Professor of Pathology, University Pittsburgh
Pathology
Dr. Anthony J. Demetris, MD
Anthony J. Demetris works in the field of Pathology. He researched medicine at University of Pittsburgh School of Medicine. He received awards:"America's Top Doctors" and "Pittsburgh Magazine". Anthony Demetris is a published MD as well. He has 98 publications published. The latest was: Prevention and treatment of liver allograft antibody-mediated rejection and the role of the 'two-hit hypothesis'. Anthony Demetris is registered with Medicare.
Publications
- Prevention and treatment of liver allograft antibody-mediated rejection and the role of the 'two-hit hypothesis'.
- Breast Tumor Kinase/Protein Tyrosine Kinase 6 (Brk/PTK6) Activity in Normal and Neoplastic Biliary Epithelia.
- Liver-Specific Deletion of Augmenter of Liver Regeneration Accelerates Development of Steatohepatitis and Hepatocellular Carcinoma in Mice.
- A validated model for predicting outcome after liver transplantation: implications on transplanting the extremely sick.
- Small Proline Rich Protein 2a in Benign and Malignant Liver Disease.
- Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury.
- Preexisting epithelial diversity in normal human livers: a tissue-tethered cytometric analysis in portal/periportal epithelial cells.
- Tissue biopsy monitoring of operational tolerance in liver allograft recipients.
- Allograft outcomes in outbred mice.
- Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression.
- Gut Bacteria Drive Kupffer Cell Expansion via MAMP-Mediated ICAM-1 Induction on Sinusoidal Endothelium and Influence Preservation-Reperfusion Injury after Orthotopic L...
- Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants.
- Cholangiopathy: genetics, mechanism, and pathology.
- Innate immunity alone is not sufficient for chronic rejection but predisposes healed allografts to T cell-mediated pathology.
- Acute and chronic rejection in upper extremity transplantation: what have we learned?
- The Role of the A2a Receptor Agonist, Regadenoson, in Modulating Hepatic Artery Flow in the Porcine Small-for-Size Liver Graft.
- Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improves GVL and immune reconstitution.
- A repertoire-independent and cell intrinsic defect in murine GVHD induction by effector memory T cells.
- Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4⺠effector memory T cells.
- Memory T Cells Migrate to and Reject Vascularized Cardiac Allografts Independent of the Chemokine Receptor CXCR3.
- Hepatic B7-H1 expression is essential to control cold ischemia/reperfusion injury after mouse liver transplantation.
- Langerhans cells are not required for graft-versus-host disease.
- Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
- Heterotopic breast epithelial inclusion of the heart: report of a case.
- Recipient B cells are not required for graft-versus-host disease induction.
- Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition ...
- NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.
- Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans.
- Histologic graft assessment after clinical islet transplantation.
- Evolution of hepatitis C virus in liver allografts.
- Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center.
- Allospecific CD154+ T cells associate with rejection risk after pediatric liver transplantation.
- Expression of specific hepatocyte and cholangiocyte transcription factors in human liver disease and embryonic development.
- Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function tests.
- Plasma cell hepatitis in liver allografts: Variant of rejection or autoimmune hepatitis?
- Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells.
- Posttransplant adenoviral enteropathy in patients with small bowel transplantation.
- Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation.
- Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 poly...
- Memory T cells in GVHD and GVL.
- Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6/signal transducer and activator of transcription ...
- Protection from acute cellular injury using Sleeping Beauty mediated telomerase gene transfer.
- Progressive fibrosis in nonalcoholic steatohepatitis: association with altered regeneration and a ductular reaction.
- Growth factor-induced mobilization of dendritic cells in kidney and liver of rhesus macaques: implications for transplantation.
- Wnt'er in liver: expression of Wnt and frizzled genes in mouse.
- CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allografts.
- Distinguishing between recurrent primary sclerosing cholangitis and chronic rejection.
- Liver transplantation in precirrhotic biliary tract disease: Portal hypertension is frequently associated with nodular regenerative hyperplasia and obliterative portal...
- Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas.
- Simultaneous bone marrow and intestine transplantation promotes marrow-derived hematopoietic stem cell engraftment and chimerism.
- Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome.
- Histopathologic characteristics of human intestine allograft acute rejection in patients pretreated with thymoglobulin or alemtuzumab.
- A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells.
- MELD and prediction of post-liver transplantation survival.
- Caroli's disease and orthotopic liver transplantation.
- The difficulty of eliminating donor leukocyte microchimerism in rat recipients bearing established organ allografts.
- 3D-confocal structural analysis of bone marrow-derived renal tubular cells during renal ischemia/reperfusion injury.
- Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles.
- Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection.
- Early HCV-associated stellate cell activation in aggressive recurrent HCV: what can liver allografts teach about HCV pathogenesis?
- An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis.
- Liver transplantation for severe intrahepatic noncirrhotic portal hypertension.
- Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath.
- Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression.
- Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation.
- Regulation and function of trefoil factor family 3 expression in the biliary tree.
- A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodies.
- Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus.
- Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling.
- Webcasting pathology department conferences in a geographically distributed medical center.
- De novo malignancies after intestinal and multivisceral transplantation.
- Lessons of organ-induced tolerance learned from historical clinical experience.
- The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells.
- Acute cholestatic hepatitis associated with long-term use of rofecoxib.
- Progression of liver fibrosis in patients with chronic hepatitis C after orthotopic liver transplantation.
- Kidney transplantation under a tolerogenic regimen of recipient pretreatment and low-dose postoperative immunosuppression with subsequent weaning.
- Four-color flow cytometric analysis of peripheral blood donor cell chimerism.
- Suprahepatic Budd-Chiari syndrome treated with thrombectomy and cavoplasty.
- Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival.
- Chimerism and tolerance in rat recipients of intestinal allografts from ALS-treated donors with and without adjunct naïve-donor-strain bone-marrow cells.
- Microdissection-based allelotyping discriminates de novo tumor from intrahepatic spread in hepatocellular carcinoma.
- Production of alpha 1,3-galactosyltransferase-deficient pigs.
- Azithromycin-induced intrahepatic cholestasis.
- ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions.
- Early passenger leukocyte migration and acute immune reactions in the rat recipient spleen during liver engraftment: with particular emphasis on donor major histocompa...
- Impact of anti-hepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosis.
- Five cases of fulminant hepatitis due to herpes simplex virus in adults.
- A prospective randomized trial of mycophenolate mofetil in liver transplant recipients with hepatitis C.
- Correction of congenital hyperbilirubinemia in homozygous Gunn rats by xenotransplantation of hamster livers.
- Tacrolimus (FK506)-Associated Renal Pathology.
- Prevention of Transplant Rejection: Can Tolerance be Achieved with Immunosuppressive Treatment?
- Kidney/Bone Marrow Transplantation.
- Clinical xenotransplantation.
- The Role of Cell Migration and Chimerism in Organ Transplant Acceptance and Tolerance Induction.
- Reversal of Graft-Versus-Host Disease with Infusion of Stored Autologous Bone Marrow Cells Following Combined Liver-Bone Marrow Allotransplantation in Man.
- HLA matching and the point system.
- Evidence for hyperacute rejection of human liver grafts: The case of the canary kidneys.
Schools
University of Pittsburgh Main Campus
Doctors Specialties
- Pathology
Accepted Insurances
- CoreSource
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- America's Top Doctors
- Pittsburgh Magazine
Education
-
University of Pittsburgh Medical Center -
University of Pittsburgh School of Medicine
Hospital
-
UPMC Passavant -
UPMC Presbyterian Shadyside
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1033181524 |
| Last Name Of The Provider | DEMETRIS |
| First Name Of The Provider | ANTHONY |
| View All |
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