Associate Professor of Medicine, Pharmacology, and Cell and Developmental Biology.
Cardiology
Dr. Charles C. Hong, MD
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Charles C. Hong, MD is an expert in the field of Cardiology. He researched medicine at Yale University School of Medicine. Yale University School of Medicine is one of the top medical schools in the US. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care He over the years received 10 awards: "Fellow, American Heart Association", "American Society for Clinical Investigation Inductee", "VA Career Development Transition Award", "Cali Family Foundation Development Award", "GlaxoSmithKline Young Investigator Award", "Irving H. Page Young Investigator Award Finalist", "Sarnoff Scholar Award", "William Schreyer Fellow Award", "Yale MD-PhD Prize" and "Sarnoff Fellowship". Dr. Charles C. Hong is a published doctor and has 72 publications published. The lastest was: 'The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis.'
Publications
- Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis.
- Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein.
- Regenerative chemical biology: current challenges and future potential.
- In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors.
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.
- Large scale zebrafish-based in vivo small molecule screen.
- Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full.
- Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma.
- Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
- High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility.
- Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status.
- Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth.
- Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes.
- Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.
- Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques.
- Whole exome sequencing identifies a causal RBM20 mutation in a large pedigree with familial dilated cardiomyopathy.
- A temperature-sensitive, self-adhesive hydrogel to deliver iPSC-derived cardiomyocytes for heart repair.
- Preface. Chemical biology.
- An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition.
- PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper.
- Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration.
- BMP type I receptor inhibition reduces heterotopic [corrected] ossification.
- Inhibition of BMP signaling suppresses metastasis in mammary cancer.
- Screening for Acute IKr Block is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current.
- Identification of a Common Wnt Associated Genetic Signature Across Multiple Cell Types in Pulmonary Arterial Hypertension.
- Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling.
- Bone morphogenetic protein-focused strategies to induce cytotoxicity in lung cancer cells.
- An unusual mosaic protein with a protease domain, encoded by the nudel gene, is involved in defining embryonic dorsoventral polarity in Drosophila.
- ZIP4 is a Novel Diagnostic and Prognostic Marker in Human Pancreatic Cancer: A Systemic Comparison Between EUS-FNA and Surgical Specimens.
- Making Models Work: Library Annotation through Phenoclustering.
- Selective small molecule targeting beta-catenin function discovered by in vivo chemical genetic screen.
- Autotaxin signaling governs phenotypic heterogeneity in visceral and parietal mesothelia.
- Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine ...
- Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines.
- Stem cell-derived cardiomyocytes as a tool for studying proarrhythmia: a better canary in the coal mine?
- A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.
- Mixing of the old with the new: nanoparticle-mediated pioglitazone delivery to enhance therapeutic neovascularization.
- DMH1, a Highly Selective Small Molecule BMP Inhibitor Promotes Neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 Expression during Neural Induction.
- DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells.
- Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis.
- BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFbeta receptor to promote invasion.
- Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation.
- The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.
- Pharmacologic inhibition of hepcidin expression reverses anemia of chronic disease in rats.
- Application of small organic molecules reveals cooperative TGFbeta and BMP regulation of mesothelial cell behaviors.
- Familial evaluation for diagnosis of arrhythmogenic right ventricular dysplasia.
- Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.
- Multi-step usage of in vivo models during rational drug design and discovery.
- Modified mouse embryonic stem cell based assay for quantifying cardiogenic induction efficiency.
- Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/beta-catenin signaling.
- Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.
- BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.
- sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair.
- Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells.
- Serial observations and mutational analysis of an adoptee with family history of hypertrophic cardiomyopathy.
- Early mortality and cardiorespiratory failure in patients with fibrodysplasia ossificans progressiva.
- Applications of small molecule BMP inhibitors in physiology and disease.
- Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice.
- Large-scale small-molecule screen using zebrafish embryos.
- Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specificati...
- Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.
- Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells.
- Signal transduction by a protease cascade.
- The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis.
- Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract.
- Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats.
- cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2.
- High content screening for modulators of cardiovascular or global developmental pathways in zebrafish.
- Practical strategies for small-molecule probe development in chemical biology.
- BMP Pathway Regulation of and by Macrophages.
- Bone morphogenetic proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion.
Schools
Yale University School Of Medicine
Yale New Haven Hospital
Massachusetts General Hospital
Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Fellow, American Heart Association
- American Society for Clinical Investigation Inductee
- VA Career Development Transition Award
- Cali Family Foundation Development Award
- GlaxoSmithKline Young Investigator Award
- Irving H. Page Young Investigator Award Finalist
- Sarnoff Scholar Award
- William Schreyer Fellow Award
- Yale MD-PhD Prize
- Sarnoff Fellowship
Education
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Massachusetts General Hospital -
Yale-New Haven Hospital -
Yale University School of Medicine
Hospital
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Vanderbilt Hospital and Clinics