Associate Professor of Medicine, Massachusetts General Hospital
Internal Medicine
Dr. Denise L. Faustman, MD
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Denise Faustman is an expert in the field of Internal Medicine. He researched medicine at Washington University School of Medicine in St. Louis. Denise Faustman is a published doctor as well. He has 96 publications published. The latest was: Novel splicing of the human MHC-encoded peptide transporter confers unique properties.
Publications
- Treg activation defect in type 1 diabetes: correction with TNFR2 agonism.
- Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades.
- EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop?
- Proof-of-Concept, Randomized, Controlled Clinical Trial of Bacillus-Calmette-Guerin for Treatment of Long-Term Type 1 Diabetes.
- Novel automated blood separations validate whole cell biomarkers.
- Immunotherapy on trial for new-onset type 1 diabetes.
- Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism.
- Permanent reversal of diabetes in NOD mice.
- Reversal of type 1 diabetes in mice.
- A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response.
- Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.
- Regenerative medicine: Stem cell research turns to the spleen.
- Diabetes and stem cell researchers turn to the lowly spleen.
- Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice.
- Islet regeneration during the reversal of autoimmune diabetes in NOD mice.
- Impaired processing and presentation by MHC class II proteins in human diabetic cells.
- Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis.
- Role of defective apoptosis in type 1 diabetes and other autoimmune diseases.
- Reversal of established autoimmune diabetes by in situ beta-cell regeneration.
- Cells for repair: breakout session summary.
- Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice.
- TNF Receptor 2 and Disease: Autoimmunity and Regenerative Medicine.
- Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2.
- Antibodies for transplantation.
- Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans.
- The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases.
- The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis.
- Central role of defective apoptosis in autoimmunity.
- Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis.
- Reversal of established autoimmune diabetes by restoration of endogenous beta cell function.
- Implications of altered apoptosis in diabetes mellitus and autoimmune disease.
- Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets.
- Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression.
- Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody.
- Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants.
- Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2.
- Elimination of self-peptide major histocompatibility complex class I reactivity in NOD and beta 2-microglobulin-negative mice.
- Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes.
- Altered MHC class I expression: a role for transplantation and IDDM autoimmunity.
- Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells.
- Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis.
- Occult CD45 T cell developmental defect in type 1 diabetes.
- Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression.
- Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity.
- Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter.
- MHC class I and autoimmune diabetes.
- Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between pat...
- Gender is important: lessons in autoimmunity.
- Family cell lines available for research--an endangered resource?
- Strategies for circumventing transplant rejection: modification of cells, tissues and organs.
- Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens.
- Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis.
- Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group.
- New monoclonal antibody diagnostic reagents for type I diabetes: differential lymphocyte surface antigen expression related to disease.
- Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts.
- Expression of major histocompatibility complex antigens in cultures of clonally derived human myoblasts.
- Mechanisms of autoimmunity in type I diabetes.
- Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse.
- Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens.
- Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodies.
- Transplantation without immunosuppression.
- Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.
- Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.
- Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.
- Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.
- Abnormal T-lymphocyte subsets in type I diabetes.
- Analysis of T lymphocyte subsets in all stages of diabetes.
- T-lymphocyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects.
- Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.
- Prevention of xenograft rejection by masking donor HLA class I antigens.
- Faulty major histocompatibility complex class I function linked to autoimmune diabetes.
- Xenograft acceptance by masking donor antigens.
- A role for NF-kappaB and the proteasome in autoimmunity.
- The role of the proteasome in autoimmunity.
- Identification of premature ovarian failure patients with underlying autoimmunity.
- Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis.
- NOD mice are defective in proteasome production and activation of NF-kappaB.
- On the periphery: Nature questions the role of women in science.
- Novel splicing of the human MHC-encoded peptide transporter confers unique properties.
- Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes.
- Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation.
- Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes.
- Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes.
- Regenerative medicine: a radical reappraisal of the spleen.
- Search for cure moves forward despite controversy. Interview by Ho Spencer.
- Methods to characterize lymphoid apoptosis in a murine model of autoreactivity.
- Characterization of mouse spleen cells by subtractive proteomics.
- Reversal of Sjogren''s-like syndrome in non-obese diabetic mice.
- Stem cells in the spleen: therapeutic potential for Sjogren''s syndrome, type I diabetes, and other disorders.
- TNF receptor 2 pathway: drug target for autoimmune diseases.
- Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen.
- Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren''s syndrome.
- The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies.
- Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity.
- Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay.
Schools
Washington Center School of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
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Massachusetts General Hospital -
Washington University School of Medicine in St. Louis
Hospital
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Massachusetts General Hospital
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