Professor, Medicine, University of Maryland School of Medicine
Infectious Disease
Dr. Christopher V. Plowe, MD
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Christopher V. Plowe practices Infectious Disease. He graduated from Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University is ranked 18/49 in Research/PrimaryCare. He over the years received 2 awards: "Elected Member" and "Investigator". Doctor Christopher V. Plowe, MD is also published. He has 101 publications published. The lastest publication: "Unidirectional dominance of cytoplasmic inheritance in two genetic crosses of Plasmodium falciparum.'
Publications
- A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment.
- Vaccine-Resistant Malaria.
- Designing malaria vaccines to circumvent antigen variability.
- Persistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi.
- Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype.
- Seroreactivity to a Large Panel of Field-Derived Plasmodium falciparum Apical Membrane Antigen 1 and Merozoite Surface Protein 1 Variants Reflects Seasonal and Lifetim...
- Controlled Human Malaria Infection of Tanzanians by Intradermal Injection of Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites.
- The return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi.
- Chloroquine-azithromycin combination antimalarial treatment decreases risk of respiratory and gastrointestinal tract infections in Malawian children.
- Malaria: Resistance nailed.
- Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection.
- Monitoring antifolate resistance in intermittent preventive therapy for malaria.
- Seroreactivity to Plasmodium falciparum Erythrocyte Membrane Protein 1 Intracellular Domain in Malaria-Exposed Children and Adults.
- Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.
- Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications.
- No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in mali.
- Antigen-Specific B Memory Cell Responses to Plasmodium falciparum Malaria Antigens and Schistosoma haematobium Antigens in Co-Infected Malian Children.
- Limited Geographical Origin and Global Spread of Sulfadoxine-Resistant dhps Alleles in Plasmodium falciparum Populations.
- The threat of artemisinin-resistant malaria.
- A field trial to assess a blood-stage malaria vaccine.
- Vaccine design: innovative approaches and novel strategies.
- Vaccines for Malaria: How Close Are We?
- A research agenda to underpin malaria eradication.
- Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites.
- Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.
- Plasmodium falciparum malaria challenge by the bite of aseptic Anopheles stephensi mosquitoes: results of a randomized infectivity trial.
- Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.
- High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children.
- The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria.
- Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development.
- A malaria vaccine for control: more progress.
- Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi.
- Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial.
- Monitoring and deterring drug-resistant malaria in the era of combination therapy.
- Platelet-mediated clumping of Plasmodium falciparum infected erythrocytes is associated with high parasitemia but not severe clinical manifestations of malaria in Afri...
- Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting.
- Malaria treatment efficacy among people living with HIV: the role of host and parasite factors.
- Selection of antifolate-resistant Plasmodium falciparum by sulfadoxine-pyrimethamine treatment and infectivity to Anopheles mosquitoes.
- Short report: rare Plasmodium falciparum merozoite surface protein 1 19-kda (msp-1(19)) haplotypes identified in Mali using high-throughput genotyping methods.
- Combination therapy for malaria: mission accomplished?
- Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali.
- Pneumocystis pneumonia in HIV-positive adults, Malawi.
- The Interaction between HIV and malaria in Africa.
- Return of chloroquine antimalarial efficacy in Malawi.
- Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children.
- Use of area under the curve to characterize transmission potential after antimalarial treatment.
- Cotrimoxazole prophylaxis and malaria in Africa: Have the important questions been answered?
- Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and...
- Observational cohort study of HIV-infected African children.
- Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence.
- Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi.
- Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children.
- Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease.
- Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children.
- HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparu...
- A community-based study of the incidence of trimethoprim-sulfamethoxazole-preventable infections in Malawian adults living with HIV.
- Community permission for medical research in developing countries.
- Mechanisms of resistance of malaria parasites to antifolates.
- Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria.
- Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones.
- Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria.
- Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria.
- Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.
- Impact of preseason treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali.
- Genetics of drug-resistant Plasmodium falciparum malaria in the Venezuelan state of Bolivar.
- Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America.
- Determinants of treatment response to sulfadoxine-pyrimethamine and subsequent transmission potential in falciparum malaria.
- Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
- Reduced T Regulatory Cell Response during Acute Plasmodium falciparum Infection in Malian Children Co-Infected with Schistosoma haematobium.
- Low infectivity of Plasmodium falciparum gametocytes to Anopheles gambiae following treatment with sulfadoxine-pyrimethamine in Mali.
- Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine.
- The evolution of drug-resistant malaria.
- Cell-mediated immunity elicited by the blood stage malaria vaccine apical membrane antigen 1 in Malian adults: results of a Phase I randomized trial.
- Genome-wide and fine-resolution association analysis of malaria in West Africa.
- A network to monitor antimalarial drug resistance: a plan for moving forward.
- The rationale and plan for creating a World Antimalarial Resistance Network (WARN).
- World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs.
- World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.
- World Antimalarial Resistance Network (WARN) IV: clinical pharmacology.
- Safety and allele-specific immunogenicity of a malaria vaccine in Malian adults: results of a phase I randomized trial.
- Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia.
- A high-throughput method for quantifying alleles and haplotypes of the malaria vaccine candidate Plasmodium falciparum merozoite surface protein-1 19 kDa.
- Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.
- A comparison of anemia in hemoglobin C and normal hemoglobin A children with Plasmodium falciparum malaria.
- Withdrawing antimalarial drugs: impact on parasite resistance and implications for malaria treatment policies.
- Incidence of severe Plasmodium falciparum malaria as a primary endpoint for vaccine efficacy trials in Bandiagara, Mali.
- Sustained clinical efficacy of sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Malawi after 10 years as first line treatment: five year prospective s...
- Monitoring antimalarial drug resistance: making the most of the tools at hand.
- Erythrocyte CR1 expression level does not correlate with a HindIII restriction fragment length polymorphism in Africans; implications for studies on malaria susceptibi...
- Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial.
- Identification of the Kna/Knb polymorphism and a method for Knops genotyping.
- Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci.
- Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with sev...
- The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses.
- Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications.
- Family satisfaction with psychiatric evaluations.
- Rehydration and maintenance therapy of cholera patients in Jakarta: citrate-based versus bicarbonate-based oral rehydration salt solution.
- Compliance and outcome of patients accompanied by relatives to evaluations.
- Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Afr...
- Unidirectional dominance of cytoplasmic inheritance in two genetic crosses of Plasmodium falciparum.
Schools
Weill Cornell Medical College
St LukeS Hospital
Doctors Specialties
- Infectious Disease Medicine
- Infectious Disease
Accepted Insurances
Awards
- Elected Member
- Investigator
Education
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St Luke's-Roosevelt Hospital Center -
Weill Cornell Medical College of Cornell University
Hospital
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University of Maryland Medical Center
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