Mary K. Iacocca Professor of Medicine, Joslin Diabetes Center
Endocrinology
Dr. C R. Kahn, MD
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Kahn works in the field of Endocrinology. He researched medicine at University of Louisville School of Medicine. University of Louisville School of Medicine is ranked 83/0 in Research/PrimaryCare. He received awards:"Fellow (FACP)" and "Elected Member". C R. Kahn, MD is a published doctor. He has 101 publications published. The most current publication "Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease."
Publications
- Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance.
- Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.
- Effect of Cholesterol Reduction on Receptor Signaling in Neurons.
- Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.
- Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.
- Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells.
- Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.
- Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.
- Insulin Action in Brain Regulates Systemic Metabolism and Brain Function.
- p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.
- A Zebrafish Embryo Culture System Defines Factors that Promote Vertebrate Myogenesis across Species.
- Thioesterase Superfamily Member 2/Acyl-CoA Thioesterase 13 (Them2/Acot13) Regulates Adaptive Thermogenesis in Mice.
- Shox2 is a molecular determinant of depot-specific adipocyte function.
- Sirt3 Regulates Metabolic Flexibility of Skeletal Muscle through Reversible Enzymatic Deacetylation.
- Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging.
- Vascular endothelial growth factor is important for brown adipose tissue development and maintenance.
- Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function.
- Mitochondria, obesity and aging.
- Lessons on Conditional Gene Targeting in Mouse Adipose Tissue.
- PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans.
- Metabolic syndrome: is nlrp3 inflammasome a trigger or a target of insulin resistance?
- Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors.
- Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
- Interview: C. Ronald Kahn. Interview by Misia Landau.
- PI 3-kinase regulatory subunits as regulators of the unfolded protein response.
- Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
- Diabetes and insulin in regulation of brain cholesterol metabolism.
- A systems biology approach identifies inflammatory abnormalities between mouse strains prior to development of metabolic disease.
- Insulin signaling to the glomerular podocyte is critical for normal kidney function.
- Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.
- Divergent roles of growth factors in the GnRH regulation of puberty in mice.
- The role and importance of brown adipose tissue in energy homeostasis.
- The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.
- Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma.
- Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.
- Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.
- Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.
- Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice.
- Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
- Adipose depots possess unique developmental gene signatures.
- Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.
- Leptin therapy for type 1 diabetes gains traction.
- A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
- Insulin enhances glucose-stimulated insulin secretion in healthy humans.
- Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.
- A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.
- High baseline vitamin C levels do not prevent a positive outcome of a lifestyle intervention: response to Thamer et al.
- Health care reform--need for less emotion and more science.
- Antioxidants prevent health-promoting effects of physical exercise in humans.
- Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
- Identification and importance of brown adipose tissue in adult humans.
- Beta-Cell hyperplasia induced by hepatic insulin resistance: role of a liver-pancreas endocrine axis through insulin receptor A isoform.
- Sex and depot differences in adipocyte insulin sensitivity and glucose metabolism.
- Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death.
- Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle.
- Medicine. Can we nip obesity in its vascular bud?
- The emerging genetic architecture of type 2 diabetes.
- Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
- Hepatic insulin resistance directly promotes formation of cholesterol gallstones.
- Central insulin action regulates peripheral glucose and fat metabolism in mice.
- Beneficial effects of subcutaneous fat transplantation on metabolism.
- Impaired sodium excretion and increased blood pressure in mice with targeted deletion of renal epithelial insulin receptor.
- Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance.
- Dissection of the insulin signaling pathway via quantitative phosphoproteomics.
- Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
- Rad GTPase deficiency leads to cardiac hypertrophy.
- IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
- Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
- Mitochondrial proton leak in obesity-resistant and obesity-prone mice.
- Developmental origin of fat: tracking obesity to its source.
- TRB3 blocks adipocyte differentiation through the inhibition of C/EBPbeta transcriptional activity.
- Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
- High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
- SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
- Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
- Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.
- Ephs and ephrins keep pancreatic Beta cells connected.
- The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.
- Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function.
- Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice.
- Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
- Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
- Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c.
- Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta.
- Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.
- Evidence for a role of developmental genes in the origin of obesity and body fat distribution.
- Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis.
- Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and i...
- Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.
- Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.
- Analysis of gene expression in pathophysiological states: balancing false discovery and false negative rates.
- From mice to men: insights into the insulin resistance syndromes.
- Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
- Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess.
- Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.
- Suppression of aging in mice by the hormone Klotho.
- Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
- Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.
- Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia.
- Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.
Schools
University of Louisville School of Medicine
Barnes Jewish Hospital
National Institute Arthrit Metab and Digest Dis
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Awards
- Fellow (FACP)
- Elected Member
Education
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Washington University - Barnes-Jewish Hospital -
University of Louisville School of Medicine
Hospital
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Brigham and Women's Hospital -
Beth Israel Deaconess Medical Center
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