Assistant Professor, Psychiatry and Behavioral Science, Stony Brook University SOM
Psychiatry
Dr. David M. Margulies, MD
David Margulies practices Psychiatry. He attended Ross University School of Medicine. David M. Margulies, MD is a published doctor and has 67 publications published. The lastest was: 'Three-dimensional structure of H-2Dd complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120.'
Publications
- William E. Paul 1936-2015.
- The Structure of Mouse Cytomegalovirus m04 Protein Obtained from Sparse NMR Data Reveals a Conserved Fold of the m02-m06 Viral Immune Modulator Family.
- CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition.
- A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules.
- Bidentate ligation of heme analogues; novel biomimetics of peroxidase active site.
- A "chimeric" C57l-derived Ly49 inhibitory receptor resembling the Ly49D activation receptor.
- Surface binding inhibitors of the SCF-KIT protein-protein interaction.
- Interactions of TCRs with MHC-peptide complexes: a quantitative basis for mechanistic models.
- Ly49A allelic variation and MHC class I specificity.
- TCR avidity: it's not how strong you make it, it's how you make it strong.
- The lectin-like NK cell receptor Ly-49A recognizes a carbohydrate-independent epitope on its MHC class I ligand.
- bca: an activation-related B-cell gene.
- Mapping the ligand of the NK inhibitory receptor Ly49A on living cells.
- Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog.
- Control of autoimmunity by regulatory T cells.
- Structural basis of MHC class I recognition by natural killer cell receptors.
- Two intermediate-avidity cytotoxic T lymphocyte clones with a disparity between functional avidity and MHC tetramer staining.
- Direct binding of the MHC class I molecule H-2Ld to CD8: interaction with the amino terminus of a mature cell surface protein.
- Antibodies directed against the MHC-I molecule H-2Dd complexed with an antigenic peptide: similarities to a T cell receptor with the same specificity.
- Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex.
- Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion.
- Three-dimensional structure of H-2Dd complexed with an immunodominant peptide from human immunodeficiency virus envelope glycoprotein 120.
- MHC class I molecules, structure and function.
- Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand.
- Interaction of the NK cell inhibitory receptor Ly49A with H-2Dd: identification of a site distinct from the TCR site.
- An allosteric mechanism Controls antigen presentation by the H-2K(b) complex.
- NK and CTL recognition of a single chain H-2Dd molecule: distinct sites of H-2Dd interact with NK and TCR.
- The X-ray crystal structure of a Valpha2.6Jalpha38 mouse T cell receptor domain at 2.5 A resolution: alternate modes of dimerization and crystal packing.
- Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.
- Rigidification of the alpha2 helix of an MHC class I molecule by a valine to proline mutation in position 165 does not prevent peptide-specific antigen presentation.
- Degenerate MHC restriction reveals the contribution of class I MHC molecules in determining the fine specificity of CTL recognition of an immunodominant determinant of...
- A three-domain T cell receptor is biologically active and specifically stains cell surface MHC/peptide complexes.
- A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity.
- Competitive inhibition in vivo and skewing of the T cell repertoire of antigen-specific CTL priming by an anti-peptide-MHC monoclonal antibody.
- Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells.
- Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.
- MHC class I recognition by Ly49 natural killer cell receptors.
- Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.
- How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance.
- Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.
- Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.
- Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.
- Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.
- Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution.
- A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens.
- Home schooling of NK cells.
- Availability of autoantigenic epitopes Controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.
- Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.
- Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay.
- The TLR3 signaling complex forms by cooperative receptor dimerization.
- Role of alpha3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs.
- Cellular expression and crystal structure of the murine cytomegalovirus Major histocompatibility complex class I-like glycoprotein, m153.
- Avidity of CD8 T cells sharpens immunodominance.
- Crystal structure of the murine cytomegalovirus MHC-I homolog m144.
- Backbone and side chain resonance assignmentsof a TRAV14-3 mouse T cell receptor domain.
- Monoclonal antibodies: producing magic bullets by somatic cell hybridization.
- Resistance to viral infection by intraepithelial lymphocytes in HIV-1 P18-I10-specific T-cell receptor transgenic mice.
- Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice.
- Molecular interactions: stiff or floppy (or somewhere in between?).
- Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).
- CD28, costimulator or agonist receptor?
- A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.
- Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide.
- Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.
- Binding of the natural killer cell inhibitory receptor Ly49A to its Major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-mic...
- Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.
Procedures Preformed
- Psychiatric Medication Therapy
Conditions Treated
- Adjustment Disorder
- Alcoholism (Alcohol Dependence)
- Anxiety
- Attention Deficit Hyperactivity Disorder (ADHD)
- View All
Doctors Specialties
- Psychiatry
Accepted Insurances
Education
-
SUNY Stony Brook University Hospital & Medical Center -
Ross University School of Medicine
Hospital
-
Stony Brook University Medical Center
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