Professor of Medicine, Dana-Farber Cancer Institute
Internal Medicine
Dr. Ellis L. Reinherz, MD
Dr. Ellis L. Reinherz is an expert in the field of Internal Medicine. He graduated from Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He received 1 awards: "Elected Member". Ellis Reinherz is also a published doctor. He has 64 paper published. The most recent paper is: FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses.
Publications
- Codification of bidentate pMHC interaction with TCR and its co-receptor.
- Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides.
- Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.
- Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.
- Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.
- Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.
- Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry.
- Disruption of Helix-Capping Residues 671 and 674 Reveals A Role in Hiv-1 Entry for A Specialized Hinge Segment of the Membrane Proximal External Region of Gp41.
- Identification of human leucocyte antigen (HLA)-A*0201-restricted cytotoxic T lymphocyte epitopes derived from HLA-DOβ as a novel target for multiple myeloma.
- BlockLogo: Visualization of peptide and sequence motif conservation.
- Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission.
- Revisiting the putative TCR C? dimerization model through structural analysis.
- A New Angle on TCR Activation.
- Impaired B Cell Development and Function in the Absence of I{kappa}BNS.
- Dana-Farber repository for machine learning in immunology.
- Impaired tumor antigen processing by immunoproteasome-expressing CD40-activated B: cells and dendritic cells.
- Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.
- MULTIPRED2: A computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles.
- Molecular Detection of Targeted Major Histocompatibility Complex I-Bound Peptides Using a Probabilistic Measure and Nanospray MS(3) on a Hybrid Quadrupole-Linear Ion T...
- A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers.
- Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.
- Graft-versus-leukemia antigen CML66 elicits coordinated B-cell and T-cell immunity after donor lymphocyte infusion.
- Interactions between lipids and human anti-HIV antibody 4E10 can be reduced without ablating neutralizing activity.
- Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections.
- The alphabeta T cell receptor is an anisotropic mechanosensor.
- Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface.
- Pyrin Modulates the Intracellular Distribution of PSTPIP1.
- PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.
- Immunodominant-peptide recognition: beta testing TCRalphabeta.
- HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.
- Major neutralizing sites on vaccinia virus glycoprotein B5 are exposed differently on variola virus ortholog B6.
- Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption.
- Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.
- Definition of MHC supertypes through clustering of MHC peptide-binding repertoires.
- Prediction of peptide-MHC binding using profiles.
- The TCR C beta FG loop regulates alpha beta T cell development.
- CD2BP1 modulates CD2-dependent T cell activation via linkage to protein tyrosine phosphatase (PTP)-PEST.
- Recognition and classification of histones using support vector machine.
- Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer.
- Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration.
- Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule.
- Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction.
- Comparison of HIV Type 1 ADA gp120 monomers versus gp140 trimers as immunogens for the induction of neutralizing antibodies.
- New approaches to eliciting protective immunity through T cell repertoire manipulation: the concept of thymic vaccination.
- Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
- Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles.
- Peptide variants of viral CTL epitopes mediate positive selection and emigration of Ag-specific thymocytes in vivo.
- Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies.
- A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase.
- Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire.
- Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.
- The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory.
- Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen.
- Prediction of MHC class I binding peptides using profile motifs.
- Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.
- CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.
- Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.
- CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization.
- FluKB: A Knowledge-Based System for Influenza Vaccine Target Discovery and Analysis of the Immunological Properties of Influenza Viruses.
- Human leukocyte antigen typing using a knowledge base coupled with a high-throughput oligonucleotide probe array analysis.
- Forward Vaccinology: CTL Targeting Based upon Physical Detection of HLA-Bound Peptides.
- HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology.
- Large-scale analysis of B-cell epitopes on influenza virus hemagglutinin - implications for cross-reactivity of neutralizing antibodies.
Schools
Harvard Medical School
Massachusetts General Hospital
Peter Bent Brigham Hospital
Doctors Specialties
- Hematology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
-
Brigham and Women's Hospital -
Massachusetts General Hospital -
Harvard Medical School
Hospital
-
Dana-Farber Cancer Institute
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