Professor, Medicine, UCSD School of Medicine
Internal Medicine
Dr. Gary S. Firestein, MD
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Doctor Gary S. Firestein, MD practices Internal Medicine. He graduated from Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical college. Johns Hopkins University School of Medicine has a rank of 3 in research and a 29 in primary care He received 4 awards: "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Fellow" and "Fellow (FACR)". Dr. Gary S. Firestein is a published doctor. He published 102 publications, including: 'Computationally expanding Infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis.' He is registered with Medicare and accepts Medicare payments.
Publications
- Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside.
- Anti-Inflammatory Effects and Joint Protection in Collagen-induced Arthritis Following Treatment with IQ-1S, a Selective c-Jun N-terminal Kinase Inhibitor.
- The Rheumatoid Arthritis Risk Gene, LBH, Regulates Growth in Fibroblast-like Synoviocytes.
- Validation of Gene Expression Biomarker Analysis for Biopsy-based Clinical Trials in Crohn's Disease.
- TGFβ responsive tyrosine phosphatase promotes Rheumatoid synovial fibroblast invasiveness.
- The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid Arthritis.
- Choline kinase inhibition in rheumatoid Arthritis.
- Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.
- Differential Distribution of PI3K Isoforms in Spinal Cord and Dorsal Root Ganglia: Potential Roles in Acute Inflammatory Pain.
- Phosphoinositide 3-Kinase δ Regulates Migration and Invasion of Synoviocytes in Rheumatoid Arthritis.
- Novel dual phosphoinositide 3-kinase-δ,γ inhibitor: Potent anti-inflammatory effects and joint protection in models of rheumatoid Arthritis.
- Epigenetics in rheumatoid Arthritis: a primer for rheumatologists.
- Regulation of DNA methylation in rheumatoid Arthritis synoviocytes.
- ASIC3 deficiency increases inflammation but decreases pain behavior in Arthritis.
- PTPome profile of rheumatoid Arthritis fibroblast-like synoviocytes: a novel role for SHP-2 as a modulator of invasion and survival.
- Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors.
- Pre-rheumatoid Arthritis: predisposition and transition to clinical synovitis.
- Antiinflammatory functions of p38 in mouse models of rheumatoid Arthritis: Advantages of targeting upstream kinases MKK-3 or MKKk-6.
- The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection.
- DNA methylome signature in rheumatoid Arthritis.
- Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice.
- PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid Arthritis.
- The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon.
- Decreased collagen-induced Arthritis severity and adaptive immunity in mitogen activated protein kinase kinase 6 -deficient mice.
- A systems biology approach to synovial joint lubrication in health, injury, and Disease.
- Suppression of collagen-induced Arthritis in growth arrest and DNA damage inducible 45? (Gadd45?)-deficient mice.
- Synoviocyte innate immune responses: TANK-binding kinase-1 as a potential therapeutic target in rheumatoid Arthritis.
- JNK1 deficiency limits macrophage mediated antigen-induced Arthritis.
- JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory Arthritis.
- Inflammatory mediators promote production of shed LRP1/CD91, which regulates Cell signaling and cytokine expression by macrophages.
- Regulation of peripheral inflammation by the central nervous system.
- Synoviocyte innate immune responses: II. Pivotal role of IFN regulatory factor 3.
- Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor.
- Metabolism: from bench to bedside.
- Interactive cytokine regulation of synoviocyte lubricant secretion.
- Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory Arthritis through the activation of myeloid cell apoptosis.
- Role of interleukin 17 in Arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression.
- Somatic mutations and anti-mutated citrullinated vimentin antibodies in rheumatoid Arthritis: comment on the editorial by Levesque et al.
- Gadd45beta deficiency in rheumatoid Arthritis: enhanced synovitis through JNK signaling.
- Role of MAPK kinase 6 in Arthritis: distinct mechanism of action in inflammation and cytokine expression.
- Inflammasome-mediated Disease animal models reveal roles for innate but not adaptive immunity.
- An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid Arthritis.
- Rheumatoid Arthritis in a mouse?
- Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor.
- Acoustic trauma augments the cochlear immune response to antigen.
- Spinal p38 MAP kinase regulates peripheral cholinergic outflow.
- Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases.
- Primer: signal transduction in rheumatic Disease--a clinician's guide.
- Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2/adenovirus E1B 19-kd protein-interacting protein 3.
- Antiviral gene expression in rheumatoid Arthritis: role of IKKepsilon and interferon regulatory factor 3.
- Biomedicine. Every joint has a silver lining.
- Acquisition, culture, and phenotyping of synovial fibroblasts.
- Anakinra for the treatment of neonatal-onset multisystem inflammatory Disease.
- A biomarker by any other name...
- Reduction of proinflammatory cytokine expression in the synovium by targeting IKKbeta in vivo in a rat model.
- Regulation of peripheral inflammation by spinal p38 MAP kinase in rats.
- Effect of impact on chondrocyte viability during insertion of human osteochondral grafts.
- Amelioration of Arthritis by intraarticular dominant negative Ikk beta gene therapy using adeno-associated virus type 5.
- Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.
- A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes.
- Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory Arthritis.
- PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes.
- Inhibiting inflammation in rheumatoid Arthritis.
- Transforming growth factor beta expression during an inner ear immune response.
- Regulation of Arthritis by p53: critical role of adaptive immunity.
- Immunologic mechanisms in the pathogenesis of rheumatoid Arthritis.
- Regulation of c-Jun phosphorylation by the I kappa B kinase-epsilon complex in fibroblast-like synoviocytes.
- TLR2 signaling in chondrocytes drives calcium pyrophosphate dihydrate and monosodium urate crystal-induced nitric oxide generation.
- Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.
- Fibroblast-like synoviocytes derived from patients with rheumatoid Arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased...
- Telomerase-transduced osteoarthritic fibroblast-like synoviocyte Cell line.
- The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid Arthritis.
- NF-kappaB: Holy Grail for rheumatoid Arthritis?
- P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex.
- Signal transduction in rheumatoid Arthritis.
- Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid Arthritis.
- Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid Arthritis.
- Retinoblastoma suppression of matrix metalloproteinase 1, but not interleukin-6, through a p38-dependent pathway in rheumatoid Arthritis synovial fibroblasts.
- Regulation of peripheral inflammation by spinal adenosine: role of somatic afferent fibers.
- Measurement of inflammatory biomarkers in synovial tissue extracts by enzyme-linked immunosorbent assay.
- Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid Arthritis and their role as key regulators of JNK.
- Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation.
- HIF-1alpha is essential for myeloid Cell-mediated inflammation.
- Microsatellite instability and suppressed DNA repair enzyme expression in rheumatoid Arthritis.
- IL-6 and matrix metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts.
- Spinal adenosine receptor activation inhibits inflammation and joint destruction in rat adjuvant-induced Arthritis.
- Tumor necrosis factor-alpha, an initiator, and etanercept, an inhibitor of cochlear inflammation.
- Regional analysis of p53 mutations in rheumatoid Arthritis synovium.
- Innate immunity as a hired gun: but is it rheumatoid Arthritis?
- DNA microarrays: boundless technology or bound by technology? Guidelines for studies using microarray technology.
- Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced Arthritis.
- How important are T cells in Chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end.
- The genetics of the target tissue in rheumatoid Arthritis.
- Expression and regulation of aggrecanase in Arthritis: the role of TGF-beta.
- Immunostimulatory DNA sequences influence the course of adjuvant Arthritis.
- Regulation of joint destruction and inflammation by p53 in collagen-induced Arthritis.
- Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis: A Synovial Biopsy Study.
- Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid Arthritis.
- A 24-week, randomized, double-blind, placebo-controlled, parallel group study of the efficacy of oral SCIO-469, a p38 mitogen-activated protein kinase inhibitor, in pa...
- Computationally expanding Infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid Arthritis.
- Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Schools
Johns Hopkins University School Of Medicine
UCLA Med Center
Ucsd Med Center
Procedures Preformed
- Joint Drainage
Conditions Treated
- Adhesive Capsulitis
- Arthritis
- Bursitis
- Carpal Tunnel Syndrome
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Doctors Specialties
- Rheumatology
- Internal Medicine
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Fellow
- Fellow (FACR)
Education
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University of California San Diego -
UCLA Medical Center -
Johns Hopkins University School of Medicine
Drug Facts
| NPI NUMBER | 1699790808 | |
| NPPES Provider LastName | FIRESTEIN | |
| NPPES Provider FirstName | GARY | |
| NPPES Provider ZIPCode | 921039001 | |
| NPPES Provider State | CA | |
| Specialty Description | Rheumatology | |
| Total Claim Count | 86.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1699790808 |
| Last Name Of The Provider | FIRESTEIN |
| First Name Of The Provider | GARY |
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