Physician
Internal Medicine
Dr. Edward J. Pearce II, MD
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Edward J. Pearce II practices Internal Medicine. He researched medicine at Baylor College of Medicine. Edward Pearce is also published. He has 101 publications published. The lastest publication: "Evidence of a T helper type 2 activation in human schistosomiasis.'
Publications
- IL-4-Secreting Secondary T Follicular Helper (Tfh) Cells Arise from Memory T Cells, Not Persisting Tfh Cells, through a B Cell-Dependent Mechanism.
- Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization.
- Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
- For macrophages, ndufs is enough.
- Mechanistic target of rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function.
- Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis.
- Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival.
- Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.
- Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter.
- TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
- Regulation of the Development of the Hepatic B Cell Compartment during Schistosoma mansoni Infection.
- CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability.
- Imaging trematode and nematode parasites.
- Posttranscriptional control of T cell effector function by aerobic glycolysis.
- Special issue: Translatability of helminth therapy.
- Th2 responses in schistosomiasis.
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8(+) T Cell Memory Development.
- Transgenesis in the parasitic nematode Strongyloides ratti.
- Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
- Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover.
- Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
- Regulation of pathogenesis and immunity in helminth infections.
- MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
- T follicular helper cells differentiate from Th2 cells in response to helminth antigens.
- Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.
- Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression.
- Uncoupling of induced protein processing from maturation in dendritic cells exposed to a highly antigenic preparation from a helminth parasite.
- Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88.
- Cutting edge: Helminth infection induces IgE in the absence of mu- or delta-chain expression.
- Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendriti...
- Th2 differentiation is unaffected by Jagged2 expression on dendritic cells.
- Helminth infections: the great neglected tropical diseases.
- Suppression of Th2 cell development by Notch ligands Delta1 and Delta4.
- Worms tame mast cells.
- piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni.
- Memory CD4 T cells enhance primary CD8 T-cell responses.
- Cutting edge: IPSE/alpha-1, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo.
- Th1 and Th2 cells help CD8 T-cell responses.
- Functional plasticity in memory T helper cell responses.
- TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni.
- IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.
- Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells.
- Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population.
- Dendritic cell-intrinsic expression of NF-kappa B1 is required to promote optimal Th2 cell differentiation.
- TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development.
- Helminth antigens modulate TLR-initiated dendritic cell activation.
- Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii.
- CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
- Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments,...
- An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.
- CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses.
- Lack of C3 affects Th2 response development and the sequelae of chemotherapy in schistosomiasis.
- Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction.
- Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cells.
- Immunology of parasitic helminth infections.
- Eukaryotic initiation factor 2 alpha subunit associates with TGF beta receptors and 14-3-3 epsilon and acts as a modulator of the TGF beta response.
- Cutting edge: Th2 response induction by dendritic cells: a role for CD40.
- Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasis.
- Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni.
- Schistosome vaccines: current progress and future prospects.
- Strategies for induction of protective immunity against schistosomes.
- Mechanisms of immune evasion in schistosomiasis.
- Schistosomiasis. Proselytizing with immunity.
- Schistosomiasis vaccine.
- Immunization against parasites: bridging the gap between attenuated and non-living vaccines.
- Metabolic Control of Dendritic Cell Activation and Function: Recent Advances and Clinical Implications.
- Transposon-mediated chromosomal integration of transgenes in the parasitic nematode Strongyloides ratti and establishment of stable transgenic lines.
- Cell Death and Reproductive Regression in Female Schistosoma mansoni.
- Growth factors and chemotactic factors from parasitic helminths: molecular evidence for roles in host-parasite interactions versus parasite development.
- A bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni.
- Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function.
- Host-pathogen interactions: pas de deux.
- Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expression.
- Genetic manipulation of schistosomes.
- Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo.
- Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth.
- Tegumental expression of a novel type II receptor serine/threonine kinase (SmRK2) in Schistosoma mansoni.
- Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune response.
- Th2 response polarization during infection with the helminth parasite Schistosoma mansoni.
- Transgene expression in Schistosoma mansoni: introduction of RNA into schistosomula by electroporation.
- Progress towards a vaccine for schistosomiasis.
- 14-3-3 proteins in Schistosoma mansoni; identification of a second epsilon isoform.
- The immunobiology of schistosomiasis.
- Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages.
- Transforming growth factor-beta and insulin-like signalling pathways in parasitic helminths.
- Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii.
- SIP, a novel SH3 domain-containing protein, interacts with Schistosoma mansoni receptor kinase 1.
- Human transforming growth factor-beta activates a receptor serine/threonine kinase from the intravascular parasite Schistosoma mansoni.
- CD8- dendritic cell activation status plays an integral role in influencing Th2 response development.
- Role of IL-6 in directing the initial immune response to schistosome eggs.
- Functional conservation of Schistosoma mansoni Smads in TGF-beta signaling.
- Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent.
- IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis.
- Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice.
- Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni.
- Evidence of a T helper type 2 activation in human schistosomiasis.
- IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni.
- The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses.
- Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF-alpha and early death in C57BL/6 mice.
- Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection.
Schools
Baylor University
Westland Med Center
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
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Baylor College of Medicine
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