Assistant Professor of Medicine and Pathology/Immunology, Washington University School of Medicine

Cardiology

Dr. Babak Razani practices Cardiology. He studied medicine at Albert Einstein College of Medicine of Yeshiva University. Babak Razani is a published doctor and has 40 publications published. The lastest was: 'Can the DNA damage response be harnessed to modulate atherosclerotic plaque phenotype?' He accepts Medicare.

Publications

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• Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells.
• Can the DNA damage response be harnessed to modulate atherosclerotic plaque phenotype?
• Fatty acid synthase modulates homeostatic responses to Myocardial stress.
• p53 is required for chloroquine-induced atheroprotection but not insulin sensitization.
• Induction of lysosomal biogenesis in atherosclerotic macrophages can rescue lipid-induced lysosomal dysfunction and downstream sequelae.
• Getting away from glucose: stop sugarcoating diabetes.
• Self-eating in the plaque: what macrophage autophagy reveals about atherosclerosis.
• Insulin resistance and atherosclerosis.
• Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
• Interleukins and atherosclerosis: a dysfunctional family grows.
• Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.
• Emerging themes in lipid rafts and caveolae.
• Caveolin-deficient mice: insights into caveolar function human Disease.
• Caveolae and caveolin-3 in muscular dystrophy.
• Caveolins and caveolae: molecular and functional relationships.
• Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A.
• Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
• Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy.
• Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins.
• Caveolin-1, a putative tumour suppressor gene.
• Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo.
• Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A.
• Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism.
• Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor.
• Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HP...
• Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppr...
• p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascad...
• Angiogenesis activators and inhibitors differentially regulate caveolin-1 expression and caveolae formation in vascular endothelial cells. Angiogenesis inhibitors bloc...
• Role of caveolin-1 in the modulation of lipolysis and lipid droplet formation.
• Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hy...
• Caveolin-1 null (-/-) mice show dramatic reductions in life span.
• Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue.
• Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.
• Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
• Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice sh...
• Caveolae: from cell biology to animal physiology.
• Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis.
• Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.
• Caveolin-2-deficient mice show evidence of severe Pulmonary dysfunction without disruption of caveolae.

Schools

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• Albert Einstein College of Medicine of Yeshiva University

• Washington University School Of Med Barnes Jewish Hospital

• Barnes Jewish Hospital

Procedures Preformed

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• Cardiac Catheterization (incl. Coronary Angiography)
• Cardiac Imaging
• Cardiac Myocardial Perfusion Imaging
• Cardioverter-Defibrillator or Pacemaker Insertion, Removal or Repair
• View All

Conditions Treated

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• Angina and Acute Coronary Syndrome
• Aortic Aneurysm
• Aortic Valve Disease
• Arrhythmias (incl. Atrial Fibrillation)
• View All

Doctors Specialties

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• Cardiology

Accepted Insurances

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Education

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• Washington University
• Washington University - Barnes-Jewish Hospital
• Albert Einstein College of Medicine of Yeshiva University

Hospital

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• Barnes-Jewish Hospital

Helpful Reviews

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Give Anonymous Review

Medicare Facts

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National Provider Identifier [NPI]	1184756447
Last Name Of The Provider	RAZANI
First Name Of The Provider	BABAK
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