Senior Vice President, Clinical, Medical and Regulatory Affairs and Chief Medical Officer, Caladrius Biosciences, Inc. Adjunct Professor in Medicine-Cardiology, Northwestern University Medical School Clinical Professor of Medicine, NYU Langone Medica
Cardiology
Dr. Douglas W. Losordo, MD
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Dr. Douglas W. Losordo practices Cardiology. He graduated from University of Vermont College of Medicine. He received awards:"Fellow (FACC)" and "Super Doctor". Douglas Losordo is a published doctor as well. He has 101 publications published. The latest was: A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic heart.
Publications
- A critical role of Src family kinase in SDF-1/CXCR4-mediated bone-marrow progenitor cell recruitment to the ischemic Heart.
- E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression.
- Genetic deletion of TNFR2 augments inflammatory response and blunts satellite-cell-mediated recovery response in a hind limb ischemia model.
- Enhanced potency of cell-based therapy for ischemic tissue repair using an injectable bioactive epitope presenting nanofiber support matrix.
- Going Mobile: Enhanced Recovery From Myocardial Infarction via Stem Cell Mobilization and Homing for Tissue Repair.
- Exosomes and cardiac repair after Myocardial infarction.
- Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis.
- Topical application of ex vivo expanded endothelial progenitor cells promotes vascularisation and wound healing in diabetic mice.
- Endothelial dysfunction and systemic Hypertension by selective cGMP-dependent protein kinase I inhibition using novel cell-penetrating peptide delivered in vivo.
- Progenitor Cell Release Plus Exercise To Improve Functional Performance In Peripheral Artery Disease: The Propel Study.
- A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intraMyocardial autologous CD34+ cell a...
- Cell therapy of peripheral arterial Disease: from experimental findings to clinical trials.
- An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic Heart fail...
- CXC-chemokine receptor 4 antagonist AMD3100 promotes cardiac functional recovery after ischemia/reperfusion injury via endothelial nitric oxide synthase-dependent mech...
- Estradiol promotes neural stem cell differentiation into endothelial lineage and angiogenesis in injured peripheral nerve.
- Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth.
- CXCR4 Antagonist AMD3100 Accelerates Impaired Wound Healing in Diabetic Mice.
- Prevention and recovery of hibernating myocardium by microvascular repair.
- Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair.
- Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity.
- Sonic Hedgehog-Induced Functional Recovery After Myocardial Infarction Is Enhanced by AMD3100-Mediated Progenitor-Cell Mobilization.
- Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia.
- Cell therapy for critical limb ischemia: moving forward one step at a time.
- CD34-Positive Stem Cells in the Treatment of Heart and Vascular Disease in Human Beings.
- Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium.
- CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity.
- Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart Disease.
- Myocardial knockdown of mRNA-stabilizing protein HuR attenuates post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice.
- CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after Myocardial infarction.
- Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation.
- Challenges in the translation of cardiovascular cell therapy.
- Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice.
- Right Atrial Merkel cell carcinoma metastasis.
- Career moves: induced pluripotent cells from human Aortic smooth muscle cells can efficiently redifferentiate into parental phenotype.
- The Hedgehog transcription factor Gli3 modulates angiogenesis.
- Human studies of angiogenic gene therapy.
- Regulation of vascular contractility and blood pressure by the E2F2 transcription factor.
- Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of Myocardial infarction by inducing CXCR4 expression.
- The relative potency and safety of endothelial progenitor cells and unselected mononuclear cells for recovery from Myocardial infarction and ischemia.
- IL-10 inhibits inflammation and attenuates left ventricular remodeling after Myocardial infarction via activation of STAT3 and suppression of HuR.
- A big promise from the very small identification of circulating embryonic stem-like pluripotent cells in patients with Acute myocardial infarction.
- Bioengineering to enhance progenitor cell therapeutics.
- Therapeutic angiogenesis for critical limb ischemia: microvascular therapies coming of age.
- Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair.
- Endothelial progenitor cells for cardiovascular regeneration.
- Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle.
- Frontiers in nephrology: the evolving therapeutic applications of endothelial progenitor cells.
- STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted m...
- Hypoxia up-regulates the angiogenic cytokine secretoneurin via an HIF-1alpha- and basic FGF-dependent pathway in muscle cells.
- Therapeutic Myocardial angiogenesis.
- Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice.
- Intramyocardial transplantation of autologous CD34+ stem cells for intractable Angina: a phase I/IIa double-blind, randomized controlled trial.
- Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing.
- The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.
- Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization.
- Critical role of endothelial Notch1 signaling in postnatal angiogenesis.
- Statins and the endothelium.
- Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
- Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after Myocardial infarction.
- CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after Myocardial infarction compared with total mononuclear cells.
- IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.
- Netrins promote developmental and therapeutic angiogenesis.
- Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.
- Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling.
- Estradiol enhances recovery after Myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced ...
- Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury.
- Cell therapy for Acute myocardial infarction: curb your enthusiasm?
- Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization.
- Atherosclerosis 2005: recent discoveries and novel hypotheses.
- Sonic hedgehog Myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling.
- Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages.
- Double face of VEGF.
- Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy.
- The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.
- Repair of ischemic heart Disease with novel bone marrow-derived multipotent stem cells.
- Ethanol modulation of TNF-alpha biosynthesis and signaling in endothelial cells: synergistic augmentation of TNF-alpha mediated endothelial cell dysfunctions by chroni...
- Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting ...
- Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization.
- Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic Cardiomyopathy: restoration of microvascular homeost...
- Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide syntha...
- Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after Myocardial infarction.
- Long-term (2-year) clinical events following transthoracic intraMyocardial gene transfer of VEGF-2 in no-option patients.
- Non-viral vectors for gene therapy: clinical trials in cardiovascular Disease.
- Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy.
- Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves.
- Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in Myocardial ischemia.
- Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.
- Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.
- Unexpected severe calcification after transplantation of bone marrow cells in Acute myocardial infarction.
- Therapeutic angiogenesis and vasculogenesis for ischemic Disease: part II: cell-based therapies.
- Therapeutic angiogenesis and vasculogenesis for ischemic Disease. Part I: angiogenic cytokines.
- The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo.
- Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization aft...
- Transplant graft vasculopathy: a dark side of bone marrow stem cells?
- Tumor necrosis factor-mediated E2F1 suppression in endothelial cells: differential requirement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase sign...
- One-year follow-up of direct Myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-opt...
- Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.
- Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endotheli...
- All in the family: VEGF-B joins the ranks of proangiogenic cytokines.
- Endothelial recovery: the next target in restenosis prevention.
Schools
University Of Vermont College Of Medicine
St Elizabeths Hospital
Procedures Preformed
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Coronary Angioplasty, Atherectomy and Stent
- Peripheral Artery Catheterization
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
- View All
Doctors Specialties
- Cardiology
- Interventional Cardiology
Accepted Insurances
Awards
- Fellow (FACC)
- Super Doctor
Education
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St Elizabeth's Medical Center -
University of Vermont College of Medicine
Hospital
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Northwestern Memorial Hospital -
NYU Langone Medical Center
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