Professor and Chair of Pathology, Case Western Reserve Univ./University Hospitals Case Medical Ct
Pathology
Dr. Clifford V. Harding III, MD
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Doctor Clifford V. Harding III, MD practices Pathology. He went to medical school at Washington University School of Medicine in St. Louis. He over the years received 6 awards: "Fellow", "Scholar", "Junior Faculty Research Award", "Experimental Pathologist-in-Training Award", "Phi Beta Kappa" and "Whos Who in Medicine and Healthcare". Clifford Harding is a published doctor. He published 88 publications, including: 'A critical role for alpha-synuclein in development and function of T lymphocytes.'
Publications
- A critical role for alpha-synuclein in development and function of T lymphocytes.
- Interferon-α inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling.
- TLR2-dependent ERK signaling in Mycobacterium tuberculosis-infected macrophages drives anti-inflammatory responses and inhibits Th1 polarization of responding T cells.
- Novel quorum-quenching agents promote MRSA wound healing and sensitize MRSA to β-lactam antibiotics.
- Mycobacterium tuberculosis Lipoprotein LprG Binds Lipoarabinomannan and Determines Its Cell Envelope Localization to Control Phagolysosomal Fusion.
- Plasmacytoid Dendritic Cells Mediate Synergistic Effects of HIV and Lipopolysaccharide on CD27+ IgD- Memory B Cell Apoptosis.
- TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
- Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis.
- Circulating CD4+ and CD8+ T cells are activated in IBD and are associated with plasma markers of inflammation.
- Interferon-? Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers.
- Exosomes: Looking back three decades and into the future.
- Impaired T cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes.
- Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation.
- TLR2 Signaling Depletes IRAK1 and Inhibits Induction of Type I IFN by TLR7/9.
- Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.
- Presentation of soluble antigens to CD8+ T cells by CpG oligodeoxynucleotide-primed human naive B cells.
- Mycobacterium tuberculosis lipoproteins directly regulate human memory CD4(+) T cell activation via Toll-like receptors 1 and 2.
- Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable o...
- Mycobacterium tuberculosis promotes HIV trans-infection and suppresses major histocompatibility complex class II antigen processing by dendritic cells.
- Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.
- Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9.
- CpG-B oligodeoxynucleotides inhibit TLR-dependent and -independent induction of type I IFN in dendritic cells.
- Presenting exogenous antigen to T cells.
- Choosing and preparing antigen-presenting cells.
- Mycobacterium tuberculosis cell wall glycolipids directly inhibit CD4+ T-cell activation by interfering with proximal T-cell-receptor signaling.
- Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells.
- Desensitization to type I interferon in HIV-1 infection correlates with markers of immune activation and disease progression.
- P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1.
- TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
- Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.
- Impaired naive and memory B-cell responsiveness to TLR9 stimulation in human immunodeficiency virus infection.
- Modulation of pulmonary dendritic cell function during mycobacterial infection.
- Class II MHC antigen processing in phagosomes.
- Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2.
- CCAAT/enhancer-binding protein beta and delta binding to CIITA promoters is associated with the inhibition of CIITA expression in response to Mycobacterium tuberculosi...
- Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
- CpG-B ODNs potently induce low levels of IFN-alphabeta and induce IFN-alphabeta-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs.
- gp96 leads the way for toll-like receptors.
- Class II MHC antigen presentation defect in neonatal monocytes is not correlated with decreased MHC-II expression.
- Phosphatidylinositol mannoside from Mycobacterium tuberculosis binds alpha5beta1 integrin (VLA-5) on CD4+ T cells and induces adhesion to fibronectin.
- Mycobacterium tuberculosis LprA is a lipoprotein agonist of TLR2 that regulates innate immunity and APC function.
- The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-l...
- Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling.
- Efficient metabolic engineering of GM3 on tumor cells by N-phenylacetyl-D-mannosamine.
- Role of phagosomes and major histocompatibility complex class II (MHC-II) compartment in MHC-II antigen processing of Mycobacterium tuberculosis in human macrophages.
- The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse model.
- Enhancement of dendritic cell antigen cross-presentation by CpG DNA involves type I IFN and stabilization of class I MHC mRNA.
- Mouse endothelial cells cross-present lymphocyte-derived antigen on class I MHC via a TAP1- and proteasome-dependent pathway.
- Mycobacterium tuberculosis heat shock fusion protein enhances class I MHC cross-processing and -presentation by B lymphocytes.
- Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in human immunodeficiency virus disease and is at least partially m...
- Development of immune-complex glomerulonephritis in athymic mice: T cells are not required for the genesis of glomerular injury.
- Phagosomal processing of Mycobacterium tuberculosis antigen 85B is modulated independently of mycobacterial viability and phagosome maturation.
- Prolonged toll-like receptor signaling by Mycobacterium tuberculosis and its 19-kilodalton lipoprotein inhibits gamma interferon-induced regulation of selected genes i...
- Bacterial heat shock proteins enhance class II MHC antigen processing and presentation of chaperoned peptides to CD4+ T cells.
- Mycobacterium tuberculosis LprG (Rv1411c): a novel TLR-2 ligand that inhibits human macrophage class II MHC antigen processing.
- Bacterial heat shock proteins promote CD91-dependent class I MHC cross-presentation of chaperoned peptide to CD8+ T cells by cytosolic mechanisms in dendritic cells ve...
- Inhibition of major histocompatibility complex II expression and antigen processing in murine alveolar macrophages by Mycobacterium bovis BCG and the 19-kilodalton myc...
- In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4+ T cell help.
- CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro.
- CpG DNA induces a class II transactivator-independent increase in class II MHC by stabilizing class II MHC mRNA in B lymphocytes.
- The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2.
- Alternate class I MHC antigen processing is inhibited by Toll-like receptor signaling pathogen-associated molecular patterns: Mycobacterium tuberculosis 19-kDa lipopro...
- Inhibition of IFN-gamma-induced class II transactivator expression by a 19-kDa lipoprotein from Mycobacterium tuberculosis: a potential mechanism for immune evasion.
- Antigen processing of the heptavalent pneumococcal conjugate vaccine carrier protein CRM(197) differs depending on the serotype of the attached polysaccharide.
- Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH.
- ATP and control of intracellular growth of mycobacteria by T cells.
- Phosphoantigen presentation by macrophages to mycobacterium tuberculosis--reactive Vgamma9Vdelta2+ T cells: modulation by chloroquine.
- Regulation of class II MHC expression in APCs: roles of types I, III, and IV class II transactivator.
- MHC molecules and microbial antigen processing in phagosomes.
- Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection.
- Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.
- Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling.
- Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammat...
- T-cell hybridomas from HLA-transgenic mice as tools for analysis of human antigen processing.
- Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
- TLR9 stimulation drives naïve B cells to proliferate and to attain enhanced antigen presenting function.
- Antigen processing and CD24 expression determine antigen presentation by splenic CD4+ and CD8+ dendritic cells.
- Interferon-alphabeta mediates partial control of early pulmonary Mycobacterium bovis bacillus Calmette-Guérin infection.
- Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.
- Antigen processing and recognition.
- Localization of peptide/MHC class II complexes in macrophages following antigen processing of viable Streptococcus pyogenes.
- Interaction of bacteria with antigen presenting cells: influences on antigen presentation and antibacterial immunity.
- Differences in antigen processing with haplotype-mismatched MHC class II heterodimers: Aalpha(d)Abeta(b) heterodimers participate in early endosomal processing.
- Determinants of protection among HIVâexposed seronegative persons: an overview.
- Synthesis and immunological properties of N-modified GM3 antigens as therapeutic cancer vaccines.
- Preparation and immunological studies of protein conjugates of N -acylneuraminic acids.
- Electroporation of exogenous antigen into the cytosol for antigen processing and class I major histocompatibility complex (MHC) presentation: weak base amines and hypo...
Schools
Washington Center School of Medicine
Doctors Specialties
- Anatomic Pathology
- Immunology
- Pathology
Accepted Insurances
Awards
- Fellow
- Scholar
- Junior Faculty Research Award
- Experimental Pathologist-in-Training Award
- Phi Beta Kappa
- Whos Who in Medicine and Healthcare
Education
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Washington University - Barnes-Jewish Hospital -
Washington University School of Medicine in St. Louis -
Harvard College
Hospital
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University Hospitals Case Medical Center
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