Physician
Family Medicine
Dr. David R. Howlett, MD
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Dr. David R. Howlett is an expert in the field of Family Medicine. He studied medicine at University of Connecticut School of Medicine. University of Connecticut School of Medicine is ranked 60 in research and 49 in primary care medicine He has 3 awards "Physician Practice Connections Recognition Program", "Patient-Centered Medical Home Recognition Program" and "Diabetes Recognition Program". David R. Howlett, MD has written publications. He has 44 publications published with PubMed. The lastest paper is: 'Fibrillogenesis of beta-amyloid.' He accepts Medicare.
Publications
- Synaptic protein expression is regulated by a pro-oxidant diet in APPxPS1 mice.
- Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.
- Pro-oxidant diet enhances beta/gamma secretase-mediated APP processing in APP/PS1 transgenic mice.
- Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
- Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.
- MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a tra...
- Imaging and spatial distribution of beta-amyloid peptide and metal ions in Alzheimer's plaques by laser ablation-inductively coupled plasma-mass spectrometry.
- Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.
- Age-related demethylation of mouse satellite DNA is easily detectable by HPLC but not by restriction endonucleases.
- Hemin and related porphyrins inhibit beta-amyloid aggregation.
- Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
- The effects of metal ions on the binding of a new alpha 2-adrenoceptor antagonist radioligand (3H)-RX 781094 in rat cerebral cortex.
- The radiology request form: a guide for the foundation year doctor.
- A technical note: pre-operative ultrasound-guided wire localization in head and neck surgery.
- Acute and chronic amphetamine treatments modulate striatal dopamine receptor binding sites.
- Potassium efflux enhancement by cromakalim (BRL 34915) in rabbit mesenteric artery: an indirect effect independent of calcium?
- Acute and chronic effects of a novel dihydrobenzofuran analogue and enalapril on blood pressure and plasma and tissue angiotensin converting enzyme activity in the sod...
- Antihypertensive and angiotensin converting enzyme inhibitory activities of a novel dihydrobenzofuran analogue.
- Specificity of action of the novel antihypertensive agent, BRL 34915, as a potassium channel activator. Comparison with nicorandil.
- Synthesis and antihypertensive activity of 4-(substituted-carbonylamino)-2H-1-benzopyrans.
- beta-Cyclodextrin interacts with the Alzheimer amyloid beta-A4 peptide.
- CRMP2 hyperphosphorylation is characteristic of Alzheimer''s disease and not a feature common to other neurodegenerative diseases.
- Characterisation of amyloid-induced inflammatory responses in the rat retina.
- APP transgenic mice and their application to drug discovery.
- Fibrillogenesis of beta-amyloid.
- Production of beta-amyloid by primary human foetal mixed brain cell cultures and its modulation by exogenous soluble beta-amyloid.
- Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans.
- Alzheimer's disease: correlation of the suppression of beta-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the prot...
- Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide.
- In search of an enzyme: the beta-secretase of Alzheimer''s disease is an aspartic proteinase.
- Computationally derived structural models of the beta-amyloid found in Alzheimer's disease plaques and the interaction with possible aggregation inhibitors.
- Ultrastructural and behavioural changes precede amyloid deposition in a transgenic model of Alzheimer's disease.
- Identification of a novel aspartic protease (Asp 2) as beta-secretase.
- The pathology of APP transgenic mice: a model of Alzheimer''s disease or simply overexpression of APP?
- Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide.
- Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation.
- Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer''s disease.
- Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
- Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
- ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
- Neurochemical changes in a double transgenic mouse model of Alzheimer''s disease fed a pro-oxidant diet.
- Longitudinal regional brain volume changes quantified in normal aging and Alzheimer''s APP x PS1 mice using MRI.
- Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Schools
University Of Connecticut School Of Medicine
Albany Memorial Hospital
University Conn Health Center
Doctors Specialties
- Family Medicine
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Pathway X Ind PPO Direct Access CT
- Assurant Health
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Connecticare HMO
- Connecticare POS
- EBS-RMSCO
- First Health (Coventry Health Care) PPO
- Golden Rule
- Harvard Pilgrim Health Care PPO
- Choice Care PPO
- Medicaid
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Freedom Plan
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- Oxford Liberty
- United Healthcare
Awards
- Physician Practice Connections Recognition Program
- Patient-Centered Medical Home Recognition Program
- Diabetes Recognition Program
Education
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University of Connecticut -
Albany Medical Center -
University of Connecticut School of Medicine
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