Professor, Anesthesia and Perioperative Care, UCSF School of Medicine
Anesthesiology
Dr. Donald D. Koblin, MD
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Donald Koblin practices Anesthesiology. He researched medicine at University of Miami Miller School of Medicine. University of Miami Miller School of Medicine has a rank of 45 in research and a 0 in primary care Donald Koblin is a published doctor. He has 81 publications published. The most current publication "Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics)"
Publications
- The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene.
- Hypothesis: volatile anesthetics produce immobility by acting on two sites approximately five carbon atoms apart.
- Polyhalogenated methyl ethyl ethers: solubilities and anesthetic properties.
- Nonimmobilizers and transitional compounds may produce convulsions by two mechanisms.
- Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics)
- A molecular description of how noble gases and nitrogen bind to a model site of anesthetic action.
- Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration.
- The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunt...
- Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants.
- Dose-related biochemical markers of renal injury after sevoflurane versus desflurane anesthesia in volunteers.
- Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats.
- Minimum alveolar anesthetic concentration values for the enantiomers of isoflurane differ minimally.
- Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites.
- Convulsant activity of nonanesthetic gas combinations.
- Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers.
- Anesthetic and convulsant properties of aromatic compounds and cycloalkanes: implications for mechanisms of narcosis.
- Compound A: solubility in saline and olive oil; destruction by blood.
- Binding of halothane to serum albumin: relevance to theories of narcosis.
- Unitary versus multiple mechanisms of anesthesia.
- Anaesthetic properties of dimethylthiourea.
- Anesthesia by n-alkanes not consistent with the Meyer-Overton hypothesis: determinations of the solubilities of alkanes in saline and various lipids.
- Is there a cutoff in anesthetic potency for the normal alkanes?
- The Lazarus phenomenon re-revisited.
- Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis.
- Prolonged asystolic hyperkalemic cardiac arrest with no neurologic sequelae: the lazarus phenomenon arises again.
- Effects of halothane on the nicotinic acetylcholine receptor from Torpedo californica.
- Homocystinuria and administration of nitrous oxide.
- Molecular properties of the "ideal" inhaled anesthetic: studies of fluorinated methanes, ethanes, propanes, and butanes.
- A cutoff in potency exists in the perfluoroalkanes.
- Pharmacokinetics do not explain the absence of an anesthetic effect of perfluoropropane or perfluoropentane.
- Humans anesthetized with sevoflurane or isoflurane have similar arrhythmic response to epinephrine.
- Anaesthetic requirement in mice selectively bred for differences in ethanol sensitivity.
- Anesthetic requirement in the quaking mouse.
- Selective breeding alters murine resistance to nitrous oxide without alteration in synaptic membrane lipid composition.
- Mice tolerant to nitrous oxide are also tolerant to alcohol.
- Sensitivity to alcohol in mice with an altered brain fatty acid composition.
- Inactivation of methionine synthetase by nitrous oxide in mice.
- Nitrous oxide inactivates methionine synthetase in human liver.
- Cross-mating of mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia: potencies of nitrous oxide in offspring.
- Are convulsant gases also anesthetics?
- Anesthetic potencies and the unitary theory of narcosis.
- Dioxychlorane: a challenge to the correlation of anesthetic potency and lipid solubility.
- Mice tolerant to nitrous oxide are not tolerant to barbiturates.
- Withdrawal convulsions in mice following nitrous oxide.
- The lipid composition of human liver microsomes.
- Potencies of convulsant drugs in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia.
- Potencies of inhaled anesthetics and alcohol in mice selectively bred for resistance and susceptibility to nitrous oxide anesthesia.
- Age-dependent alterations in nitrous oxide requirement of mice.
- Minimum alveolar concentrations and oil/gas partition coefficients of four anesthetic isomers.
- Potencies of barbiturates in mice selectively bred for resistance or susceptibility to nitrous oxide anesthesia.
- Brain monoamines and the high pressure neurological syndrome.
- Chronic exposure to inhaled anesthetics increases cholesterol content in Acholeplasma laidlawii.
- Alteration of synaptic membrane fatty acid composition and anesthetic requirement.
- Cortisol following etomidate administration: should we give it the time of day?
- Is nitrous oxide a dangerous anesthetic for vitamin B12-deficient subjects?
- Craniotomy for tumor in a patient with a bronchopleural fistula: anesthetic considerations.
- Anesthetic management of the parturient receiving amiodarone.
- I-653 resists degradation in rats.
- Mechanism of age-related and nitrous oxide-associated anesthetic sensitivity: the role of brain catecholamines.
- Metabolism of I-653 and isoflurane in swine.
- Metabolism of isoflurane in patients receiving isoniazid.
- Halogenation and anesthetic potency.
- Methionine synthase activities in mice following acute exposures to ethanol and nitrous oxide.
- Nitrous oxide interferes with the aminopyrine breath test.
- Disruption of folate and vitamin B12 metabolism in aged rats following exposure to nitrous oxide.
- Biotransformation and hepato-renal function in volunteers after exposure to desflurane (I-653).
- Hematologic effects of nitrous oxide in surgical patients.
- Effect of nitrous oxide on folate and vitamin B12 metabolism in patients.
- Nitrous oxide: a cause of cancer or chemotherapeutic adjuvant?
- Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice.
- What solvent best represents the site of action of inhaled anesthetics in humans, rats, and dogs?
- Vitamin B12 and folate status in rats after chronic administration of ethanol and acute exposure to nitrous oxide.
- Fluoride metabolites after prolonged exposure of volunteers and patients to desflurane.
- Saturable binding of anesthetics to nicotinic acetylcholine receptors. A possible mechanism of anesthetic action.
- Aging, chronic administration of ethanol, and acute exposure to nitrous oxide: effects on vitamin B12 and folate status in rats.
- Characteristics and implications of desflurane metabolism and toxicity.
- Voltage-dependent and voltage-independent blockade of acetylcholine receptors by local anesthetics in Electrophorus electroplaques.
- Current concepts: theories of narcosis.
- Tolerance of mice to nitrous oxide.
- Urethane: help or hindrance?
Schools
University of Miami School of Medicine
Penn St University Hp M S Hershey Mc
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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Penn State University -
University of Miami Miller School of Medicine
Hospital
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UCSF Medical Center -
San Francisco VA Medical Center
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