Chair, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center
Pathology
Dr. David M. Engman, MD
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Dr. David M. Engman works in the field of Pathology. He attended University of Iowa Carver College of Medicine. University of Iowa Carver College of Medicine has a rank of 29 in research and a 16 in primary care He over the years received 4 awards: "Fellow", "Member", "Amgen Outstanding Investigator" and "Established Investigator". David Engman has written publications. He has 83 publications published with PubMed. The lastest publication is: 'TcDJ1, a putative mitochondrial DnaJ protein in Trypanosoma cruzi.' He is registered with Medicare and accepts Medicare payments.
Publications
- Sphingosine Kinase Regulates Microtubule Dynamics and Organelle Positioning Necessary for Proper G1/S Cell Cycle Transition in Trypanosoma brucei.
- Calcium-dependent membrane association of a flagellar calcium sensor does not require calcium binding.
- Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead.
- Depletion of regulatory T cells decreases cardiac parasitosis and inflammation in experimental Chagas disease.
- Acylation in trypanosomatids: an essential process and potential drug target.
- Endothelial transmigration by Trypanosoma cruzi.
- Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through MER Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction.
- (1)H, (15)N, and (13)C chemical shift assignments of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.
- Cardiac damage induced by immunization with heat-killed Trypanosoma cruzi is not antibody mediated.
- NMR structure of the calflagin Tb24 flagellar calcium binding protein of Trypanosoma brucei.
- Extracellular release of the glycosylphosphatidylinositol (GPI)-linked Leishmania surface metalloprotease, gp63, is independent of GPI phospholipolysis: implications f...
- Pathogenesis of Chagas heart disease: role of autoimmunity.
- Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63.
- Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists in experimental myocarditis.
- The significance of autoimmunity in the pathogenesis of Chagas heart disease.
- A novel reiterated family of transcribed oligo(A)-terminated, interspersed DNA elements in the genome of Trypanosoma cruzi.
- Captopril ameliorates myocarditis in acute experimental Chagas disease.
- Captopril prevents experimental autoimmune myocarditis.
- Killing of African trypanosomes by antimicrobial peptides.
- Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease.
- A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins.
- A flagellum-specific calcium sensor.
- Responsive microtubule dynamics promote cell invasion by Trypanosoma cruzi.
- Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression.
- Further thoughts on where we stand on the autoimmunity hypothesis of Chagas disease.
- Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry.
- Flagellar membrane trafficking in kinetoplastids.
- The major surface-metalloprotease of the parasitic protozoan, Leishmania, protects against antimicrobial peptide-induced apoptotic killing.
- Modulation of autoimmunity by treatment of an infectious disease.
- Treatment of experimental myocarditis via modulation of the renin-angiotensin system.
- Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis.
- Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei.
- Bioluminescent imaging of Trypanosoma cruzi infection.
- Structural insights into membrane targeting by the flagellar calcium-binding protein (FCaBP), a myristoylated and palmitoylated calcium sensor in Trypanosoma cruzi.
- Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.
- Chagas heart disease pathogenesis: one mechanism or many?
- Identification of a palmitoyl acyltransferase required for protein sorting to the flagellar membrane.
- Flagellar membrane localization via association with lipid rafts.
- Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection.
- Molecular mechanisms of protein and lipid targeting to ciliary membranes.
- Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.
- Calflagin inhibition prolongs host survival and suppresses parasitemia in Trypanosoma brucei infection.
- Composition and sensory function of the trypanosome flagellar membrane.
- Molecular mechanisms of host cell invasion by Trypanosoma cruzi.
- Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes.
- Global analysis of protein palmitoylation in African trypanosomes.
- Heat-killed Trypanosoma cruzi induces acute cardiac damage and polyantigenic autoimmunity.
- Gene profiling for assessment of cell-based therapies.
- Molecular determinants of ciliary membrane localization of trypanosoma cruzi flagellar calcium-binding protein.
- 83-kilodalton heat shock proteins of trypanosomes are potent peptide-stimulated ATPases.
- Specific functional domains of mitochondrial hsp70s suggested by sequence comparison of the trypanosome and yeast proteins.
- Human humoral immunity to hsp70 during Trypanosoma cruzi infection.
- The gene family encoding eggshell proteins of Schistosoma japonicum.
- Ubiquitin genes in trypanosomatidae.
- A novel flagellar Ca2+-binding protein in trypanosomes.
- Molecular cloning of mtp70, a mitochondrial member of the hsp70 family.
- Comparison of HSP70 genes from two strains of Trypanosoma cruzi.
- The 35-nucleotide spliced leader sequence is common to all trypanosome messenger RNA's.
- Trypanosoma cruzi exhibits inter- and intra-strain heterogeneity in molecular karyotype and chromosomal gene location.
- Comparison of the 24 kDa flagellar calcium-binding protein cDNA of two strains of Trypanosoma cruzi.
- A rapid method for protein localization in trypanosomes.
- Utility of recombinant flagellar calcium-binding protein for serodiagnosis of Trypanosoma cruzi infection.
- Molecular comparison of the mitochondrial and cytoplasmic hsp70 of Trypanosoma cruzi, Trypanosoma brucei and Leishmania major.
- Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast.
- Mitochondrial heat shock protein 70 is distributed throughout the mitochondrion in a dyskinetoplastic mutant of Trypanosoma brucei.
- Trypanosoma cruzi: accumulation of polycistronic hsp70 RNAs during severe heat shock.
- Expression and localization of Trypanosoma cruzi hsp60.
- Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi.
- Molecular cloning and characterization of the 78-kilodalton glucose-regulated protein of Trypanosoma cruzi.
- Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice.
- A mitochondrial heat shock protein from Crithidia fasciculata.
- Homologues of the 24-kDa flagellar Ca(2+)-binding protein gene of Trypanosoma cruzi are present in other members of the Trypanosomatidae family.
- Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins.
- The DnaJ family of protein chaperones in Trypanosoma cruzi.
- TcDJ1, a putative mitochondrial DnaJ protein in Trypanosoma cruzi.
- Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism.
- Identification of calcium binding sites in the trypanosome flagellar calcium-acyl switch protein.
- Flagellar elongation induced by glucose limitation is preadaptive for Trypanosoma cruzi differentiation.
- Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance.
- The life cycle of Trypanosoma cruzi revisited.
- Autoimmunity in Chagas heart disease.
- Cardiac myosin autoimmunity in acute Chagas' heart disease.
Schools
University of Ia Roy J amp L Carver Com
Doctors Specialties
- Molecular Genetic Pathology
- Pathology
Accepted Insurances
- Great West Healthcare-Cigna PPO
- First Health (Coventry Health Care) PPO
- Golden Rule
- Humana
- Medicare MCR
- Pipefitters
- Choice Plus POS
- Options PPO
- United Healthcare
Awards
- Fellow
- Member
- Amgen Outstanding Investigator
- Established Investigator
Education
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McGaw Medical Center of Northwestern University -
University of Iowa Carver College of Medicine
Hospital
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Northwestern Memorial Hospital -
Cedars-Sinai Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1891721098 |
| Last Name Of The Provider | ENGMAN |
| First Name Of The Provider | DAVID |
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