Professor, Anesthesiology, Washington University School of Medicine
Anesthesiology
Dr. Evan D. Kharasch, MD
Evan Kharasch works in the field of Anesthesiology. He attended Northwestern University Feinberg School of Medicine. Northwestern University Feinberg School of Medicine has a rank of 19 in research and a 29 in primary care Evan Kharasch is also a published doctor. He has 101 paper published. The most recent paper is: Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human... Doctor Evan D. Kharasch, MD accepts Medicare.
Publications
- Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human...
- Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.
- Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?
- Influence of HIV antiretrovirals on methadone N-demethylation and transport.
- The Hematological Effects of Nitrous Oxide Anesthesia in Pediatric Patients.
- Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer.
- Cyclosporine-inhibitable Cerebral Drug Transport Does Not Influence Clinical Methadone Pharmacodynamics.
- Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.
- Automated radiochemical synthesis and biodistribution of [(11)C]l-α-acetylmethadol ([(11)C]LAAM).
- Bioplasmonic calligraphy for multiplexed label-free biodetection.
- Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update.
- Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade.
- High-sensitivity analysis of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in plasma and urine by liquid chromatography-...
- Cytochrome P4503A does not mediate the interaction between methadone and ritonavir/lopinavir.
- Assessing the utility of the utility function.
- Significance of Lipid Composition in a Blood-Brain Barrier-Mimetic PAMPA Assay.
- Cyclosporine-inhibitable Blood-Brain Barrier Drug Transport Influences Clinical Morphine Pharmacodynamics.
- Mechanism of autoinduction of methadone N-demethylation in human hepatocytes.
- Sleeping to Survive?: The Impact of Volatile Anesthetics on Mortality in Sepsis.
- The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma.
- Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
- Meta-analysis of CYP2D6 Metabolizer Phenotype and Metoprolol Pharmacokinetics.
- Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing.
- Methadone N-demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6.
- Role of Cytochrome P4502B6 in Methadone Metabolism and Clearance.
- Getting Oil and Water to Mix.
- Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin or Bupropion.
- Perioperative Pharmacokinetics of Methadone in Adolescents.
- Buprenorphine Metabolites, Buprenorphine-3-glucuronide and Norbuprenorphine-3-glucuronide, Are Biologically Active.
- Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6 and 2C9 by Riton...
- Sensitivity and Specificity of Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 for the Diagnosis of Renal Cell Carcinoma.
- The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.
- Nitrous Oxide Anesthesia and Plasma Homocysteine in Adolescents.
- Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir.
- Chemical and Enzyme-Assisted Syntheses of Norbuprenorphine-3-β-d-glucuronide.
- Headache outcomes following treatment of unruptured intracranial aneurysms: A prospective analysis.
- Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?
- Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.
- Urinary biomarkers for the early diagnosis of kidney cancer.
- The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6...
- Contemporary clinical opioid use: opportunities and challenges.
- Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.
- Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonav...
- Mutations in a molecule: the virtues of antagonism.
- Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting.
- Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.
- Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.
- Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.
- Role of CYP2B6 in stereoselective human methadone metabolism.
- Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
- Every breath you take, we'll be watching you.
- Pharmacokinetic interactions between buprenorphine and antiretroviral medications.
- Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities.
- New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.
- New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic path...
- Stereochemical aspects of itraconazole metabolism in vitro and in vivo.
- Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") ...
- Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.
- Influence of sevoflurane on the metabolism and renal effects of compound A in rats.
- Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
- Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
- CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.
- Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.
- Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
- Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.
- Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.
- Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
- Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.
- Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.
- Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluorome...
- Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.
- Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
- Toxicity during tumescent lipoplasty: a commentary.
- Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.
- Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
- Perioperative COX-2 inhibitors: knowledge and challenges.
- Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.
- Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular ...
- Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spec...
- CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.
- Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia.
- Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.
- Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fe...
- Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.
- Disposition of nasal, intravenous, and oral methadone in healthy volunteers.
- Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.
- Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)v...
- Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol.
- Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.
- Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Codeine Therapy in the Context of Cytochrome P450 2D6 (CYP2D6) Genotype.
- Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
- Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
- Plasma levels of 2% lidocaine with 1:100,000 epinephrine with young children undergoing dental procedures.
- Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.
- Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.
- Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
- Adverse drug reactions with halogenated anesthetics.
- Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.
- Left ventricular free wall rupture in acute myocardial infarction--a spectrum of severity.
- Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.
Schools
Northwestern Center Feinberg School of Medicine
University of Washington
Doctors Specialties
- Anesthesiology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Cigna HMO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Coventry Health Care of Missouri PPO
- Medicare MCR
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Education
-
University of Washington -
Northwestern University Feinberg School of Medicine
Hospital
-
Barnes-Jewish Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1780602219 |
| Last Name Of The Provider | KHARASCH |
| First Name Of The Provider | EVAN |
| View All |
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