Chief, Division of Geriatrics and Palliative Medicine, University at Buffalo
Internal Medicine
Dr. Bruce R. Troen, MD
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Bruce R. Troen, MD practices Internal Medicine. He attended Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received 9 awards: "Best Paper Award", "Plenary Poster Session presentation", "Florence A. Carter Grant", "Bristol Myers Award for Excellence in Oncology Research", "FIRST Award, NCI, NIH", "Research Sponsor of Michael Chang", "American Federation for Aging Research Grantee", "Geriatric Fellowship" and "Soma Weiss Award Presentation". Bruce R. Troen, MD has written publications. He has 47 publications published with PubMed. The lastest publication is: 'The Gene Construction Kit. DNA sequence analysis and presentation.'
Publications
- Do vitamin d levels influence the risk of diabetes mellitus and play a role in healthier aging?
- Retinoic acid inhibits NFATc1 expression and osteoclast differentiation.
- The response of elderly veterans to daily vitamin D3 supplementation of 2,000 IU: a pilot efficacy study.
- Some new food for thought: the role of vitamin D in the mental health of older adults.
- Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome.
- Hypovitaminosis D: a widespread epidemic.
- Fat and inflammaging: a dual path to unfitness in elderly people?
- Functional grouping of osteoclast genes revealed through microarray analysis.
- Emerging therapies to treat frailty syndrome in the elderly.
- Osteoporosis in older people: a tale of two studies (and three treatments).
- The regulation of cathepsin K gene expression.
- RANK ligand and interferon gamma differentially regulate cathepsin gene expression in pre-osteoclastic cells.
- RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation.
- Molecular cloning, expression, and function of osteoclastic calcineurin Aalpha.
- The biology of aging.
- Cathepsin K, osteoclastic resorption, and osteoporosis therapy.
- Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts.
- Prevention and treatment of senile osteoporosis and hip fractures.
- Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand.
- The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
- Treatment for osteoporosis in Australian residential aged care facilities: consensus recommendations for fracture prevention.
- Hypovitaminosis D in the elderly: from bone to brain.
- AP-1 stimulates the cathepsin K promoter in RAW 264.7 cells.
- Molecular mechanisms underlying osteoclast formation and activation.
- The role of cathepsin K in normal bone resorption.
- Plasma epinephrine and control of plasma renin activity: possible extrarenal mechanisms.
- Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.
- Use of a cloned multidrug resistance gene for coamplification and overproduction of major excreted protein, a transformation-regulated secreted acid protease.
- Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
- Colony screening of genomic cosmid libraries.
- Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.
- Effect of age on the 3,5,3''-tri-iodothyronine-induced increase in sugar uptake in rat thymocytes.
- Effects of age and sex on certain metabolic functions and mitogenic activity in rat thymocytes.
- Studies of the human testis. IV. Testicular 20 alpha-hydroxysteroid dehydrogenase and steroid 17 alpha-hydroxylase.
- Sympathetic nervous system and aging in man.
- Influence of age and sex on the concentrations of thyroid hormone in serum in the rat.
- Regulation of cathepsin D gene expression in HL-60 cells by retinoic acid and calcitriol.
- Phorbol ester stimulated cathepsin L expression in U937 cells.
- Comparative responsiveness of HL-60, HL-60R, and HL-60R+ (LRARSN) cells to retinoic acid, calcitriol, 9 cis-retinoic acid, and sodium butyrate.
- Cloning, genomic organization, and chromosomal localization of human cathepsin L.
- The Gene Construction Kit. DNA sequence analysis and presentation.
- CD38/ADP-ribosyl cyclase: A new role in the regulation of osteoclastic bone resorption.
- Differentiating agents regulate cathepsin B gene expression in HL-60 cells.
- Transcription of human cathepsin B is mediated by Sp1 and Ets family factors in glioma.
- Macrophage colony-stimulating factor suppresses osteoblast formation.
- New insights into the regulation of cathepsin K gene expression by osteoprotegerin ligand.
Schools
Harvard Medical School
Barnes HospWashington University School Med
Doctors Specialties
- Geriatric Medicine
- Internal Medicine
Accepted Insurances
Awards
- Best Paper Award
- Plenary Poster Session presentation
- Florence A. Carter Grant
- Bristol Myers Award for Excellence in Oncology Research
- FIRST Award, NCI, NIH
- Research Sponsor of Michael Chang
- American Federation for Aging Research Grantee
- Geriatric Fellowship
- Soma Weiss Award Presentation
Education
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University of Michigan Hospitals and Health Centers -
Washington University - Barnes-Jewish Hospital -
Harvard Medical School
Hospital
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Miami Veterans Affairs Healthcare System
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