Professor, Pediatrics, Medical College of Wisconsin
Pediatric Nephrology
Dr. Ellis D. Avner, MD
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Doctor Ellis D. Avner, MD is an expert in the field of Pediatric Nephrology. He went to medical school at Perelman School of Medicine at the University of Pennsylvania. Dr. Ellis D. Avner is also published. He has 101 publications published. The lastest publication: "The molecular biology of polycystic kidney disease.'
Publications
- Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy.
- New approaches to the autosomal recessive polycystic kidney disease patient with dual kidney-liver complications.
- G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.
- HDAC6 Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation in Renal Epithelial Cells.
- Role of Genetic Modifiers in an Orthologous Rat Model of ARPKD.
- Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents.
- 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
- Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.
- 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
- Src inhibition ameliorates polycystic kidney disease.
- Renal cystic disease: new insights for the clinician.
- Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: summary statement of a first National Institutes of Health/Office of Rare Diseases confe...
- Haplotype analysis improves molecular diagnostics of autosomal recessive polycystic kidney disease.
- Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats.
- EGF-related growth factors in the pathogenesis of murine ARPKD.
- EGF receptor tyrosine kinase inhibition attenuates the development of PKD in Han:SPRD rats.
- Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability.
- Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells.
- Critical choices in mentoring the next generation of academic pediatricians: nine circles of hell or salvation?
- Refinement of the autosomal recessive polycystic kidney disease (PKHD1) interval and exclusion of an EF hand-containing gene as a PKHD1 candidate gene.
- PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and ...
- Comprehensive management of renal failure in infants.
- Lessons learned in the management of hemolytic uremic syndrome in children.
- Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2 beta, and GSTA1 at 6p21.1-p12.
- Phenotypic analysis of conditionally immortalized cells isolated from the BPK model of ARPKD.
- A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease.
- Can progression of autosomal dominant or autosomal recessive polycystic kidney disease be prevented?
- Expression of the orpk disease gene during kidney development and maturation.
- Childhood ADPKD: answers and more questions.
- Role of CFTR in autosomal recessive polycystic kidney disease.
- Renal dysfunction but not cystic change is ameliorated by neonatal epidermal growth factor in bpk mice.
- Segment-specific c-ErbB2 expression in human autosomal recessive polycystic kidney disease.
- Generation and phenotype of cell lines derived from CF and non-CF mice that carry the H-2K(b)-tsA58 transgene.
- Genomic structure of the gene for the human P1 protein (MCM3) and its exclusion as a candidate for autosomal recessive polycystic kidney disease.
- Proximal tubular cysts in fetal human autosomal recessive polycystic kidney disease.
- Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor.
- Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene.
- Glomerulosclerosis and hypoplasia--a common theme?
- Cellular pathophysiology of cystic kidney disease: insight into future therapies.
- In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor.
- Safety and efficacy of erythropoietin in children with chronic renal failure.
- New insights into the molecular pathophysiology of polycystic kidney disease.
- A 1-Mb BAC/PAC-based physical map of the autosomal recessive polycystic kidney disease gene (PKHD1) region on chromosome 6.
- Pediatric renal transplantation: indications and special considerations. A position paper from the Pediatric Committee of the American Society of Transplant Physicians.
- The molecular biology of polycystic kidney disease.
- PKD and CF: an interesting family provides insight into the molecular pathophysiology of polycystic kidney disease.
- Morphological and functional characterization of a conditionally immortalized collecting tubule cell line.
- Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease.
- Functional genomics in the post-genome era.
- Cholelithiasis following Escherichia coli O157:H7-associated hemolytic uremic syndrome.
- Cell and molecular biology of kidney development.
- Pediatric renal biopsy: should this procedure be performed in an outpatient setting?
- The role of hepatocyte growth factor (HGF) at progressive stages of metanephric development.
- Prenatal diagnosis of autosomal recessive polycystic kidney disease (ARPKD): molecular genetics, clinical experience, and fetal morphology.
- Epidermal growth factor receptor activity mediates renal cyst formation in polycystic kidney disease.
- Efficacy of taxol in the orpk mouse model of polycystic kidney disease.
- Improved outcome of young children on nightly automated peritoneal dialysis.
- Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion.
- An integrated genetic and physical map of the autosomal recessive polycystic kidney disease region.
- Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA.
- Evidence that two phenotypically distinct mouse PKD mutations, bpk and jcpk, are allelic.
- Novel Madin Darby canine kidney cell clones exhibit unique phenotypes in response to morphogens.
- Clinical quiz. Differential diagnosis of a patient with Wegener''s granulomatosis.
- Clinical quiz. Differential diagnosis of a patient with hypertension.
- Congenital nephropathies and uropathies.
- Alternate-day steroid dosing improves growth without adversely affecting graft survival or long-term graft function. A report of the North American Pediatric Renal Tra...
- Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease.
- Normal and abnormal nephrogenesis.
- A new murine model of autosomal recessive polycystic kidney disease.
- Renal developmental diseases.
- Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice.
- Epithelial polarity and differentiation in polycystic kidney disease.
- Escherichia coli O 157:H7-associated hemolytic-uremic syndrome after ingestion of contaminated hamburgers.
- Gene time for polycystic kidney disease.
- Hypercalciuria and nephrocalcinosis in the oculocerebrorenal syndrome.
- Tyrosine kinase activity of the EGF receptor in murine metanephric organ culture.
- Renal transplantation and chronic dialysis in children and adolescents: the 1993 annual report of the North American Pediatric Renal Transplant Cooperative Study.
- The severe perinatal form of autosomal recessive polycystic kidney disease maps to chromosome 6p21.1-p12: implications for genetic counseling.
- Epidermal growth factor receptor expression is abnormal in murine polycystic kidney.
- Clinical disorders of water metabolism: hyponatremia and hypernatremia.
- Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor.
- Metabolic studies of rat renal tubule cells loaded with cystine: the cystine dimethylester model of cystinosis.
- 1 alpha, 25-dihydroxyvitamin D3 receptor ontogenesis in fetal renal development.
- Cystic maldevelopment of the kidney.
- Neonatal radiocontrast nephropathy simulating infantile polycystic kidney disease.
- Metanephric development in serum-free organ culture.
- Mortality of chronic hemodialysis and renal transplantation in pediatric end-stage renal disease.
- Veno-occlusive disease of the liver associated with cysteamine treatment of nephropathic cystinosis.
- An organ culture model for the study of metanephric development.
- Development of renal basement membrane glycoproteins in metanephric organ culture.
- A new model of glucocorticoid-induced metanephric maldevelopment.
- Hydrocortisone-induced cystic metanephric maldevelopment in serum-free organ culture.
- Cyst formation in metanephric organ culture induced by cis-dichlorodiammineplatinum (II).
- Diabetic nephropathy in adolescence: appearance during improved glycemic control.
- Single-dose amoxicillin therapy of uncomplicated pediatric urinary tract infections.
- Effects of improved glycemic control on microalbuminuria in adolescents with insulin-dependent diabetes mellitus.
- Regression of genetically determined polycystic kidney disease in murine organ culture.
- Renal function and somatic growth in pediatric cadaveric renal transplantation with cyclosporine-prednisone immunosuppression.
- Growth factor requirements of organogenesis in serum-free metanephric organ culture.
- Partial characterization and ontogeny of renal cytosolic glucocorticoid receptors in mouse kidney.
Schools
University Of Pennsylvania
Chldns Hospital Med Center
Boston Children39s Hospital
Doctors Specialties
- Pediatric Nephrology
Accepted Insurances
Education
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Boston Children's Hospital -
Perelman School of Medicine at the University of Pennsylvania
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