Professor, Neurology, Oregon Health and Science University School of Medicine
Neurology
Dr. Gary L. Westbrook, MD
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Gary Westbrook is an expert in the field of Neurology. He studied medicine at Case Western Reserve University School of Medicine. He has 2 awards "Elected Member" and "Whos Who in Medicine and Healthcare". Gary L. Westbrook, MD is a published physician as well. He has 101 publications published. The latest was: Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.
Publications
- The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist.
- Neurologic impairment following closed head injury predicts post-traumatic neurogenesis.
- Dual-transmitter neurons: functional implications of co-release and co-transmission.
- Hierarchical excitatory synaptic connectivity in mouse olfactory cortex.
- Triheteromeric NMDA Receptors at Hippocampal Synapses.
- Neural injury alters proliferation and integration of adult-generated neurons in the dentate gyrus.
- Structural plasticity in the dentate gyrus- revisiting a classic injury model.
- Distinct Modes of Dopamine and GABA Release in a Dual Transmitter Neuron.
- Amino-Terminal Ligands Prolong NMDA Receptor-Mediated EPSCs.
- Membrane and synaptic properties of pyramidal neurons in the anterior olfactory nucleus.
- Dentate gyrus neurogenesis, integration and microRNAs.
- Pten knockdown in vivo increases excitatory drive onto dentate granule cells.
- miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus.
- microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus.
- Experience-dependent maturation of the glomerular microcircuit.
- Direct actions of carbenoxolone on synaptic transmission and neuronal membrane properties.
- External tufted cells drive the output of olfactory bulb glomeruli.
- Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling.
- Co-transmission of dopamine and GABA in periglomerular cells.
- Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
- Seizures accelerate functional integration of adult-generated granule cells.
- Probing N-methyl-D-aspartate receptor desensitization with the substituted-cysteine accessibility method.
- Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons.
- Delayed development of adult-generated granule cells in dentate gyrus.
- Lateral excitation within the olfactory bulb.
- Functional maturation of adult-generated granule cells.
- GABAergic signaling to newborn neurons in dentate gyrus.
- SK channel regulation of dendritic excitability and dendrodendritic inhibition in the olfactory bulb.
- Connexin36 mediates spike synchrony in olfactory bulb glomeruli.
- Detecting activity in olfactory bulb glomeruli with astrocyte recording.
- A transgenic marker for newly born granule cells in dentate gyrus.
- Synapse density regulates independence at unitary inhibitory synapses.
- AMPA autoreceptors drive correlated spiking in olfactory bulb glomeruli.
- Mobile NMDA receptors at hippocampal synapses.
- Intracellular domains of NR2 alter calcium-dependent inactivation of N-methyl-D-aspartate receptors.
- Neuroligin-1 knockdown reduces survival of adult-generated newborn hippocampal neurons.
- Fatty acids increase neuronal hypertrophy of Pten knockdown neurons.
- Vancomycin-resistant enterococci colonization in patients at seven hemodialysis centers.
- Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse.
- Tufted cell dendrodendritic inhibition in the olfactory bulb is dependent on NMDA receptor activity.
- Slow desensitization regulates the availability of synaptic GABA(A) receptors.
- Incidence and identification of Klebsiella planticola in clinical isolates with emphasis on newborns.
- An orphan glutamate channel points the way to the gates.
- Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit.
- Regulation of synaptic timing in the olfactory bulb by an A-type potassium current.
- The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro.
- Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.
- Defining affinity with the GABAA receptor.
- Dendrodendritic inhibition in the olfactory bulb is driven by NMDA receptors.
- N-terminal domains in the NR2 subunit control desensitization of NMDA receptors.
- Activation kinetics of AMPA receptor channels reveal the number of functional agonist binding sites.
- Evaluation of Vitek GNI+ and Becton Dickinson Microbiology Systems Crystal E/NF identification systems for identification of members of the family Enterobacteriaceae a...
- Shaping of IPSCs by endogenous calcineurin activity.
- Modulation of mEPSCs in olfactory bulb mitral cells by metabotropic glutamate receptors.
- Immunolocalization of metabotropic glutamate receptor 7 in the rat olfactory bulb.
- Cytoskeletal interactions with glutamate receptors at central synapses.
- The impact of receptor desensitization on fast synaptic transmission.
- Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile.
- Calcium-dependent inactivation of recombinant N-methyl-D-aspartate receptors is NR2 subunit specific.
- Metabotropic glutamate receptors activate G-protein-coupled inwardly rectifying potassium channels in Xenopus oocytes.
- Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain.
- Modulation of calcium currents by a metabotropic glutamate receptor involves fast and slow kinetic components in cultured hippocampal neurons.
- Glutamate receptors and excitotoxicity.
- Rundown of N-methyl-D-aspartate channels during whole-cell recording in rat hippocampal neurons: role of Ca2+ and ATP.
- Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons.
- Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors.
- Kinetics of AP5 dissociation from NMDA receptors: evidence for two identical cooperative binding sites.
- Nonuniform probability of glutamate release at a hippocampal synapse.
- Calcium-dependent inactivation of synaptic NMDA receptors in hippocampal neurons.
- Calcium-induced actin depolymerization reduces NMDA channel activity.
- Inactivation of NMDA channels in cultured hippocampal neurons by intracellular calcium.
- L-2-amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1 alpha and 5 in Xenopus oocytes.
- Desensitized states prolong GABAA channel responses to brief agonist pulses.
- Synaptic NMDA receptor channels have a low open probability.
- Glutamate receptor update.
- A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.
- Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones.
- Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity.
- Electrophysiological techniques in dissociated tissue culture.
- Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp.
- Glutamate currents in mammalian spinal neurons: resolution of a paradox.
- Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide.
- Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.
- High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture.
- NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones.
- Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique.
- Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones.
- The physiology of excitatory amino acids in the vertebrate central nervous system.
- Synaptic excitation in cultures of mouse spinal cord neurones: receptor pharmacology and behaviour of synaptic currents.
- Modulation of excitatory synaptic transmission by glycine and zinc in cultures of mouse hippocampal neurons.
- Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide.
- The action of N-methyl-D-aspartic acid on mouse spinal neurones in culture.
- Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones.
- Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones.
- Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III.
- The membrane action of excitatory amino acids on cultured mouse spinal cord neurons.
- Early development of voltage-dependent sodium currents in cultured mouse spinal cord neurons.
- Voltage-gated currents in identified rat olfactory receptor neurons.
- Excitatory synaptic transmission in cultures of rat olfactory bulb.
- Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents.
Schools
Case Western Reserve University School of Medicine
Mt Auburn Hospital
Barnes Jewish Hospital
National Institute Of Health
Doctors Specialties
- Internal Medicine
- Neurology
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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Washington University - Barnes-Jewish Hospital -
Case Western Reserve University School of Medicine
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