Physician

Internal Medicine

Francisco R. Carbone, MD works in the field of Internal Medicine. He graduated from Medical College of Wisconsin. Medical College of Wisconsin is ranked 54/62 in Research/PrimaryCare. Francisco R. Carbone, MD is a published doctor. He published 101 publications, including: 'T-cell receptor contact and MHC binding residues of a major rye grass pollen allergen T-cell epitope.'

Publications

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• [Regressive atypical histiocytosis (or Ki-1 lymphoma of the skin). Presentation of a case with an immunohistochemical study].
• Structure-activity studies of melatonin analogues in prepubertal male rats.
• Monoclonal antibodies to horse cytochrome c expressing four distinct idiotypes distribute among two sites on the native protein.
• Quantum critical behaviour in a high-T(c) superconductor.
• Processing of a minimal antigenic peptide alters its interaction with MHC molecules.
• Identification of a gastritogenic epitope of the H/K ATPase beta-subunit.
• T cell receptor (TCR) antagonism without a negative signal: evidence from T cell hybridomas expressing two independent TCRs.
• Carbohydrates and antigen recognition by T cells.
• The use of hydrophobic, alpha-helix-defined peptides in delineating the T cell determinant for pigeon cytochrome c.
• Conformational difference of T cell antigen receptors revealed by monoclonal antibodies to mouse V beta 5 T cell receptor for antigen determinants.
• T-cell receptor contact and MHC binding residues of a major rye grass pollen allergen T-cell epitope.
• A new T helper cell specificity within the pigeon cytochrome c determinant 95-104.
• Peptide presentation by class-I major histocompatibility complex molecules.
• pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein.
• Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor.
• Conformational constraints involved in MHC class I restricted antigen presentation.
• Both intrathymic and peripheral selection modulate the differential expression of V beta 5 among CD4+ and CD8+ T cells.
• Electroporation and commercial liposomes efficiently deliver soluble protein into the MHC class I presentation pathway. Priming in vitro and in vivo for class I-restri...
• T cell receptor antagonist peptides induce positive selection.
• The effect of mutations in the MHC class I peptide binding groove on the cytotoxic T lymphocyte recognition of the Kb-restricted ovalbumin determinant.
• T cell receptor alpha-chain pairing determines the specificity of residue 262 within the Kb-restricted, ovalbumin257-264 determinant.
• Changes at peptide residues buried in the major histocompatibility complex (MHC) class I binding cleft influence T cell recognition: a possible role for indirect confo...
• Introduction of soluble protein into the class I pathway of antigen processing and presentation.
• Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytot...
• CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose.
• Class I MHC-restricted cytotoxic responses to soluble protein antigen.
• Induction of antigen-specific class I-restricted cytotoxic T cells by soluble proteins in vivo.
• The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant.
• Cross-presentation: a general mechanism for CTL immunity and tolerance.
• B cells directly tolerize CD8(+) T cells.
• Characterization of diverse primary herpes simplex virus type 1 gB-specific cytotoxic T-cell response showing a preferential V beta bias.
• Cross-tolerance: a pathway for inducing tolerance to peripheral tissue antigens.
• Contrast between class I and class II MHC-mediated differentiation of a CD4+CD8+ T cell line: implications for lineage commitment.
• Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.
• A dominant V beta bias in the CTL response after HSV-1 infection is determined by peptide residues predicted to also interact with the TCR beta-chain CDR3.
• Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells.
• Cross-presentation in viral immunity and self-tolerance.
• Cross-presentation, dendritic cells, tolerance and immunity.
• Activation and migration of CD8 T cells in the intestinal mucosa.
• Cross-presentation of self antigens to CD8+ T cells: the balance between tolerance and autoimmunity.
• Loss of antiviral cytotoxic T-lymphocyte activity during high-level antigen stimulation.
• Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection.
• Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus.
• Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells.
• Induction of autoimmune diabetes by oral administration of autoantigen.
• Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells.
• Down-modulation of CD8 beta-chain in response to an altered peptide ligand enables developing thymocytes to escape negative selection.
• CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes.
• T cell receptor V alpha bias can be determined by TCR-contact residues within an MHC-bound peptide.
• Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant.
• Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.
• Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.
• Peptide-dependent recognition of H-2Kb by alloreactive cytotoxic T lymphocytes.
• Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides.
• Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.
• Expression of two T cell receptor alpha chains on the surface of normal murine T cells.
• The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo.
• Inhibition of naïve class I-restricted T cells by altered peptide ligands.
• CD30 prevents T-cell responses to non-lymphoid tissues.
• The cytotoxic T-cell response to herpes simplex virus type 1 infection of C57BL/6 mice is almost entirely directed against a single immunodominant determinant.
• Cytotoxic T lymphocyte activation by cross-priming.
• Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigens.
• Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements.
• CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity.
• The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1).
• Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction.
• Help for cytotoxic-T-cell responses is mediated by CD40 signalling.
• Peptide-induced deletion of CD8 T cells in vivo occurs via apoptosis in situ.
• Antigen-specific CD8+ T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection.
• Evidence for cooperation between TCR V region and junctional sequences in determining a dominant cytotoxic T lymphocyte response to herpes simplex virus glycoprotein B.
• Functional mapping of the orientation for TCR recognition of an H2-Kb-restricted ovalbumin peptide suggests that the beta-chain subunit can dominate the determination ...
• Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help.
• Constitutive class I-restricted exogenous presentation of self antigens in vivo.
• TCR alpha-chain usage can determine antigen-selected TCR beta-chain repertoire diversity.
• Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion.
• Class I-restricted presentation occurs without internalization or processing of exogenous antigenic peptides.
• MHC class II expression is regulated in dendritic cells independently of invariant chain degradation.
• A key role for ICAM-1 in generating effector cells mediating inflammatory responses.
• Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo.
• Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1.
• Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection.
• A bone marrow-derived APC in the gut-associated lymphoid tissue captures oral antigens and presents them to both CD4+ and CD8+ T cells.
• The role of dendritic cell subsets in immunity to viruses.
• Cross-presentation of antigens by dendritic cells.
• Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes.
• Hide and seek: the immunology of HSV persistence.
• Cutting edge: conventional CD8 alpha+ dendritic cells are preferentially involved in CTL priming after footpad infection with herpes simplex virus-1.
• The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells.
• Detection of low-avidity CD4+ T cells using recombinant artificial APC: following the antiovalbumin immune response.
• The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens.
• Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim.
• The role of dendritic cell subsets in selection between tolerance and immunity.
• CD36 is differentially expressed by CD8+ splenic dendritic cells but is not required for cross-presentation in vivo.
• Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.
• Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice.
• The cross-priming APC requires a Rel-dependent signal to induce CTL.
• Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and...
• Cutting edge: precursor frequency affects the helper dependence of cytotoxic T cells.
• Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1.
• Pillars article: T cell receptor antagonist peptides induce positive selection. Cell. 1994. 76: 17-27.

Schools

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• Medical College of Wisconsin

Doctors Specialties

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• Psychiatry
• Internal Medicine

Accepted Insurances

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Education

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• Medical College of Wisconsin

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