Department of Anesthesia, Critical Care, and Pain Medicine
Anesthesiology
Dr. Douglas E. Raines, MD
|
|
Give Review
Dr. Douglas E. Raines works in the field of Anesthesiology. He attended University of Virginia School of Medicine. Douglas E. Raines, MD is a published physician. He published 78 publications, including: 'Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor.' He accepts Medicare.
Publications
- γ-Aminobutyric Acid Type A Receptor Modulation by Etomidate Analogs.
- Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
- Advancing Novel Anesthetics: Pharmacodynamic and Pharmacokinetic Studies of Cyclopropyl-methoxycarbonyl Metomidate in Dogs.
- Total Intravenous Anesthesia Using N-Methyl-D-Aspartate (NMDA) Receptor-Sparing Drugs in a Patient with Anti-NMDA Receptor Encephalitis.
- Analogues of Etomidate: Modifications around Etomidate's Chiral Carbon and the Impact on In Vitro and In Vivo Pharmacology.
- The pharmacology of cyclopropyl-methoxycarbonyl metomidate: a comparison with propofol.
- Carboetomidate: An Analog of Etomidate That Interacts Weakly with 11?-Hydroxylase.
- The Pyrrole Etomidate Analog Carboetomidate Potently Inhibits Human 5-HT3A Receptor Function: Comparisons with Etomidate and Potential Implications for Emetogenesis.
- Adrenocortical suppression and recovery after continuous hypnotic infusion: etomidate versus its soft analogue cyclopropyl-methoxycarbonyl metomidate.
- Modifying Methoxycarbonyl Etomidate Inter-Ester Spacer Optimizes In Vitro Metabolic Stability and In Vivo Hypnotic Potency and Duration of Action.
- Electroencephalographic and Hypnotic Recoveries following Brief and Prolonged Infusions of Etomidate and Optimized Soft Etomidate Analogs.
- Allyl m-Trifluoromethyldiazirine Mephobarbital: An Unusually Potent Enantioselective and Photoreactive Barbiturate General Anesthetic.
- Carboetomidate Inhibits Alpha4/Beta2 Neuronal Nicotinic Acetylcholine Receptors at Concentrations Affecting Animals.
- Electroencephalographic Recovery, Hypnotic Emergence, and the Effects of Metabolite after Continuous Infusions of a Rapidly Metabolized Etomidate Analog in Rats.
- p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of Propofol.
- Pharmacological Studies of Methoxycarbonyl Etomidate's Carboxylic Acid Metabolite.
- In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate.
- Differential effects of etomidate and its pyrrole analogue carboetomidate on the adrenocortical and cytokine responses to endotoxemia.
- Closed-loop Continuous Infusions of Etomidate and Etomidate Analogs in Rats: A Comparative Study of Dosing and the Impact on Adrenocortical Function.
- p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.
- Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function.
- Inhibition of human alpha4beta2 neuronal nicotinic acetylcholine receptors by volatile aromatic anesthetics depends on drug hydrophobicity.
- Methoxycarbonyl-etomidate: a novel rapidly metabolized and ultra-short-acting etomidate analogue that does not produce prolonged adrenocortical suppression.
- A comparison of the molecular bases for N-methyl-D-aspartate-receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.
- Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
- Increases in spinal cerebrospinal fluid potassium concentration do not increase isoflurane minimum alveolar concentration in rats.
- Differential effects of serotonin and dopamine on human 5-HT3A receptor kinetics: interpretation within an allosteric kinetic model.
- Volatile aromatic anesthetics variably impact human gamma-aminobutyric acid type A receptor function.
- Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols.
- Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility.
- Automated documentation error detection and notification improves anesthesia billing performance.
- Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on...
- Contrasting roles of the N-methyl-D-aspartate receptor in the production of immobilization by conventional and aromatic anesthetics.
- Differential modulation of human N-methyl-D-aspartate receptors by structurally diverse general anesthetics.
- Do N-methyl-D-aspartate receptors mediate the capacity of inhaled anesthetics to suppress the temporal summation that contributes to minimum alveolar concentration?
- Kinetics of anesthetic-induced conformational transitions in a four-alpha-helix bundle protein.
- General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition.
- Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols.
- Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors.
- Anesthetic management for transurethral resection of the bladder in a 74-year-old man with uncorrected tetralogy of Fallot.
- The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.
- Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
- Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration.
- Modulation of GABA(A) receptor function by nonhalogenated alkane anesthetics: the effects on agonist enhancement, direct activation, and inhibition.
- Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.
- Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
- The role of electrostatic interactions in governing anesthetic action on the torpedo nicotinic acetylcholine receptor.
- Anesthetic drug development: Novel drugs and new approaches.
- Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.
- The enhancement of proton/hydroxyl flow across lipid vesicles by inhalation anesthetics.
- Photosensitivity and perioperative polyneuropathy complicating orthotopic liver transplantation in a patient with erythropoietic protoporphyria.
- Artifactual hypertension due to transducer cable malfunction.
- Aprotinin administration and pulmonary thromboembolism during orthotopic liver transplantation: report of two cases.
- Time-dependent binding of paramagnetic and fluorescent hydrophobic ions to the acetylcholine receptor from Torpedo.
- Anesthetic management and outcome following noncardiac surgery in nonparturients with Eisenmenger's physiology.
- Perturbation of lipid and protein structure by general anesthetics: how little is too little?
- Anesthetic cutoff in cycloalkanemethanols. A test of current theories.
- Transient low-affinity agonist binding to Torpedo postsynaptic membranes resolved by using sequential mixing stopped-flow fluorescence spectroscopy.
- Agonist binding and affinity state transitions in reconstituted nicotinic acetylcholine receptors revealed by single and sequential mixing stopped-flow fluorescence sp...
- Conformational transitions of the nicotinic acetylcholine receptor as a model for anesthetic actions on ligand-gated ion channels: single and sequential mixing stopped...
- On the importance of volatile agents devoid of anesthetic action.
- Halothane interactions with nicotinic acetylcholine receptor membranes. Steady-state and kinetic studies of intrinsic fluorescence quenching.
- Anesthetic and nonanesthetic halogenated volatile compounds have dissimilar activities on nicotinic acetylcholine receptor desensitization kinetics.
- Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol.
- The effect of general anesthetics on the dynamics of phosphatidylcholine-acetylcholine receptor interactions in reconstituted vesicles.
- Electron spin resonance studies of acyl chain motion in reconstituted nicotinic acetylcholine receptor membranes.
- The role of charge in lipid selectivity for the nicotinic acetylcholine receptor.
- The alkyl chain dependence of the effect of normal alcohols on agonist-induced nicotinic acetylcholine receptor desensitization kinetics.
- Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor.
- Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant.
- General anesthetics modify the kinetics of nicotinic acetylcholine receptor desensitization at clinically relevant concentrations.
- Nonhalogenated alkane anesthetics fail to potentiate agonist actions on two ligand-gated ion channels.
- Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.
- Nonanesthetic volatile drugs obey the Meyer-Overton correlation in two molecular protein site models.
- A hydrophobic inhibitor of the nicotinic acetylcholine receptor acts on the resting state.
- Inhibition of human 5-HT(3A) and 5-HT(3AB) receptors by etomidate, propofol and pentobarbital.
- Distinct Hypnotic Recoveries After Infusions of Methoxycarbonyl Etomidate and Cyclopropyl Methoxycarbonyl Metomidate: The Role of the Metabolite.
Schools
University Of Virginia School Of Medicine
Albany Medical Center
Massachusetts General Hospital
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
-
Massachusetts General Hospital -
Albany Medical Center -
University of Virginia School of Medicine
Hospital
-
Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1013907542 |
| Last Name Of The Provider | RAINES |
| First Name Of The Provider | DOUGLAS |
| View All |
Similar Doctors
|
|
Dr. Eric T. Pierce, MD
 This Doctor is OpenDoctor Recommended.
|
|
|
Dr. George E. Battit, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Julianne Bacsik, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Feroze-Ud-Din Mahmood, MB
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Rebecca J. Spencer, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Samuel T. Rodriguez, MD |
|
|
Dr. Raymond S. Park, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Mohammed T. Hanifi, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Ann H. Bui, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Brian M. Osman, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Christine N. Sang, MD
This Doctor is OpenDoctor Recommended.
|
|
|
Dr. Michelle C. Carley, MD
This Doctor is OpenDoctor Recommended.
|