kappa}B signaling pathway inferred from single cell dynamic images.
- Examining Troughs in the Mass Distribution of All Theoretically Possible Tryptic Peptides.
- Quantification of activated NF kappaB/RelA complexes using ssDNA aptamer affinity stable isotope dilution selective reaction monitoring mass spectrometry.
- IKKε modulates RSV-induced NF-κB-dependent gene transcription.
- Role of peroxiredoxin 1 and peroxiredoxin 4 in protection of respiratory syncytial virus-induced cysteinyl oxidation of nuclear cytoskeletal proteins.
- Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines.
- Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent.
- Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.
- An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice.
- Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression.
- Systemic cytokine response profiles associated with respiratory virus-induced acute otitis media.
- Hyperspectral confocal fluorescence imaging: exploring alternative multivariate curve resolution approaches.
- Expression of an IKKgamma splice variant determines IRF3 and canonical NF-kappaB pathway utilization in ssRNA virus infection.
- The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain.
- Expanding role of cyclin dependent kinases in cytokine inducible gene expression.
- Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-induc...
- RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.
- Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines.
- The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
- Involvement of a novel Rac/RhoA guanosine triphosphatase-nuclear factor-kappaB inducing kinase signaling pathway mediating angiotensin II-induced RelA transactivation.
- Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells.
- RhoA mediates angiotensin II-induced phospho-Ser536 nuclear factor kappaB/RelA subunit exchange on the interleukin-6 promoter in VSMCs.
- Ikkepsilon regulates viral-induced interferon regulatory factor-3 activation via a redox-sensitive pathway.
- An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kapp...
- Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex.
- Stochastic regulation in early immune response.
- Identification of an NF-kappaB-dependent gene network in cells infected by mammalian reovirus.
- The NF-kappaB regulatory network.
- Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the i...
- STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.
- Two-step cross-linking method for identification of NF-kappaB gene network by chromatin immunoprecipitation.
- Respiratory syncytial virus influences NF-kappaB-dependent gene expression through a novel pathway involving MAP3K14/NIK expression and nuclear complex formation with ...
- Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.
- Interleukin (IL)-1 beta in tracheal aspirates from premature infants induces airway epithelial cell IL-8 expression via an NF-kappa B dependent pathway.
- Nuclear heat shock response and novel nuclear domain 10 reorganization in respiratory syncytial virus-infected a549 cells identified by high-resolution two-dimensional...
- Liver gene expression associated with diet and lesion development in atherosclerosis-prone mice: induction of components of alternative complement pathway.
- Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis.
- Role of interferon-stimulated responsive element-like element in interleukin-8 promoter in Helicobacter pylori infection.
- Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
- IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection.
- Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases.
- Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta.
- Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells.
- Identification of a nuclear factor kappa B-dependent gene network.
- Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation.
- Respiratory syncytial virus-induced activation of nuclear factor-kappaB in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways.
- Regulation of human airway epithelial cell IL-8 expression by MAP kinases.
- MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression.
- Vascular inflammation and the renin-angiotensin system.
- Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells.
- Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation.
- Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein ...
- Retriever and CompareTable, two informatics tools for data analysis of high-density oligonucleotide arrays.
- The Basic Amino Acid-Rich DNA-Binding Element of the NF-IL6 Transcription Factor Contains Two Functionally Distinct Subdomains.
- Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens.
- Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma.
- RIG-I Enhanced Interferon Independent Apoptosis upon Junin Virus Infection.
- Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.
- Conclusions and future directions.
- Analysis and predictive modeling of asthma phenotypes.
- Measurement of the innate immune response in the airway.
- Systems approaches to modeling chronic mucosal inflammation.
Schools
University of California At San Francisco
BrighamWomens Hospital
Massachusetts General Hospital
Conditions Treated
- Osteoporosis
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Massachusetts General Hospital -
Brigham and Women's Hospital -
University of California San Francisco School of Medicine
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