Physician
Internal Medicine
Dr. Garret A. Fitzgerald, MD
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Garret Fitzgerald is an expert in the field of Internal Medicine. He has 1 awards "Elected Member". Garret Fitzgerald is a published MD. He has 100 publications published. The most current publication "Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival."
Publications
- Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.
- Confluence, Not Conflict of Interest: Name Change Necessary.
- PharmGKB summary: ibuprofen pathways.
- Selective COX-2 Inhibitors Suppress Prostacyclin.
- Circadian Rhythms. Temporal targets of drug action.
- Time in motion: the molecular clock meets the microbiome.
- Myeloid COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T lymphocyte function.
- Testing cardiovascular drug safety and efficacy in randomized trials.
- Causal effects of body mass index on cardiometabolic traits and events: a mendelian randomization analysis.
- Cyclooxygenase-2 in Endothelial and Vascular Smooth Muscle Cells Restrains Atherogenesis in Hyperlipidemic Mice.
- Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.
- Knitting up the raveled sleave of care.
- Niacin, an old drug with a new twist.
- Response to letters regarding article, "drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin".
- Anecdotes from ITMAT: Building Capacity for Translational Science.
- The Sharing Partnership for Innovative Research in Translation (SPIRiT) Consortium: A Model for Collaboration across CTSA Sites.
- PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells.
- Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44.
- Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.
- Loci influencing blood pressure identified using a cardiovascular gene-centric array.
- Platelet microRNAs: Novy Mir* or Mired in Human Complexity?
- COX-2, the dominant source of prostacyclin.
- Obesity in mice with adipocyte-specific deletion of clock component Arntl.
- Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin.
- Cell Selective Cardiovascular Biology of Microsomal Prostaglandin E Synthase-1.
- Between a ROCK and a Hard Place: How to Align our Circadian Rhythms?
- Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images.
- Medicine. Can intellectual property save drug development?
- "What great creation".
- (Almost) Everything is Illuminated: Adenosine Shines a Light on Cardioprotection.
- Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649.
- Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice.
- Prostaglandin d2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.
- Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis.
- A rattle bag of science and the art of translation.
- Prostaglandin I2 Promotes the Development of IL-17-Producing {gamma}{delta} T Cells That Associate with the Epithelium during Allergic Lung Inflammation.
- Re-engineering drug discovery and development.
- Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors.
- NCATS Purrs: Emerging Signs of Form and Function.
- Prostaglandins and inflammation.
- Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
- Dietary {alpha}-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.
- Efficient drug approval and monitoring must rely on sound regulatory science.
- Cardiovascular biology of microsomal prostaglandin e synthase-1.
- Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness.
- Perestroika in pharma: evolution or revolution in drug development?
- Targeted deletions of cyclooxygenase-2 and atherogenesis in mice.
- Training translators for smart drug discovery.
- Circadian clocks and vascular function.
- Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice.
- Emotion recollected in tranquility: lessons learned from the COX-2 saga.
- The role of clock genes in pharmacology.
- A roadmap for the twilight zone: navigating United States cardiovascular career development for international trainees.
- Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation.
- Platelets, pyrexia, and plasmodia.
- Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis.
- Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function.
- Prostanoids in health and disease.
- Network features of the mammalian circadian clock.
- COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice.
- Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor.
- Guest authorship, mortality reporting, and integrity in rofecoxib studies.
- Drugs, industry, and academia.
- Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.
- Analysis of the zebrafish proteome during embryonic development.
- The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans.
- Genetic components of the circadian clock regulate thrombogenesis in vivo.
- Reduced nitric oxide causes age-associated impairment of circadian rhythmicity.
- Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation.
- Translational therapeutics at the platelet vascular interface. Summary.
- Translational therapeutics at the platelet vascular interface. Introduction.
- Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans.
- Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.
- Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling.
- Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.
- Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma.
- COX-2 inhibitors and cardiovascular risk.
- Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products.
- Peripheral circadian clocks in the vasculature.
- Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor ga...
- Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction?
- EBP, a program for protein identification using multiple tandem mass spectrometry datasets.
- Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells.
- Circadian variation of blood pressure and the vascular response to asynchronous stress.
- Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.
- Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality.
- Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: a detailed HPLC/MS/MS method.
- Oxidized derivatives of omega-3 fatty acids: identification of IPF3 alpha-VI in human urine.
- Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis.
- COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis.
- Genetic model of selective COX2 inhibition reveals novel heterodimer signaling.
- Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function.
- Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center.
- Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.
- Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts.
- Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2.
- Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities.
- Bioinformatic analysis of circadian gene oscillation in mouse aorta.
- Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
Doctors Specialties
- Cardiology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Hospital
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Hospital of the University of Pennsylvania
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