Physician
Internal Medicine
Dr. Eliot R. Spindel, MD
Dr. Eliot R. Spindel practices Internal Medicine. He received awards:"Elected Member". Doctor Eliot R. Spindel, MD has written publications. He has 98 publications published with PubMed. The lastest paper is: 'Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with...'
Publications
- Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.
- Vitamin C supplementation ameliorates the adverse effects of nicotine on placental hemodynamics and histology in nonhuman primates.
- Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans.
- Vitamin C Supplementation for Pregnant Smoking Women and Pulmonary Function in Their Newborn Infants: A Randomized Clinical Trial.
- Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis.
- Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model.
- The ly-6 protein, lynx1 is an endogenous inhibitor of nicotinic signaling in airway epithelium.
- Prenatal Nicotine Exposure Alters Lung Function and Airway Geometry Through ?7 Nicotinic Receptors.
- Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant dea...
- Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium.
- Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance.
- Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.
- Is nicotine the estrogen of lung cancer?
- Activated cholinergic signaling provides a target in squamous cell lung carcinoma.
- M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion.
- Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys.
- Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell ...
- Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells.
- Neuronal nicotinic acetylcholine receptors: not just in brain.
- Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.
- Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors.
- Cloning and characterization of cDNAs encoding human gastrin-releasing peptide.
- Thyrotropin-releasing hormone (TRH) content of rat striatum: modification by drugs and lesions.
- Neuroendocrine effects of caffeine. II. Effects on thyrotropin and corticosterone secretion.
- Action of the methylxanthines on the pituitary and pituitary-dependent hormones.
- Increased TRH content of the basal ganglia in Huntington's disease.
- Neuroendocrine effects of caffeine in normal subjects.
- Antibody to hepatitis B surface antigen may not always indicate immunity to hepatitis B virus infection.
- TRH immunoreactivity in rat brain regions, spinal cord and pancreas: validation by high-pressure liquid chromatography and thin-layer chromatography.
- Formation and degradation of deamido-TRH (pyroglutamyl-histidyl-proline) in rat brain after intraventricular injection of TRH.
- Intrathoracic liposarcoma: abnormal regional xenon-133 V/Q study.
- Cloning of a receptor for amphibian [Phe13]bombesin distinct from the receptor for gastrin-releasing peptide: identification of a fourth bombesin receptor subtype (BB4).
- A rhesus monkey model to characterize the role of gastrin-releasing peptide (GRP) in lung development. Evidence for stimulation of airway growth.
- Gastrin-releasing peptide is produced in the pregnant ovine uterus.
- Cloning of complementary DNAs encoding the amphibian bombesin-like peptides Phe8 and Leu8 phyllolitorin from Phyllomedusa sauvagei: potential role of U to C RNA editin...
- Functional analysis of the 5'-flanking region of the human gastrin-releasing peptide gene in small cell lung carcinoma cell lines.
- Bombesin-like peptides: of ligands and receptors.
- Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.
- Roles of bombesin-like peptides in lung development and lung injury.
- There are three distinct forms of bombesin. Identification of [Leu13]bombesin, [Phe13]bombesin, and [Ser3,Arg10,Phe13]bombesin in the frog Bombina orientalis.
- Locations and molecular forms of gastrin-releasing peptide-like immunoreactive entities in ovine pregnancy.
- Gastrin-releasing peptide-like immunoreactivity is present in human maternal and fetal placental membranes.
- Discovery of a high affinity radioligand for the human orphan receptor, bombesin receptor subtype 3, which demonstrates that it has a unique pharmacology compared with...
- Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys.
- Molecular cloning and characterization of two putative G protein-coupled receptors which are highly expressed in the central nervous system.
- Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R).
- Prenatal nicotine exposure alters pulmonary function in newborn rhesus monkeys.
- Chronic maternal nicotine exposure alters neuronal systems in the arcuate nucleus that regulate feeding behavior in the newborn rhesus macaque.
- Muscarinic receptor agonists and antagonists: effects on cancer.
- Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy.
- Large scale analysis of positional effects of single-base mismatches on microarray gene expression data.
- Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure.
- Leveraging human genomic information to identify nonhuman primate sequences for expression array development.
- FSH regulates acetycholine production by ovarian granulosa cells.
- Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta).
- Intercenter reliability and validity of the rhesus macaque GeneChip.
- Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels.
- Synthesis of acetylcholine by lung cancer.
- International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease sta...
- Recruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung.
- Restriction of placental vasculature in a non-human primate: a unique model to study placental plasticity.
- Clinical trial: endoscopic evaluation of naproxen etemesil, a naproxen prodrug, vs. naproxen - a proof-of-concept, randomized, double-blind, active-comparator study.
- Reversed-phase, ion-pair separation of thyrotropin-releasing hormone and some analogs.
- A potent bombesin receptor antagonist inhibits bombesin-stimulated growth of mouse colon cancer cells in vitro: absence of autocrine effects.
- Gastrin-releasing peptide (GRP) is not mammalian bombesin. Identification and molecular cloning of a true amphibian GRP distinct from amphibian bombesin in Bombina ori...
- Simple luminometric assay to detect phosphoinositol-linked receptor expression in Xenopus oocytes.
- Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas.
- Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor.
- Production of neuromedin B and neuromedin B gene expression in human lung tumor cell lines.
- Bombinin-like peptides with antimicrobial activity from skin secretions of the Asian toad, Bombina orientalis.
- Thyroid hormone decreases the stability and the poly(A) tract length of rat thyrotropin beta-subunit messenger RNA.
- Cloning of cDNAs encoding amphibian bombesin: evidence for the relationship between bombesin and gastrin-releasing peptide.
- Anaplastic neoplasm in a patient with hairy cell leukemia.
- Tissue-specific expression of the rat galanin gene.
- Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranat...
- Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary.
- The usefulness of branched chain amino acids in patients with acute or chronic hepatic encephalopathy.
- Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease.
- Analysis of the gene and multiple messenger ribonucleic acids (mRNAs) encoding human gastrin-releasing peptide: alternate RNA splicing occurs in neural and endocrine t...
- Localization of bombesin-like peptides in tumors.
- A frequent Pvu II RFLP of the human gastrin releasing peptide gene.
- Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides.
- Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.
- Human gastrin-releasing peptide gene is located on chromosome 18.
- Localisation of mRNA and co-expression and molecular forms of GRP gene products in endocrine cells of fetal human lung.
- Molecular biology of bombesin-like peptides. Comparison of cDNAs encoding human gastrin-releasing peptide, human neuromedin B, and amphibian ranatensin.
- Decision analysis in evaluation of hypergastrinemia.
- Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells.
- Cerulein mRNA and peptide alpha-amidation activity in the skin of Xenopus laevis: stimulation by norepinephrine.
- Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung.
- Conversion of methionine to homocysteine thiolactone in liver.
- Effects of caffeine on anterior pituitary and thyroid function in the rat.
- Sulfasalazine and folate deficiency.
- Characterization of neuropeptides by reversed-phase, ion-pair liquid chromatography with post-column detection by radioimmunoassay. Application to thyrotropin-releasin...
- Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immu...
- The effects of cysteamine on thyrotropin and immunoreactive beta-endorphin secretion in the rat.
- Chronic active hepatitis.
Schools
Harvard Medical School
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
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