Physician
Internal Medicine
Dr. David M. Antonetti, MD
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Doctor David M. Antonetti, MD is an expert in the field of Internal Medicine. He went to Georgetown University School of Medicine. Georgetown University School of Medicine is ranked 49/84 in Research/PrimaryCare. He received 1 awards: "CMS Meaningful Use Stage 1 Certification". Doctor David M. Antonetti, MD has written publications. He has 69 publications published with PubMed. The lastest publication is: 'Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retina...' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Algorithm for the Measure of Vitreous Hyperreflective Foci in Optical Coherence Tomographic Scans of Patients With Diabetic Macular Edema.
- Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.
- Ischemia-reperfusion injury induces occludin phosphorylation/ubiquitination and retinal vascular permeability in a VEGFR-2-dependent manner.
- Using the Past to Inform the Future: Anti-VEGF Therapy as a Road Map to Develop Novel Therapies for Diabetic Retinopathy.
- Glucocorticoid Induction of Occludin Expression and Endothelial Barrier Requires Transcription Factor p54 NONO.
- Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors.
- Mechanism of metabolic stroke and spontaneous cerebral hemorrhage in glutaric aciduria type I.
- Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury.
- High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx.
- Polychromatic Angiography for the Assessment of VEGF-Induced BRB Dysfunction in the Rabbit Retina.
- Usefulness of immunoblotting and Goldmann-Witmer coefficient for biological diagnosis of toxoplasmic retinochoroiditis.
- Eye vessels saved by rescuing their pericyte partners.
- Placenta growth factor-1 exerts time-dependent stabilization of adherens junctions following VEGF-induced vascular permeability.
- Occludin localizes to centrosomes and modifies mitotic entry.
- A three-pore model describes transport properties of bovine retinal endothelial cells in normal and elevated glucose.
- Alterations to the blood-retinal barrier in diabetes: cytokines and reactive oxygen species.
- The blood-retinal barrier: structure and functional significance.
- TNF-? signals through PKC?/NF-?B to alter the tight junction complex and increase retinal endothelial cell permeability.
- Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury.
- Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.
- A multistep validation process of biomarkers for preclinical drug development.
- Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response.
- Occludin phosphorylation and ubiquitination regulate tight junction trafficking and vascular endothelial growth factor-induced permeability.
- Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model.
- Identification and analysis of occludin phosphosites: a combined mass spectrometry and bioinformatics approach.
- Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach.
- Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches.
- Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element.
- Occludin independently regulates permeability under hydrostatic pressure and cell division in retinal pigment epithelial cells.
- Vascular permeability in ocular disease and the role of tight junctions.
- A prize catch for diabetic retinopathy.
- Ruboxistaurin for diabetic retinopathy.
- VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability.
- Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases.
- Diabetic retinopathy: seeing beyond glucose-induced microvascular disease.
- New insights for glutaric aciduria type I.
- Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin.
- A diet-induced mouse model for glutaric aciduria type I.
- Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation.
- Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy.
- Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells.
- The Ins2Akita mouse as a model of early retinal complications in diabetes.
- VEGF increases paracellular transport without altering the solvent-drag reflection coefficient.
- Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats.
- Regulation of tight junctions and loss of barrier function in pathophysiology.
- Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner.
- Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats.
- Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system.
- A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells.
- Isolation and characterization of retinal endothelial cells.
- Characterization of insulin signaling in rat retina in vivo and ex vivo.
- Diabetic retinopathy: more than meets the eye.
- Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells.
- Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin.
- Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons.
- New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets.
- Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.
- Shear stress regulates occludin content and phosphorylation.
- Retinal neurodegeneration: early pathology in diabetes.
- Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.
- Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.
- The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group.
- Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group.
- Molecular mechanisms of vascular permeability in diabetic retinopathy.
- Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver.
- Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeabi...
- Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retina...
- Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin.
Schools
Georgetown Univ Sch Of Med
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Georgetown University Hospital -
Georgetown University School of Medicine
Drug Facts
| NPI NUMBER | 1184781031 | |
| NPPES Provider LastName | ANTONETTI | |
| NPPES Provider FirstName | DAVID | |
| NPPES Provider ZIPCode | 222053609 | |
| NPPES Provider State | VA | |
| Specialty Description | Internal Medicine | |
| Total Claim Count | 1190.0 | |
| Distinct Opioid Count | 3.0 | |
| Opioid Claim Count | 78.0 | |
| Percent Opioid Claims | 6.55 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1184781031 |
| Last Name Of The Provider | ANTONETTI |
| First Name Of The Provider | DAVID |
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