Professor of Medicine, Brigham and Women's Hospital
Cardiology
Dr. Elazer R. Edelman, MD
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Elazer Edelman practices Cardiology. He went to medical school at Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He has 2 awards "Elected Member" and "Fellow (FACC)". Elazer Edelman is a published doctor and has 103 publications published. The lastest was: 'Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment.' Elazer R. Edelman, MD accepts Medicare payments and is registered with Medicare.gov.
Publications
- Coronary Artery Disease and Diabetes Mellitus.
- Tracking of Drug Release and Material Fate for Naturally Derived Omega-3 Fatty Acid Biomaterials.
- Cell-Substrate Interactions: Tuning of Collagen Scaffold Properties Modulates Embedded Endothelial Cell Regulatory Phenotype in Repair of Vascular Injuries In Vivo (Ad...
- Dabigatran and rivaroxaban use in Atrial fibrillation patients on hemodialysis.
- miRNAs in atherosclerotic plaque initiation, progression, and rupture.
- Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep.
- Particulates from hydrophilic-coated guiding sheaths embolise to the brain.
- Enhancing physiologic simulations using supervised learning on coarse mesh solutions.
- Vascular Dilation, Tachycardia, and Increased Inotropy Occur Sequentially with Increasing Epinephrine Dose Rate, Plasma and Myocardial Concentrations, and cAMP.
- Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia.
- How Do We Prevent the Vulnerable Atherosclerotic Plaque From Rupturing? Insights From In Vivo Assessments of Plaque, Vascular Remodeling, and Local Endothelial Shear S...
- Acute rejection in vascularized composite allotransplantation.
- Methodological Standardization for the Pre-Clinical Evaluation of Renal Sympathetic Denervation.
- Innervation patterns may limit response to endovascular renal denervation.
- Myocardial drug distribution generated from local epicardial application: Potential impact of cardiac capillary perfusion in a swine model using epinephrine.
- Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics?
- Extent of flow recirculation governs expression of atherosclerotic and thrombotic biomarkers in arterial bifurcations.
- Endothelial insights: the florian dialectic.
- Use of Pressure-volume Conductance Catheters in Real-time Cardiovascular Experimentation.
- Predicting response to endovascular therapies: Dissecting the roles of local lesion complexity, systemic comorbidity, and clinical uncertainty.
- Role of fluid dynamics and inflammation in intracranial Aneurysm formation.
- Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on Coronary atherosclerotic plaque progression and composition in pigs.
- Modifications of Microvascular EC Surface Modulate Phototoxicity of a Porphycene anti-ICAM-1 Immunoconjugate; Therapeutic Implications.
- c-Cbl, a Ubiquitin E3 Ligase That Targets Active β-Catenin: A NOVEL LAYER OF Wnt SIGNALING REGULATION.
- Thin-capped atheromata with reduced collagen content in pigs develop in Coronary arterial regions exposed to persistently low endothelial shear stress.
- High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: An example with epicardia...
- Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy.
- Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis.
- Impact of flow pulsatility on arterial drug distribution in stent-based therapy.
- Importance of Receptor-Targeted Systems In The Battle Against Atherosclerosis.
- Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor.
- The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells.
- Stent elution rate determines drug deposition and receptor-mediated effects.
- Ultrasound-guided, percutaneous delivery of tissue-engineered endothelial cells to the adventitia of stented arteries controls the response to vascular injury in a por...
- The role of scaffold microarchitecture in engineering endothelial cell immunomodulation.
- The evolution of endothelial regulatory paradigms in cancer biology and vascular repair.
- Assessment of Material By-Product Fate from Bioresorbable Vascular Scaffolds.
- A rattle bag of science and the art of translation.
- Matrix-embedded endothelial cells are protected from the uremic milieu.
- Models of Human Vascular Disease: Is There an Animal of La Mancha?
- Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of Myocardial loading conditions.
- The fiber of modern society.
- Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings.
- Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2.
- Letter by Joynt and Edelman regarding article, "Iatrogenic giant Osborn waves".
- Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with Coronary atheromata with thin fi...
- Stromal endothelial cells directly influence cancer progression.
- Augmentation of postswelling surgical sealant potential of adhesive hydrogels.
- Smooth muscle cells orchestrate the endothelial cell response to flow and injury.
- J waves of Osborn revisited.
- Natural history of experimental Coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound st...
- Cellular bridges: Routes for intercellular communication and cell migration.
- Monocyte activation state regulates monocyte-induced endothelial proliferation through Met signaling.
- Optimal control of blood glucose: the diabetic patient or the machine?
- T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells.
- Revascularization for coronary artery Disease in diabetes mellitus: angioplasty, stents and coronary artery bypass grafting.
- Tubular bridges for bronchial epithelial cell migration and communication.
- Delivery site of perivascular endothelial cell matrices determines control of stenosis in a porcine femoral stent model.
- The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque.
- Vascular growth factor binding kinetics to the endothelial cell basement membrane, with a kinetics-based correction for substrate binding.
- Encapsulated pheochromocytoma cells secrete potent noncatecholamine factors.
- Vascular regeneration by local growth factor release is self-limited by microvascular clearance.
- Echocardiographic capture of right ventricular wall rupture during inferior wall Acute myocardial infarction.
- Pheochromocytoma-induced Cardiomyopathy is modulated by the synergistic effects of cell-secreted factors.
- Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice.
- NF-kappaB activity in endothelial cells is modulated by cell substratum interactions and influences chemokine-mediated adhesion of natural killer cells.
- Function and mode of regulation of endothelial major histocompatibility complex class II.
- Luminal flow amplifies stent-based drug deposition in arterial bifurcations.
- Elevated fibroblast growth factor-2 increases tumor necrosis factor-alpha induced endothelial cell death in high glucose.
- Structural biomechanics modulate intramuscular distribution of locally delivered drugs.
- Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway.
- Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair.
- Prediction of the localization of high-risk Coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopatholo...
- Regulation of endothelial cell proliferation by primary monocytes.
- Risk stratification of individual coronary lesions using local endothelial shear stress: a new paradigm for managing coronary artery Disease.
- Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts.
- Transgenic expression of human C-reactive protein suppresses endothelial nitric oxide synthase expression and bioactivity after vascular injury.
- Role of endothelial shear stress in the natural history of Coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
- Glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability.
- Kruppel-like factor 4 regulates endothelial inflammation.
- Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression.
- Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic models.
- Collagen fragments modulate innate immunity.
- Cell-matrix contact prevents recognition and damage of endothelial cells in states of heightened immunity.
- Cardiology is flow.
- Pushing drug-eluting stents into uncharted territory: simpler than you think--more complex than you imagine.
- Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.
- Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals.
- Matrix embedding alters the immune response against endothelial cells in vitro and in vivo.
- Cells in fluidic environments are sensitive to flow frequency.
- Enhanced T-helper-1 lymphocyte activation patterns in acute Coronary syndromes.
- Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents.
- Thrombosis modulates arterial drug distribution for drug-eluting stents.
- Preclinical evaluation of drug-eluting stents for peripheral applications: recommendations from an expert consensus group.
- Environmental influences on endovascular stent platelet reactivity: an in vitro comparison of stainless steel and gold surfaces.
- Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel.
- Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions.
- Embolic protection with filtering or occlusion balloons during saphenous vein graft stenting retrieves identical volumes and sizes of particulate debris.
- Resonance energy transfer for assessing the molecular integrity of proteins for local delivery.
- Liposomal alendronate inhibits systemic innate immunity and reduces in-stent neointimal hyperplasia in rabbits.
- Treatment with chondroitin sulfate to modulate inflammation and atherogenesis in obesity.
- Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment.
Schools
Harvard Medical School
Brigham Womens Hospital
Procedures Preformed
- Ablation for Treatment of Cardiac Arrhythmias
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardioversion, Elective
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Conditions Treated
- Aneurysm and Dissection of Heart
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomyopathy
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Doctors Specialties
- Cardiology
Accepted Insurances
Awards
- Elected Member
- Fellow (FACC)
Education
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Brigham and Women's Hospital -
Harvard Medical School
Hospital
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Brigham and Women's Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1659369460 |
| Last Name Of The Provider | EDELMAN |
| First Name Of The Provider | ELAZER |
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