Professor, Pediatrics, Texas AandM University College of Medicine
Pediatrics
Dr. Brett P. Giroir, MD
Brett Giroir is an expert in the field of Pediatrics. He studied medicine at University of Texas Southwestern Medical School. Dr. Brett P. Giroir has written publications. He has 68 publications published with PubMed. The lastest publication is: 'Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha.'
Publications
- ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis.
- The Pediatric Multiple Organ Dysfunction Score (P-MODS): development and validation of an objective scale to measure the severity of multiple organ dysfunction in crit...
- Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.
- Macrophage migration inhibitory factor mediates late cardiac dysfunction after burn injury.
- Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants.
- Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis.
- Macrophage migration inhibitory factor is a cardiac-derived myocardial depressant factor.
- IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction.
- Pediatric critical care medicine: planning for our research future.
- Recombinant human activated protein C for the treatment of severe sepsis: is there a role in pediatrics?
- Usefulness of external counterpulsation early postoperatively after the Fontan procedure in children.
- Burn plasma mediates cardiac myocyte apoptosis via endotoxin.
- Myocardial inflammatory activation in children with congenital heart disease.
- Improving the outcome of septic shock in children.
- International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
- A pilot pharmacokinetic study of tricyclic antidepressant ovine Fab for TCA poisoning in children.
- Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.
- The authors reply: academic and industry partnerships.
- Molecular and pharmacological approaches to inhibiting nitric oxide after burn trauma.
- I kappa B overexpression in cardiomyocytes prevents NF-kappa B translocation and provides cardioprotection in trauma.
- Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-alpha transgenic mice.
- Overexpression of cardiac I-kappaBalpha prevents endotoxin-induced myocardial dysfunction.
- Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Men...
- Pancreatitis, cytokines, and SIRS: déjàvu all over again?
- Bactericidal/permeability-increasing protein--lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe...
- Differential regulation of myocardial NF kappa B following acute or chronic TNF-alpha exposure.
- Aspiration pneumonia-induced sepsis increases cardiac dysfunction after burn trauma.
- Molecular biology of septic shock.
- Myocardial depression versus myocardial destruction: integrating the multiple mechanisms of myocardial dysfunction during sepsis.
- Preoperative and postoperative endotoxemia in children with congenital heart disease.
- Increased cardiomyocyte intracellular calcium during endotoxin-induced cardiac dysfunction in guinea pigs.
- Inhibition of tumor necrosis factor prevents myocardial dysfunction during burn shock.
- Sequence analysis of the tumor necrosis factor gene in pediatric patients with autoimmunity.
- Regulation of cytokine gene expression: tumor necrosis factor, interleukin-1, and the emerging biology of cytokine receptors.
- Cytokine-induced expression of nitric oxide synthase in C2C12 skeletal muscle myocytes.
- H-2-determined kinetic differences for the induction of nucleoside-specific suppression.
- Nucleoside-specific suppression in MRL/MP +/+ mice.
- Cell lines derived from avian lymphomas exhibit two distinct phenotypes.
- Bronchocentric granulomatosis in a nonasthmatic adolescent.
- Effect of amrinone on tumor necrosis factor production in endotoxic shock.
- Constitutive synthesis of tumor necrosis factor in the thymus.
- The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
- The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors.
- Complementary DNA (cDNA) sequence of baboon tumor necrosis factor alpha.
- New therapies for severe meningococcal disease.
- Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal/permeability-increasing protein in children with severe meningococcal sepsis.
- Expression of the inducible nitric oxide synthase gene in diaphragm and skeletal muscle.
- Pathophysiology, treatment and outcome of meningococcemia: a review and recent experience.
- Mediators of septic shock: new approaches for interrupting the endogenous inflammatory cascade.
- Effects of transforming growth factor-beta 1 on nitric oxide synthesis by C2C12 skeletal myocytes.
- Obesity, macrophage migration inhibitory factor, and weight loss.
- Bactericidal/permeability-increasing protein: clinical development and potential pediatric applications.
- Human coronary endothelial cell activation by endotoxin is characterized by NF-kappa B activation and TNF-alpha synthesis.
- Development of an acute burn model in adult mice for studies of cardiac function and cardiomyocyte cellular function.
- Clinical expert round table discussion (session 5) at the Margaux Conference on Critical Illness: outcomes of clinical trials in sepsis: lessons learned.
- Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional st...
- The systemic inflammatory response syndrome (SIRS): immunology and potential immunotherapy.
- A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.
- Calcium antagonists improve cardiac mechanical performance after thermal trauma.
- Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha.
- Pharmacokinetics and pharmacodynamics of milrinone lactate in pediatric patients with septic shock.
- Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte cytokine secretion.
- Thermal injury alters myocardial sarcoplasmic reticulum calcium channel function.
- Magnetic resonance imaging and invasive evaluation of development of heart failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha.
- Meningococcemia as a model for testing the hypothesis of antisepsis therapies.
- Genetic sequences and transcriptional regulation of the TNFA promoter: comparison of human and baboon.
- Randomized, placebo-controlled, double blinded trial of dexamethasone in African children with sepsis.
Schools
University of Texas Southwestern Medical Center At Dallas
Dallas Co Hp Parkland Mem
University Tx Southwestern Med School
Doctors Specialties
- Pediatric Critical Care Medicine
- Pediatrics
Accepted Insurances
Education
-
University of Texas Southwestern Medical School
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