Professor of Anaesthesia, Harvard Medical School, Massachusetts General Hospital
Anesthesiology
Dr. Fumito Ichinose, MD
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Fumito Ichinose practices Anesthesiology. He went to medical school at Graduate School of Medicine and Faculty of Medicine, The University of Tokyo. Dr. Fumito Ichinose is a published physician. He has 101 papers published. The most current publication "Platelet hyporeactivity in young infants during cardiopulmonary bypass." Fumito Ichinose, MD accepts Medicare payments and is registered with Medicare.gov.
Publications
- S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.
- Trapping Hydrogen Sulfide (H2S) with Diselenides: The Application in the Design of Fluorescent Probes.
- Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice.
- Sodium Thiosulfate Attenuates Acute Lung Injury in Mice.
- Farnesyltransferase Inhibitor, Tipifarnib, Prevents Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure.
- Toll-like Receptor 4 Is Essential to Preserving Cardiac Function and Survival in Low-grade Polymicrobial Sepsis.
- Successful Right Ventricular Mechanical Support after Combined Heart-Liver Transplantation.
- OP05 Cystathionine γ-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure.
- Cystathionine γ-Lyase Deficiency Protects Mice from Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure.
- Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression.
- Improving outcomes after cardiac arrest using NO inhalation.
- Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice.
- A novel hydrogen sulfide-releasing NMDA receptor antagonist prevents ischemic neuronal death.
- Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice.
- 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells.
- Tidal lung recruitment and exhaled nitric oxide during coronary artery bypass grafting in patients with and without chronic obstructive pulmonary disease.
- Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance.
- Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury.
- The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis.
- Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.
- Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice.
- Cysteinyl Leukotrienes Impair Hypoxic Pulmonary Vasoconstriction in Endotoxemic Mice.
- Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice.
- Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease.
- sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling.
- The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning.
- Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease.
- Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on met...
- Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice.
- [Emerging role of hydrogen sulfide in biology].
- Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis.
- Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis.
- Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice.
- sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models.
- Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice.
- Myocardial alterations in senescent mice and effect of exercise training: a strain rate imaging study.
- Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury.
- Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.
- Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.
- Inhaled nitric oxide enables artificial blood transfusion without hypertension.
- Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse.
- [Impact of nitric oxide synthase 3 on myocardial dysfunction in sepsis].
- Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice.
- Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury.
- In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice.
- Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling res...
- Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.
- Inhaled NO as a therapeutic agent.
- Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.
- Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock.
- Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury.
- Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury.
- Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice.
- Inhaled nitric oxide does not reduce systemic vascular resistance in mice.
- Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension.
- 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.
- Quantitative assessment of regional myocardial function in mice by tissue Doppler imaging: comparison with hemodynamics and sonomicrometry.
- Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis.
- NOS3 deficiency augments hypoxic pulmonary vasoconstriction and enhances systemic oxygenation during one-lung ventilation in mice.
- Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia.
- BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.
- Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs.
- Relationship of systolic dysfunction to area at risk and infarction size after ischemia-reperfusion in mice.
- Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential.
- Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency.
- Inhaled nitric oxide in pediatric cardiac surgery.
- A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice.
- Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice.
- Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction.
- Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide.
- Electroencephalographic responses to the formalin test in rats.
- Platelet hyporeactivity in young infants during cardiopulmonary bypass.
- Effects of xenon on the performance of various respiratory flowmeters.
- Lack of correlation between the reduction of sevoflurane MAC and the cerebellar cyclic GMP concentrations in mice treated with 7-nitroindazole.
- The placement of the cuffed oropharyngeal airway with sevoflurane in adults: a comparison with the laryngeal mask airway.
- The cuffed oropharyngeal airway, a novel adjunct to the management of difficult airways.
- Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia.
- The blood-gas partition coefficient of xenon may be lower than generally accepted.
- Selective pulmonary vasodilation induced by aerosolized zaprinast.
- Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension.
- Emergence times from xenon anaesthesia are independent of the duration of anaesthesia.
- Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene.
- Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane.
- Echocardiographic evaluation of global left ventricular function during high thoracic epidural anesthesia.
- Effects of nitroglycerin infusion on segmental wall motion abnormalities after anesthetic induction.
- Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia.
- Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs.
- Exhaled nitric oxide as a marker for organic nitrate tolerance.
- Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia.
- Brief inhalation of nitric oxide increases resuscitation success and improves 7-day-survival after cardiac arrest in rats: a randomized controlled animal study.
- Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65.
- Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats.
- Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension.
- Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice.
- Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms.
- Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice.
- Emergence agitation after sevoflurane versus propofol in pediatric patients.
- Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice.
- Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily.
- The effects of heparin coating of oxygenator fibers on platelet adhesion and protein adsorption.
Doctors Specialties
- Anesthesiology
Accepted Insurances
Education
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Massachusetts General Hospital -
Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
Hospital
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Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1780674812 |
| Last Name Of The Provider | ICHINOSE |
| First Name Of The Provider | FUMITO |
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