Associate Professor, Pediatrics, UCSD School of Medicine

Pediatric Hematology & Oncology

Geddis is an expert in the field of Pediatric Hematology & Oncology. She went to medical school at Jefferson Medical College. Geddis is also published. She has 31 publications published. The lastest publication: "Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant system.'

Publications

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• Inherited thrombocytopenias: an approach to diagnosis and management.
• A POTEntial new gene for thrombocytopenia.
• Congenital amegakaryocytic thrombocytopenia.
• Shedding light on endomitosis.
• Megakaryopoiesis.
• Ubiquitination and degradation of the thrombopoietin receptor c-Mpl.
• Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.
• PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1).
• Immunology. The root of Platelet production.
• Diagnosis of immune thrombocytopenic purpura in children.
• Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression.
• Inherited thrombocytopenia: Congenital amegakaryocytic thrombocytopenia and thrombocytopenia with absent radii.
• Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation.
• Megakaryocytes express functional Aurora-B kinase in endomitosis.
• Inherited thrombocytopenias: toward a molecular understanding of Disorders of platelet production.
• Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency.
• Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for Cellular proliferation.
• Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing Cell lines as well as in primary megak...
• Expression of human COL1A1 gene in stably transfected HT1080 cells: the production of a thermostable homotrimer of type I collagen in a recombinant System.
• High levels of expression of a minigene version of the human pro alpha 1 (I) collagen gene in stably transfected mouse fibroblasts. Effects of deleting putative regula...
• Deletion of JAM-C, a candidate gene for heart Defects in Jacobsen syndrome, results in a normal cardiac phenotype in mice.
• Temozolomide and radiation for aggressive pediatric central Nervous system malignancies.
• The Mpl receptor expressed on endothelial Cells does not contribute significantly to the regulation of circulating thrombopoietin levels.
• Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent Cell lines and p...
• The molecular basis of congenital thrombocytopenias: insights into megakaryopoiesis.
• Compound heterozygous c-Mpl mutations in a child with congenital amegakaryocytic thrombocytopenia: functional characterization and a review of the literature.
• Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic Cells through a beta-catenin-independent pathway.
• Thrombopoietin: a pan-hematopoietic cytokine.
• The regulation of proPlatelet production.
• F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic...

Schools

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• Thomas Jefferson University

• University Of Wa School Of Med

Conditions Treated

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• Acute Leukemia
• Adrenal Gland Cancer
• Anemia
• Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
• View All

Doctors Specialties

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• Pediatric Hematology
• Oncology

Accepted Insurances

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Education

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• University of Washington
• University of Pittsburgh Medical Center
• Jefferson Medical College

Hospital

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• Rady Children's Hospital - San Diego

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