Physician
Hematology
Dr. Christopher A. Slapak, MD
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Christopher A. Slapak, MD works in the field of Hematology. He went to medical school at University of Chicago Pritzker School of Medicine. University of Chicago Pritzker School of Medicine has a rank of 10 in research and a 19 in primary care Doctor Christopher A. Slapak, MD is a published doctor as well. He has 35 publications published. The latest was: Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance.
Publications
- Phase 1/2 Study of Ocaratuzumab, an Fc-Engineered Humanized Anti-CD20 Monoclonal Antibody, in Low-Affinity FcγRIIIa Patients with Previously Treated Follicular Lymphoma.
- A Phase 1 Study of AME-133v (LY2469298) an Fc-Engineered Humanized Monoclonal Antibody in Fc?RIIIa-Genotyped Patients with Previously Treated Follicular Lymphoma.
- Phase I study of oral gemcitabine prodrug (LY2334737) alone and in combination with erlotinib in patients with advanced solid tumors.
- A phase I study of tasisulam sodium (LY573636 sodium), a novel anticancer compound in patients with refractory solid tumors.
- Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
- Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell Lymphoma.
- Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies.
- An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines.
- A Phase I trial of a potent P-glycoprotein inhibitor, zosuquidar trihydrochloride (LY335979), administered intravenously in combination with doxorubicin in patients wi...
- A phase I trial of a potent P-glycoprotein inhibitor, Zosuquidar.3HCl trihydrochloride (LY335979), administered orally in combination with doxorubicin in patients with...
- Identification and characterization of the canine multidrug resistance-associated protein.
- A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells.
- Treatment of acute myeloid leukemia in the elderly with low-dose cytarabine, hydroxyurea, and calcitriol.
- Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts.
- Expression of c-fos precedes MDR3 in vincristine and adriamycin selected multidrug resistant murine erythroleukemia cells.
- Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance.
- A phase I-II trial of continuous-infusion cisplatin, continuous-infusion 5-fluorouracil, and VP-16 in colorectal carcinoma.
- A phase II trial of continuous infusion cisplatin and 5-fluorouracil with oral calcium leucovorin in colorectal carcinoma.
- Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistance-associated pr...
- A syndrome of lymphoblastic Lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic...
- Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation.
- Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-...
- Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells.
- Increased efflux of vincristine, but not of daunorubicin, associated with the murine multidrug resistance protein (MRP).
- Differential changes in genome structure and expression of the mdr gene family in multidrug-resistant murine erythroleukemia cell lines.
- Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: participation of lysosomes.
- Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo.
- Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
- Overexpression of the multidrug resistance-associated protein (MRP) gene in vincristine but not doxorubicin-selected multidrug-resistant murine erythroleukemia cells.
- Role of P-glycoprotein in dolastatin 10 resistance.
- Modulation by LY335979 of P-glycoprotein function in multidrug-resistant cell lines and human natural killer cells.
- Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- bindin...
- Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours.
- Tumor survivin is downregulated by the antisense oligonucleotide LY2181308: a proof-of-concept, first-in-human dose study.
Schools
U Of Chgo Div Of Bio Sci Pritzker Sch Of Med
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Leukocytosis
- Myelodysplastic Syndromes
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Doctors Specialties
- Hematology
- Medical Oncology
- Oncology
Accepted Insurances
Education
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Tufts Medical Center -
University of Chicago -
University of Chicago Pritzker School of Medicine
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