Professor, Director of Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore and Professor, Pediatrics, Duke University School of Medicine
Research
Dr. David M. Virshup, MD
David Virshup is an expert in the field of Research. He attended Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a one of the best medicals schools. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. Doctor David M. Virshup, MD is also published. He has 98 publications published. The lastest publication: "Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method.'
Publications
- Wnt addiction of genetically defined cancers reversed by PORCN inhibition.
- Updating the Wnt pathways.
- B56-PP2A regulates motor dynamics for mitotic chromosome alignment.
- Sustained Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of protein phosphatase 2A-B56delta stabilizes its anti-apoptotic activity.
- Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
- Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.
- Disulfide Bond Requirements for Active Wnt Ligands.
- WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
- BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression.
- Unwinding the Wnt action of casein kinase 1.
- Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.
- Precise regulation of porcupine activity is required for physiological Wnt signaling.
- A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.
- PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.
- A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures.
- Cell biology. Enforcing the Greatwall in mitosis.
- Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.
- Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.
- Keeping the beat in the rising heat.
- From promiscuity to precision: protein phosphatases get a makeover.
- Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.
- Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.
- After hours keeps clock researchers CRYing Overtime.
- Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
- A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.
- Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
- Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.
- An opposite role for tau in circadian rhythms revealed by mathematical modeling.
- Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.
- Protein serine/threonine phosphatases: life, death, and sleeping.
- Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.
- Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
- Casein kinase I in the mammalian circadian clock.
- A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
- Regulation of casein kinase I epsilon activity by Wnt signaling.
- Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines.
- PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
- Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
- Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.
- The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas.
- B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.
- The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
- Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.
- Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells.
- Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.
- Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome.
- Initiation of SV40 DNA replication: mechanism and control.
- Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.
- Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.
- Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon.
- Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.
- Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.
- An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
- Casein kinase I: from obscurity to center stage.
- Casein kinase I: another cog in the circadian clockworks.
- Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.
- Nuclear export of mammalian PERIOD proteins.
- Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
- Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method.
- Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
- Lymphoblastic lymphoma and excessive toxicity from chemotherapy: an unusual presentation for Fanconi anemia.
- Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.
- Identification of casein kinase I substrates by in vitro expression cloning screening.
- Protein phosphatase 2A: a panoply of enzymes.
- Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro.
- Identification of a new family of protein phosphatase 2A regulatory subunits.
- Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.
- Occurrence of Henoch-Schönlein purpura in a child with Wilms' tumor.
- Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.
- T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.
- Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I.
- The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.
- Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle...
- Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis.
- Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.
- Focal encephalitis with enterovirus infections.
- DNA replication.
- Reconstitution of simian virus 40 DNA replication with purified proteins.
- Identification of cellular proteins required for simian virus 40 DNA replication.
- Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.
- Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.
- Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system?
- Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes.
- Cutaneous manifestations of Corynebacterium group JK sepsis.
- Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.
- Post-translational modifications regulate the ticking of the circadian clock.
- Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.
- Protein phosphatase 1 regulates the stability of the circadian protein PER2.
- Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.
- Reversible protein phosphorylation regulates circadian rhythms.
- Wnt signaling in development, disease and translational medicine.
- Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives.
- WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
- IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.
- Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.
- Casein kinase 1: Complexity in the family.
- Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.
Schools
Johns Hopkins University School of Medicine
Johns Hopkins Hospital
Doctors Specialties
- Research
Accepted Insurances
- Great West Healthcare-Cigna PPO
Education
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Johns Hopkins University -
Johns Hopkins University School of Medicine
Hospital
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Duke University Hospital
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