Professor, Medicine, UCLA School of Medicine
Allergy & Immunology
Dr. Andre E. Nel, MD
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Doctor Andre E. Nel, MD works in the field of Allergy & Immunology. He went to Medical University of South Carolina. He received awards:"CMS Meaningful Use Stage 1 Certification" and "Elected Member". Doctor Andre E. Nel, MD has written publications. He has 98 publications published with PubMed. The lastest paper is: 'Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line.'
Publications
- Implications of the Differential Toxicological Effects of III-V Ionic and Particulate Materials for Hazard Assessment of Semiconductor Slurries.
- Organ-Specific and Size-Dependent Ag Nanoparticle Toxicity in Gills and Intestines of Adult Zebrafish.
- Use of a pro-fibrogenic mechanism-based predictive toxicological approach for tiered testing and decision analysis of carbonaceous nanomaterials.
- Nanomaterial Categorization for Assessing Risk Potential To Facilitate Regulatory Decision-Making.
- Understanding the transformation, speciation, and hazard potential of copper particles in a model septic tank system using zebrafish to monitor the effluent.
- Toxicity of Metal Oxide Nanoparticles in Escherichia coli Correlates with Conduction Band and Hydration Energies.
- NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes.
- Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1β Producing Inflammasome.
- Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract.
- Relating Nanoparticle Properties to Biological Outcomes in Exposure Escalation Experiments.
- Surface interactions with compartmentalized cellular phosphates explain rare Earth oxide nanoparticle hazard and provide opportunities for safer design.
- Interview: Nanomedicine and the fight against HIV/AIDS.
- Engineering an Effective Immune Adjuvant by Designed Control of Shape and Crystallinity of Aluminum Oxyhydroxide Nanoparticles.
- Two-wave nanotherapy to target the stroma and optimize gemcitabine delivery to a human pancreatic cancer model in mice.
- Association rule mining of cellular responses induced by metal and metal oxide nanoparticles.
- Sulforaphane-rich broccoli sprout extract attenuates nasal Allergic response to diesel exhaust particles.
- Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential.
- A Multi-Stakeholder Perspective on the Use of Alternative Test Strategies for Nanomaterial Safety Assessment.
- Implementation of alternative test strategies for the safety assessment of engineered nanomaterials.
- Real-time electrical detection of nitric oxide in biological systems with sub-nanomolar sensitivity.
- Hierarchical Rank Aggregation with Applications to Nanotoxicology.
- Zebrafish: An In Vivo Model for Nano EHS Studies.
- Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1.
- Metal Oxides: Zebrafish High-Throughput Screening to Study the Impact of Dissolvable Metal Oxide Nanoparticles on the Hatching Enzyme, ZHE1 (Small 9-10/2013).
- Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano Go Consortium.
- Interlaboratory Evaluation of Rodent Pulmonary Responses to Engineered Nanomaterials: The NIEHS Nano Go Consortium.
- Development of structure-activity relationship for metal oxide nanoparticles.
- Nrf2 Deficiency in Dendritic Cells Enhances the Adjuvant Effect of Ambient Ultrafine Particles on Allergic Sensitization.
- Climate Change and Our Environment: The Effect on Respiratory and Allergic Disease.
- Surface charge and cellular processing of covalently functionalized multiwall carbon nanotubes determine pulmonary toxicity.
- Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo.
- Implementation of a Multidisciplinary Approach to Solve Complex Nano EHS Problems by the UC Center for the Environmental Implications of Nanotechnology.
- Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic.
- Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High-Throughput Screening.
- Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation.
- Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials.
- The Dispersal State of Multi-walled Carbon Nanotubes Elicits Pro-Fibrogenic Cellular Responses that Correlate with Fibrogenesis Biomarkers and Fibrosis in the Murine L...
- High Content Screening in Zebrafish Speeds up Hazard Ranking of Transition Metal Oxide Nanoparticles.
- Role of Fe doping in tuning the band gap of TiO2 for the photo-oxidation-induced cytotoxicity paradigm.
- Feasibility of biomarker studies for engineered nanoparticles: what can be learned from air pollution research.
- Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism.
- Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Na...
- Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells.
- Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.
- Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.
- Nanomaterials in the environment: from materials to high-throughput screening to organisms.
- Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells.
- Dispersion and stability optimization of TiO2 nanoparticles in cell culture media.
- Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.
- Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares.
- Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line.
- Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping.
- Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs.
- The University of California Center for the Environmental Implications of Nanotechnology.
- Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition.
- A predictive toxicological paradigm for the safety assessment of nanomaterials.
- The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential.
- Potential health impact of nanoparticles.
- Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid.
- Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery.
- Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
- Innate immune responses during respiratory tract infection with a bacterial pathogen induce Allergic airway sensitization.
- The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles.
- Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.
- Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
- T-cell effector pathways in Allergic diseases: transcriptional mechanisms and therapeutic targets.
- Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress.
- Importance of oxidative stress in the pathogenesis and treatment of asthma.
- Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.
- Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence.
- Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.
- Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease.
- Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.
- Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm.
- Tracheobronchial particle dose considerations for in vitro toxicology studies.
- How exposure to environmental tobacco smoke, outdoor air pollutants, and increased Pollen burdens influences the incidence of asthma.
- Role of the Nrf2-mediated signaling pathway as a negative regulator of inflammation: implications for the impact of particulate pollutants on asthma.
- The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice.
- Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects...
- Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line.
- Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects.
- Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages.
- T-cell activation through the antigen receptor. Part 2: role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy.
- T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse.
- Protein kinase D is a downstream target of protein kinase Ctheta.
- Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.
- New Palaeogene horntail wasps (Hymenoptera, Siricidae) and a discussion of their fossil record.
- A new genus and species of ibis fly in the Lowermost Eocene amber of Oise (France) (Diptera: Athericidae).
- Nanoinformatics workshop report: Current resources, community needs, and the proposal of a collaborative framework for data sharing and information integration.
- Rapid purification of protein kinase C from rat brain. A novel method employing protamine-agarose affinity column chromatography.
- Structural studies of T lymphocyte Fc receptors. Association of Gc protein with IgG binding to Fc gamma.
- Involvement of Stat3 in interleukin-6-induced IgM production in a human B-cell line.
- Developmental regulation of pp44/46, tyrosine-phosphorylated proteins associated with tyrosine/serine kinase activity in Trypanosoma brucei.
- C-kinase activity in normal B cells treated with Staphylococcus aureus, Cowan strain I, and phorbol ester: response differences in a patient with prolymphocytic leukae...
- Promotion of DNA strand breaks in cocultured mononuclear leukocytes by protein kinase C-dependent prooxidative interactions of benoxaprofen, human polymorphonuclear le...
- Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes.
- Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Shows Improved Efficacy and Safety over Liposomes for Pancreatic Cancer.
Schools
UNIVERSITY OF STELLENBOSCH FACULTY OF MEDICINE
Tygerberg Hospital
University Sc
Conditions Treated
- Allergic Rhinitis
- Bronchitis
- Chronic Sinusitis
- Hypogammaglobulinemia
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Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
Education
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Medical University of South Carolina -
Stellenbosch University Faculty of Medicine
Hospital
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Ronald Reagan UCLA Medical Center
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