Professor of Pathology, Professor of Oncology, Professor of Urology, Johns Hopkins University School of Medicine; Associate Director of Cancer Research Pathology, SKCCC, Director, Tissue Microarray Core Facility
Pathology
Dr. Angelo M. Demarzo, MD
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Dr. Angelo M. Demarzo works in the field of Pathology. Angelo Demarzo has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Heterogeneity of PTEN and ERG expression in prostate cancer on core needle biopsies: implications for cancer risk stratification and biomarker sampling.' He accepts Medicare payments and is listed with Medicare.gov.
Publications
- Overlap of CD44 expression between prostatic small cell carcinoma and acinar adenocarcinoma.
- Diagnostic challenges of clonal heterogeneity in prostate cancer.
- Heterogeneity of PTEN and ERG expression in prostate cancer on core needle biopsies: implications for cancer risk stratification and biomarker sampling.
- LEF1 Targeting EMT in Prostate Cancer Invasion Is Regulated by miR-34a.
- Utility of PTEN and ERG Immunostaining for Distinguishing High-grade PIN From Intraductal Carcinoma of the Prostate on Needle Biopsy.
- A Peripheral Circulating TH1 Cytokine Profile Is Inversely Associated with Prostate Cancer Risk in CLUE II.
- Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial.
- Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.
- Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy.
- PTEN loss is associated with upgrading of prostate cancer from biopsy to radical prostatectomy.
- The role of inflammation in prostate cancer.
- High prevalence of screen-detected prostate cancer in West Africans: implications for racial disparity of prostate cancer.
- t(6;11) Renal Cell Carcinoma (RCC): Expanded Immunohistochemical Profile Emphasizing Novel RCC Markers and Report of 10 New Genetically Confirmed Cases.
- Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers.
- Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma.
- USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression.
- MSMB variation and prostate cancer risk: Clues towards a possible fungal etiology.
- Telomere length as a risk factor for hereditary prostate cancer.
- Small renal mass biopsy - how, what and when: report from an international consensus panel.
- Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network.
- Combined Treatment Effects of Radiation and Immunotherapy: Studies in an Autochthonous Prostate Cancer Model.
- A subset of malignant phyllodes tumors harbors alterations in the Rb/p16 pathway.
- Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease.
- Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia.
- Assessing the order of critical alterations in prostate cancer development and progression by IHC: further evidence that PTEN loss occurs subsequent to ERG gene fusion.
- A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes.
- A broad survey of cathepsin k immunoreactivity in human neoplasms.
- Base pair resolution analysis of TMPRSS2-ERG rearrangements in prostate cancer.
- Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy.
- Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors.
- XMRV and prostate cancer-a 'final' perspective.
- PI3K/mTOR signaling regulates prostatic branching morphogenesis.
- Androgen receptor expression is usually maintained in initial surgically resected breast cancer metastases but is often lost in end-stage metastases found at autopsy.
- MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors.
- NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
- Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture.
- Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms.
- Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes.
- PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients.
- Immunoexpression Status and Prognostic Value of mTOR and Hypoxia-Induced Pathway Members in Primary and Metastatic Clear Cell Renal Cell Carcinomas.
- Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.
- Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas.
- Immunohistochemistry for ERG Expression as a Surrogate for TMPRSS2-ERG Fusion Detection in Prostatic Adenocarcinomas.
- Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic se...
- Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene.
- High prevalence of polyclonal hypergamma-globulinemia in adult males in Ghana, Africa.
- Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
- ERG gene rearrangements are common in prostatic small cell carcinomas.
- Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.
- Humanizing ??-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose.
- XMRV: a new virus in prostate cancer?
- Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy.
- DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue.
- Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers.
- 8q24 allelic imbalance and MYC gene copy number in primary prostate cancer.
- NKX3.1 as a marker of prostatic origin in metastatic tumors.
- Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
- MYC and Prostate Cancer.
- A pharmacodynamic study of rapamycin in men with intermediate- to high-risk localized prostate cancer.
- Prostate-specific antigen (PSA) is activated by KLK2 in prostate cancer ex vivo models and in prostate-targeted PSA/KLK2 double transgenic mice.
- The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells.
- Loss of Nkx3.1 expression in bacterial prostatitis: a potential link between inflammation and neoplasia.
- Human papillomavirus types 16, 18, and 31 serostatus and prostate cancer risk in the Prostate Cancer Prevention Trial.
- MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.
- Cell-autonomous intracellular androgen receptor signaling drives the growth of human prostate cancer initiating cells.
- TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma.
- Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+.
- Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers.
- Dual-label centromere and telomere FISH identifies human, rat, and mouse cell contribution to Multispecies recombinant urogenital sinus xenografts.
- Epigenetic alterations in human prostate cancers.
- Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
- Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II.
- Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model.
- Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate.
- Trichomonosis and subsequent risk of prostate cancer in the Prostate Cancer Prevention Trial.
- Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells.
- Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer.
- TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas.
- Genome-wide expression analysis of recently processed formalin-fixed paraffin embedded human prostate tissues.
- Effect of DNA methylation on identification of aggressive prostate cancer.
- The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells.
- Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors.
- DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity.
- Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets.
- GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus.
- Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis.
- Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.
- Cytokine profiling of prostatic fluid from cancerous prostate glands identifies cytokines associated with extent of tumor and inflammation.
- Increased spermine oxidase expression in human prostate cancer and prostatic intraepithelial neoplasia tissues.
- Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases.
- A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microo...
- Human Proteinpedia enables sharing of human protein data.
- Tamoxifen-stimulated growth of breast cancer due to p21 loss.
- Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion.
- Viral infections and lower urinary tract symptoms in the third national health and nutrition examination survey.
- Inflammation, atrophy, and prostate carcinogenesis.
- Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum.
- Plasma antibodies against Chlamydia trachomatis, human papillomavirus, and human herpesvirus type 8 in relation to prostate cancer: a prospective study.
- Immunohistochemical differentiation of high-grade prostate carcinoma from urothelial carcinoma.
- Workshop on imaging science development for cancer prevention and preemption.
Doctors Specialties
- Anatomic Pathology
- Pathology
Accepted Insurances
Hospital
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Johns Hopkins Bayview Medical Center -
Johns Hopkins Hospital
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Medicare Facts
| National Provider Identifier [NPI] | 1770510380 |
| Last Name Of The Provider | DEMARZO |
| First Name Of The Provider | ANGELO |
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