Professor, Medicine, University of Washington School of Medicine
Hematology
Dr. Barbara A. Konkle, MD
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Barbara Konkle works in the field of Hematology. She went to Vanderbilt University School of Medicine. Doctor Barbara A. Konkle, MD is a published physician. She has 95 publications published. The most current publication "To GpIb or not to GpIb." She accepts Medicare.
Publications
- Von Willebrand factor for menorrhagia: a survey and literature review.
- Characteristics Associated With Annual Bleeding Frequency Among Hemophilia Patients In The United States.
- High density lipoprotein modulates Thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion.
- Antithrombin concentrates use in children on extracorporeal membrane oxygenation: a retrospective cohort study.
- Brain-derived microparticles induce systemic coagulation in a murine model of traumatic Brain injury.
- What is the effect of rivaroxaban on routine Coagulation tests?
- Postpartum von Willebrand factor levels in women with and without von Willebrand Disease and implications for prophylaxis.
- Rituximab for treatment of inhibitors in haemophilia A. A Phase II Study.
- N-Acetylcysteine: an old drug, a new insight, a potentially effective treatment for thrombotic thrombocytopenic purpura.
- Atherosclerosis is not a risk factor for anti-Platelet factor 4/heparin antibody formation after cardiopulmonary bypass surgery.
- Comparative field study evaluating the activity of recombinant factor VIII Fc fusion protein in plasma samples at clinical haemostasis laboratories.
- Normal cleavage of von Willebrand factor by ADAMTS-13 in the absence of factor VIII in patients with severe Hemophilia A.
- Similarity in joint function limitation in Type 3 von Willebrand's Disease and moderate haemophilia A.
- Factor VIII mutation and desmopressin-responsiveness in 62 patients with mild haemophilia A.
- Novel diagnostic assays for heparin-induced thrombocytopenia.
- Monitoring target specific anticoagulants.
- Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors.
- An algorithmic approach to peripheral artery disease in Hemophilia: extrapolation of management principles from noncoagulopathic patients.
- Clinical challenges within the aging Hemophilia population.
- Dose of prophylactic Platelet transfusions and prevention of hemorrhage.
- Von Willebrand disease and other bleeding Disorders in women: consensus on diagnosis and management from an international expert panel.
- Defining effective therapies in transfusion medicine and hemostasis: new opportunities with the TMH Network.
- Fresh frozen plasma prepared with amotosalen HCl (S-59) photochemical pathogen inactivation: transfusion of patients with congenital Coagulation factor deficiencies.
- Percutaneous interventions in the coagulopathic patient.
- Total knee arthroplasty using recombinant factor VII in Hemophilia-A patients with inhibitors. A report of three cases.
- Bleeding and Hypercoagulable problems in women.
- Use of recombinant human antithrombin in patients with congenital antithrombin deficiency undergoing surgical procedures.
- Thrombotic Disorders: diagnosis and treatment.
- Role of splenectomy in patients with refractory or relapsed thrombotic thrombocytopenic purpura.
- Complex Changes in von Willebrand Factor-Associated Parameters Are Acquired during Uncomplicated Pregnancy.
- Correlates of spontaneous clearance of hepatitis C virus among people with Hemophilia.
- Chronic hepatitis B and other correlates of spontaneous clearance of hepatitis C virus among HIV-infected people with Hemophilia.
- Evaluation of thromboelastography for monitoring recombinant activated factor VII ex vivo in haemophilia A and B patients with inhibitors: a multicentre trial.
- Phase I study of the novel taxane CT-2103 in patients with advanced solid tumors.
- Counseling of women with thrombophilia.
- Laboratory evaluation of von Willebrand Disease.
- Complementary DNA cloning of the alternatively expressed endothelial Cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22.
- Plasminogen activator inhibitor-1 mRNA is expressed in Platelets and megakaryocytes and the megakaryoblastic cell line CHRF-288.
- Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibbeta promoter resulting in the Bernard-Soulier Syndrome.
- Arterial shear stress stimulates surface expression of the endothelial glycoprotein Ib complex.
- Thrombotic thrombocytopenic purpura: a paradigm shift?
- Nonsense mutation in exon V of the factor XI gene does not abolish Platelet factor XI expression.
- Characterization of high-risk HIV-1 seronegative Hemophiliacs.
- Genetic predisposition to bleeding during oral anticoagulant therapy: evidence for common founder mutations (FIXVal-10 and FIXThr-10) and an independent CpG hotspot mu...
- Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery.
- Thrombophilia: what's a practitioner to do?
- Approaches to successful total knee arthroplasty in haemophilia A patients with inhibitors.
- Plasminogen activator inhibitor-1 messenger RNA expression is induced in rat hepatocytes in vivo by dexamethasone.
- Tumor necrosis factor-alpha modulation of glycoprotein Ib alpha expression in human endothelial and erythroleukemia Cells.
- Heparin-binding growth factor-1 modulation of plasminogen activator inhibitor-1 expression. Interaction with cAMP and protein kinase C-mediated pathways.
- Cytokine-enhanced expression of glycoprotein Ib alpha in human endothelium.
- Molecular basis of human von Willebrand disease: analysis of Platelet von Willebrand factor mRNA.
- RsaI RFLP in the human von Willebrand factor gene.
- SacI RFLP in the human von Willebrand factor gene.
- The addition of endothelial cell growth factor and heparin to human umbilical Vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression.
- Plasminogen activator inhibitor-1 expression by Brain microvessel endothelial cells is inhibited by elevated glucose.
- Microvascular Disease in diabetes mellitus.
- Prevalence of heparin-associated antibodies without Thrombosis in patients undergoing cardiopulmonary bypass surgery.
- Human endothelial Cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex.
- Parvovirus B19 quiescence during the course of human immunodeficiency virus infection in persons with Hemophilia.
- Endothelial cells in physiology and in the pathophysiology of vascular Disorders.
- Tissue-specific expression of functional Platelet factor XI is independent of plasma factor XI expression.
- Activated protein C resistance, factor V Leiden, and central retinal Vein occlusion in young adults.
- To GpIb or not to GpIb.
- Platelet von Willebrand factor determination does not improve the diagnosis of patients with suspected Type 1 von Willebrand disease.
- Interlaboratory agreement in the monitoring of unfractionated heparin using the anti-factor Xa-correlated activated partial thromboplastin time.
- Bleeding symptoms and laboratory correlation in patients with severe von Willebrand Disease.
- Randomized, prospective clinical trial of recombinant factor VIIa for secondary prophylaxis in Hemophilia patients with inhibitors.
- Secondary prophylaxis with recombinant activated factor VII improves health-related quality of life of haemophilia patients with inhibitors.
- Congenital factor VII deficiency: therapy with recombinant activated factor VII -- a critical appraisal.
- Identification of a patient with Bernard-Soulier Syndrome and a deletion in the DiGeorge/velo-cardio-facial chromosomal region in 22q11.2.
- P-selectin mRNA is expressed at a later phase of megakaryocyte maturation than mRNAs for von Willebrand factor and glycoprotein Ib-alpha.
- Preanalytical conditions that affect coagulation testing, including hormonal status and therapy.
- von Willebrand Disease: treatment with or without factor VIII?
- How we treat: haematuria in adults with haemophilia.
- The longitudinal effect of body adiposity on joint mobility in young males with Haemophilia A.
- When should prophylaxis therapy in inhibitor patients be considered?
- Role of exercise and physical activity on haemophilic arthropathy, fall prevention and osteoporosis.
- Surveillance of female patients with inherited bleeding Disorders in United States Haemophilia Treatment Centres.
- False normal von Willebrand factor activity by monoclonal antibody-based ELISA in a patient with type 2A(IID) von Willebrand Disease.
- The bernard-soulier Syndrome.
- The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion.
- A single-center experience of preemptive antiCoagulation for patients with risk factors for allograft thrombosis in renal transplantation.
- Platelet and monocyte antigenic complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT).
- Emerging clinical concerns in the ageing haemophilia patient.
- Successful transduction of liver in Hemophilia by AAV-Factor IX and limitations imposed by the host immune response.
- An unusual case of toe ulceration.
- Safety and efficacy of gene transfer for Leber's congenital amaurosis.
- Assessment of within-group variation in CYP1A mRNA inducibility in environmentally exposed and chemically treated Atlantic tomcod.
- Mean platelet volume as a predictor of cardiovascular risk: a Systematic review and meta-analysis.
- Phenotypic expressions of CCR5-delta32/delta32 homozygosity.
- Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in Cancer-prone Atlantic tomcod.
- Prevention and treatment of Venous thromboembolism in pregnancy in patients with hereditary antithrombin deficiency.
- Characterization of CYP1A1 gene regulatory elements in Cancer-prone Atlantic tomcod.
Schools
Vanderbilt University
Rush Presby St Lukes Hosps
University Of Michigan
Conditions Treated
- Anemia
- Antiphospholipid Syndrome (APS)
- Bladder Cancer
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
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Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Education
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Rush University Medical Center -
Vanderbilt University School of Medicine
Hospital
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UW Medicine/Harborview Medical Center -
University of Washington Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1972545796 |
| Last Name Of The Provider | KONKLE |
| First Name Of The Provider | BARBARA |
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