Thomas W. Smith Professor of Medicine, Brigham and Women's Hospital
Cardiology
Dr. Christine E. Seidman, MD
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Christine Seidman is an expert in the field of Cardiology. She went to medical school at George Washington University School of Medicine. George Washington University School of Medicine is ranked 67 in research and 0 in primary care medicine She received awards:"Elected Member" and "Investigator". Christine E. Seidman is a published doctor as well. She has 101 publications published. The latest was: A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Publications
- A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic Cardiomyopathy in mice.
- Using Next-generation RNA Sequencing to Examine Ischemic Changes Induced by Cold Blood Cardioplegia on the Human Left Ventricular Myocardium Transcriptome.
- Results of clinical genetic testing of 2,912 probands with hypertrophic Cardiomyopathy: expanded panels offer limited additional sensitivity.
- Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic Cardiomyopathy in heterozygous mice.
- Diltiazem Treatment for Pre-Clinical Hypertrophic Cardiomyopathy Sarcomere Mutation Carriers: A Pilot Randomized Trial to Modify Disease Expression.
- Echocardiography and Cardiac MRI in Mutation-Negative Hypertrophic Cardiomyopathy in an Older Patient: A Case Defining the Need for ICD.
- Increased Burden of Cardiovascular Disease in Carriers of APOL1 Genetic Variants.
- Effects of losartan on left ventricular hypertrophy and fibrosis in patients with nonobstructive hypertrophic Cardiomyopathy.
- Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.
- An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: Applications in mice with bone property altering Lrp5 mutations.
- Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy.
- HOXA2 Haploinsufficiency in Dominant Bilateral Microtia and Hearing Loss.
- De novo mutations in histone-modifying genes in congenital heart Disease.
- Genetics of congenital heart Disease: the glass half empty.
- Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated Cardiomyopathy.
- Genetic and environmental risk factors in congenital heart Disease functionally converge in protein networks driving heart development.
- Genetic testing for dilated Cardiomyopathy in clinical practice.
- Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury.
- 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy A Report of the American College of Cardiology Foundation/American Heart Associa...
- 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary A Report of the American College of Cardiology Foundation/Ame...
- Polycomb repressive complex 2 regulates normal development of the mouse Heart.
- Heterozygosity for a Loss-of-Function Mutation in GALNT2 Improves Plasma Triglyceride Clearance in Man.
- CD36 overexpression predisposes to Arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis.
- 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology Foundation/Am...
- 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology Foundation/American Heart Associ...
- Brazilian urban population genetic structure reveals a high degree of admixture.
- Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis.
- Identifying sarcomere gene mutations in hypertrophic Cardiomyopathy: a personal history.
- Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac Valve development. [corrected]
- Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
- Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary Coronary artery bypass graft surgery.
- Activation of multiple signaling pathways causes developmental defects in mice with a Noonan Syndrome–associated Sos1 mutation.
- Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice.
- Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic Cardiomyopathy.
- Cardiac fibrosis in mice with hypertrophic Cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β.
- Research priorities in hypertrophic Cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.
- Myocardial fibrosis as an early manifestation of hypertrophic Cardiomyopathy.
- Sarcomere gene mutations in hypertrophy and Heart failure.
- Short communication: the cardiac myosin binding protein C Arg502Trp mutation: a common cause of hypertrophic Cardiomyopathy.
- A novel custom resequencing array for dilated Cardiomyopathy.
- Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic Cardiomyopathy.
- Genetics of hypertrophic Cardiomyopathy.
- Familial dilated Cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated Cardiomyopathy.
- Loss-of-function mutations in the PRPS1 gene cause a type of nonsyndromic X-linked sensorineural deafness, DFN2.
- Ca2+ dysregulation in Ryr1(I4895T/wt) mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods.
- Variation in the 4q25 chromosomal locus predicts Atrial fibrillation after coronary artery bypass graft surgery.
- Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat.
- Locus for familial migrainous vertigo Disease maps to chromosome 5q35.
- De novo copy number variants identify new genes and loci in isolated sporadic tetralogy of Fallot.
- Filter-based hybridization capture of subgenomes enables resequencing and copy-number detection.
- Sequencing of TGF-beta pathway genes in familial cases of intracranial Aneurysm.
- Cardiac myosin binding protein-C is essential for thick-filament stability and flexural rigidity.
- Natriuretic peptide system gene variants are associated with ventricular dysfunction after Coronary artery bypass grafting.
- Clinical outcome and phenotypic expression in LAMP2 Cardiomyopathy.
- Pheochromocytoma-induced Cardiomyopathy is modulated by the synergistic effects of cell-secreted factors.
- Genomewide linkage in a large Caucasian family maps a new locus for intracranial Aneurysms to chromosome 13q.
- How should hypertrophic Cardiomyopathy be classified?: What's in a name? Dilemmas in nomenclature characterizing hypertrophic Cardiomyopathy and left ventricular hyper...
- Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
- Shared genetic causes of cardiac hypertrophy in children and adults.
- Severe heart failure and early mortality in a double-mutation mouse model of familial hypertrophic Cardiomyopathy.
- Myofilament mechanical performance is enhanced by R403Q myosin in mouse myocardium independent of sex.
- Comparative proteomics profiling of a phospholamban mutant mouse model of dilated Cardiomyopathy reveals progressive intracellular stress responses.
- Eya4-deficient mice are a model for heritable otitis media.
- Reversibility of PRKAG2 glycogen-storage Cardiomyopathy and electrophysiological manifestations.
- The role of cardiac troponin T quantity and function in cardiac development and dilated Cardiomyopathy.
- Genetic basis of hypertrophic Cardiomyopathy: from bench to the clinics.
- An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line.
- Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
- A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
- Polony multiplex analysis of gene expression (PMAGE) in mouse hypertrophic Cardiomyopathy.
- Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage.
- AMP-activated protein kinase in the heart: role during health and Disease.
- Missense mutations in the BCS1L gene as a cause of the Björnstad Syndrome.
- Cardiac myosin binding protein C phosphorylation is cardioprotective.
- Cardiac myosin missense mutations cause dilated Cardiomyopathy in mouse models and depress molecular motor function.
- Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
- A contemporary approach to hypertrophic Cardiomyopathy.
- Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study.
- Novel locus for an inherited Cardiomyopathy maps to chromosome 7.
- Cardiovascular genomics.
- Somatic events modify hypertrophic Cardiomyopathy pathology and link hypertrophy to arrhythmia.
- Cardiac myosin-binding protein-C phosphorylation and cardiac function.
- Increased alpha2 subunit-associated AMPK activity and PRKAG2 Cardiomyopathy.
- Gene mutations in apical hypertrophic Cardiomyopathy.
- N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity.
- Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.
- Mutation in the transcriptional coactivator EYA4 causes dilated Cardiomyopathy and sensorineural hearing loss.
- Genetic causes of human Heart failure.
- The PTPN11 gene is not implicated in nonsyndromic hypertrophic Cardiomyopathy.
- Glycogen storage Diseases presenting as hypertrophic cardiomyopathy.
- The genetic basis for cardiac remodeling.
- Proposal for contemporary screening strategies in families with hypertrophic Cardiomyopathy.
- Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
- Effect of cardiac myosin binding protein-C on mechanoenergetics in mouse myocardium.
- Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening.
- Electrophysiologic characterization and postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White Syndrome.
- Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic Cardiomyopathy.
- Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage Cardiomyopathy.
- Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular Failure in genetic hypertrophy.
- IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis.
Schools
George Washington University School Of Medicine
Johns Hopkins Hospital
Massachusetts General Hospital
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardioverter-Defibrillator or Pacemaker Insertion, Removal or Repair
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Conditions Treated
- Aortic Aneurysm
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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Massachusetts General Hospital -
Johns Hopkins University -
George Washington University School of Medicine
Hospital
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Brigham and Women's Hospital
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