Physician
Hematology
Dr. Douglas M. Tollefsen, MD
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Douglas Tollefsen practices Hematology. He went to medical school at Washington University School of Medicine in St. Louis. He received 1 awards: "Elected Member". Douglas Tollefsen has written publications. He has 88 publications published with PubMed. The lastest paper is: 'Anticoagulant and antithrombotic activity of maltodapoh, a novel sulfated tetrasaccharide.' He accepts Medicare.
Publications
- Thrombin-inhibiting nanoparticles rapidly constitute versatile and detectable anticlotting surfaces.
- Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial Thrombosis.
- Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II.
- Dermatan sulfate and bone marrow mononuclear Cells used as a new therapeutic strategy after arterial injury in mice.
- Glycosaminoglycan-binding properties and kinetic characterization of human heparin cofactor II expressed in Escherichia coli.
- A self-inactivating gamma-retroviral vector reduces manifestations of mucopolysaccharidosis I in mice.
- Mice lacking the extraCellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury.
- Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II.
- Accelerated atherogenesis and neointima formation in heparin cofactor II deficient mice.
- Heparin cofactor II modulates the response to vascular injury.
- Placental dermatan sulfate: isolation, anticoagulant activity, and association with heparin cofactor II.
- Heparin cofactor II levels do not predict the development of coronary heart Disease: the Atherosclerosis Risk in Communities (ARIC) study.
- Fusion proteins comprising annexin V and Kunitz protease inhibitors are highly potent thrombogenic site-directed anticoagulants.
- Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice.
- Does heparin cofactor II modulate atherosclerosis and restenosis?
- The contributions of the alpha 2 beta 1 integrin to vascular Thrombosis in vivo.
- Heparin cofactor II deficiency.
- Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II.
- Heparin cofactor II inhibits arterial Thrombosis after endothelial injury.
- α2β1 Integrin, GPVI Receptor, and Common FcRγ Chain on Mouse Platelets Mediate Distinct Responses to Collagen in Models of Thrombosis.
- Development of the human Coagulation system in the healthy premature infant.
- Inhibition of human platelet aggregation by monovalent antifibrinogen antibody fragments.
- Induction of the platelet release reaction by phytohemagglutinin.
- Specific glycosaminoglycans support the inhibition of thrombin by plasminogen activator inhibitor 1.
- Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex.
- Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder.
- Development of the human Coagulation system in the full-term infant.
- Detection of a new heparin-dependent inhibitor of thrombin in human plasma.
- Evidence for a single class of thrombin-binding sites of human platelets.
- Isolation and characterization of a partial cDNA clone for heparin cofactor II1.
- Binding of the products of prothrombin activation to human platelets.
- The presence of methionine or threonine at position 381 in vitronectin is correlated with proteolytic cleavage at arginine 379.
- Complete nucleotide sequence of the gene for human heparin cofactor II and mapping to chromosomal band 22q11.
- Biosynthesis of functionally active heparin cofactor II by a human hepatoma-derived Cell line.
- Amino acid residues of heparin cofactor II required for stimulation of thrombin inhibition by sulphated polyanions.
- Thrombin-inhibiting perfluorocarbon nanoparticles provide a novel strategy for the treatment and magnetic resonance imaging of acute Thrombosis.
- Activation of heparin cofactor II by heparin and dermatan sulfate.
- Cyclic AMP-dependent protein kinase phosphorylates serine378 in vitronectin.
- The binding of human and bovine thrombin to human platelets.
- The protease specificity of heparin cofactor II. Inhibition of thrombin generated during Coagulation.
- The binding of thrombin to the surface of human platelets.
- Identification of two sites of sulfation of human heparin cofactor II.
- Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.
- Heparin cofactor II activity in patients with disseminated intravascular Coagulation and hepatic failure.
- N-desulfated/acetylated heparin ameliorates the progression of renal Disease in rats with subtotal renal ablation.
- Modulation of heparin cofactor II activity by histidine-rich glycoprotein and platelet factor 4.
- Murine heparin cofactor II: purification, cDNA sequence, expression, and gene structure.
- Laboratory diagnosis of antithrombin and heparin cofactor II deficiency.
- Anticoagulant and antithrombotic activity of maltodapoh, a novel sulfated tetrasaccharide.
- Effect of low molecular weight heparin preparations on the inhibition of thrombin by heparin cofactor II.
- Phosphorylation of vitronectin by a protein kinase in human plasma. Identification of a unique phosphorylation site in the heparin-binding domain.
- COX-1(+/-)COX-2(-/-) genotype in mice is associated with shortened time to carotid artery occlusion through increased PAI-1.
- Structure of a dermatan sulfate hexasaccharide that binds to heparin cofactor II with high affinity.
- Role of lysine 173 in heparin binding to heparin cofactor II.
- Activation of heparin cofactor II by fibroblasts and vascular smooth muscle Cells.
- Heparin cofactor II.
- Insight into the mechanism of action of heparin cofactor II.
- Activation of heparin cofactor II by heparin oligosaccharides.
- Isolation of frog and chicken cDNAs encoding heparin cofactor II.
- Ligand binding to thrombin exosite II induces dissociation of the thrombin-heparin cofactor II(L444R) complex.
- Heparin cofactor II: cDNA sequence, chromosome localization, restriction fragment length polymorphism, and expression in Escherichia coli.
- Activation of heparin cofactor II by dermatan sulfate.
- Molecular size of dermatan sulfate oligosaccharides required to bind and activate heparin cofactor II.
- Molecular interactions between heparin cofactor II and thrombin.
- The interaction of glycosaminoglycans with heparin cofactor II.
- Heparin cofactor II activation by dermatan sulfate.
- The interaction of glycosaminoglycans with heparin cofactor II: structure and activity of a high-affinity dermatan sulfate hexasaccharide.
- Cross-competition for binding of alpha 1-antitrypsin (alpha 1 AT)-elastase complexes to the serpin-enzyme complex receptor by other serpin-enzyme complexes and by prot...
- Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II.
- Inhibition of meizothrombin and meizothrombin(desF1) by heparin cofactor II.
- The N-terminal acidic domain of heparin cofactor II mediates the inhibition of alpha-thrombin in the presence of glycosaminoglycans.
- Antithrombin activity of a peptide corresponding to residues 54-75 of heparin cofactor II.
- Assessment of interference by heparin cofactor II in the DuPont aca antithrombin-III assay.
- Allosteric effects of a monoclonal antibody against thrombin exosite II.
- Substitution of arginine for Leu444 in the reactive site of heparin cofactor II enhances the rate of thrombin inhibition.
- Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm. Sulfated fucose branches on the polysaccharide account for its high anticoag...
- Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans.
- Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines hep...
- Heparin cofactor IIOslo. Mutation of Arg-189 to His decreases the affinity for dermatan sulfate.
- Site-directed mutagenesis of arginine 103 and lysine 185 in the proposed glycosaminoglycan-binding site of heparin cofactor II.
- Anticoagulant activities of a monoclonal antibody that binds to exosite II of thrombin.
- Role of the proposed serpin-enzyme complex receptor recognition site in binding and internalization of thrombin-heparin cofactor II complexes by hepatocytes.
- Highly sulfated dermatan sulfates from Ascidians. Structure versus anticoagulant activity of these glycosaminoglycans.
- A unique dermatan sulfate-like glycosaminoglycan from ascidian. Its structure and the effect of its unusual sulfation pattern on anticoagulant activity.
- Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, prepara...
- N-Acetylgalactosamine 4,6-O-sulfate residues mediate binding and activation of heparin cofactor II by porcine mucosal dermatan sulfate.
- Vascular dermatan sulfate and heparin cofactor II.
Schools
Washington Center School of Medicine
University Of Co School Of Med
Procedures Preformed
- Plasmapheresis
Conditions Treated
- Anemia
- Coagulation Disorders (incl. Hemophilia)
- Deep Vein Thrombosis (DVT)
- Immune Thrombocytopenic Purpura (ITP)
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Doctors Specialties
- Hematology
Accepted Insurances
Awards
- Elected Member
Education
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University of Colorado -
Washington University School of Medicine in St. Louis
Hospital
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Barnes-Jewish Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1679599815 |
| Last Name Of The Provider | TOLLEFSEN |
| First Name Of The Provider | DOUGLAS |
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