Professor of Medicine, Brigham and Women's Hospital
Oncology
Dr. Dan L. Longo, MD
Longo is an expert in the field of Oncology. He went to medical school at University of Missouri-Columbia School of Medicine. He received 1 awards: "Whos Who in Medicine and Healthcare". Dr. Dan L. Longo has written publications. He has 100 publications published with PubMed. The lastest paper is: 'Improving Prospects for Targeting RAS.'
Publications
- Improving Prospects for Targeting RAS.
- Combined-Modality Therapy for Early-Stage Diffuse Large B-Cell Lymphoma: Knowing When to Quit.
- Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
- Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions.
- Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice.
- Chromatin Properties of Regulatory DNA Probed by Manipulation of Transcription Factors.
- Pharmacodynamic biomarkers: falling short of the mark?
- Multiple Myeloma in the Very Old: An IASIA Conference Report.
- Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.
- Role of mitofusin 2 (Mfn2) in controlling cellular proliferation.
- Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy.
- Personality Traits and Leptin.
- Murine natural killer cell licensing and regulation by T regulatory cells in viral responses.
- Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells.
- Treatment of advanced hodgkin Lymphoma: the more things change, the more they stay the same.
- Genetic variation associated with circulating monocyte count in the eMERGE Network.
- Relationship between mean corpuscular volume and cognitive performance in older adults.
- Transforming growth factor β1 (TGF-β1) suppresses growth of B-cell Lymphoma cells by p14(ARF)-dependent regulation of mutant p53.
- Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based Cancer immunotherapy.
- Neoplastic "Black Ops": Cancer's subversive tactics in overcoming host defenses.
- Cancer immunotherapy: Are we there yet?
- Follicular Lymphoma: to treat or not to treat is no longer the question.
- Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing.
- Distinctive immunoregulatory effects of adenosine on T cells of older humans.
- Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats.
- Redirecting T Cells.
- Multiple Loci are associated with white blood cell phenotypes.
- Identification of nine novel Loci associated with white blood cell subtypes in a Japanese population.
- Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis.
- Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide.
- Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor.
- Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18.
- Distinctive mechanism for sustained TGF-β signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-β receptors.
- Involvement of mTOR in CXCL12 Mediated T Cell Signaling and Migration.
- Transcriptional regulation of BRCA1 expression by a metabolic switch.
- Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart Disease: A random-effects modeling approach.
- Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial.
- Gender specificity of altered human immune cytokine profiles in aging.
- Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men.
- New therapies for castration-resistant prostate Cancer.
- Human CD4- 8- T cells are a distinctive immunoregulatory subset.
- Proinflammatory state, hepcidin, and Anemia in older persons.
- Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain.
- Red cell distribution width and mortality in older adults: a meta-analysis.
- Transcriptional autoregulation by BRCA1.
- A genome-wide association analysis of serum iron concentrations.
- Blood stem cell transplantation in older patients.
- Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
- Telomere dynamics in aging: much ado about nothing?
- Late effects from radiation therapy: the hits just keep on coming.
- Red blood cell distribution width and the risk of death in middle-aged and older adults.
- From the guest editor: Hodgkin's Lymphoma: an overview.
- Role of chemotherapy in Hodgkin's Lymphoma.
- Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation.
- Immunity from smallpox vaccine persists for decades: a longitudinal study.
- Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and Anemia in adults: the Baltimore longitudinal study of aging.
- Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines.
- High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging.
- Hutchinson-Gilford progeria syndrome.
- Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives.
- Nrf2 mediates Cancer protection but not prolongevity induced by caloric restriction.
- Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk.
- Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women.
- Traf1 induction and protection from tumor necrosis factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation.
- Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell Lymphoma cell lines.
- The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1beta converting enzyme.
- Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's Disease models.
- A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults.
- IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy.
- Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus.
- Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation.
- Idiotype vaccination in follicular Lymphoma: knocking on the doorway to cure.
- Low testosterone levels and the risk of Anemia in older men and women.
- A report card for geriatric oncology: borderline pass, improvement needed.
- Interleukin-6 in aging and chronic Disease: a magnificent pathway.
- Transient improvement in cognitive function and synaptic plasticity in rats following Cancer chemotherapy.
- Proinflammatory state and circulating erythropoietin in persons with and without Anemia.
- Dual isotype expressing B cells [kappa(+)/lambda(+)] arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice.
- Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.
- Radiation therapy in Hodgkin Disease: why risk a Pyrrhic victory?
- Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular Lymphoma.
- Serum erythropoietin and aging: a longitudinal analysis.
- Closing in on a killer: Anemia in elderly people.
- Radiation therapy may improve survival of premenopausal women with breast Cancer involving axillary lymph nodes.
- Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.
- The origins of age-related proinflammatory state.
- Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR).
- Comparison of the effect of mutant and wild-type p53 on global gene expression.
- Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telangiectasia mutated kinase.
- Lymphoma and myeloma in older patients.
- Ammonium trichloro(dioxoethylene-o,o')tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop.
- Transcriptome analysis of mouse stem cells and early embryos.
- Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population.
- Radiation therapy in the treatment of Hodgkin's Disease--do you see what I see?
- Pneumococcal vaccination and revaccination of older adults.
- Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity.
- Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens.
- DR's orders: human antibody kills tumors by direct signaling.
- Activation-induced cell death of aggressive histology Lymphomas by CD40 stimulation: induction of bax.
Schools
University Of MissouriColumbia School Of Medicine
Peter Bent Brigham Hospital
National Cancer Institute
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Leukocytosis
- Lung Cancer
- View All
Doctors Specialties
- Medical Oncology
- Oncology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- BlueConnect HMO
- Blue with Managed Care Behavioral Health HMO
- Preferred Blue PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- First Health (Coventry Health Care) PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Neighborhood Health Plan
- Tufts Health Plans
- Tufts PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- Whos Who in Medicine and Healthcare
Education
-
Brigham and Women's Hospital -
University of Missouri-Columbia School of Medicine
Hospital
-
Brigham and Women's Hospital
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