Chief of Surgery, Children's Hospital of Pittburgh
General Surgery
Dr. George K. Gittes, MD
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George K. Gittes works in the field of General Surgery. He studied medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School is ranked 1 in research and 12 in primary care medicine He received 5 awards: "America's Top Doctors", "Pittsburgh Magazine", "Elected Member", "Fellow (FAAP)" and "Fellow (FACS)". George Gittes is a published doctor as well. He has 100 publications published. The latest was: Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression.
Publications
- Intra-Islet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.
- Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors a...
- Barrier function of the coelomic epithelium in the developing pancreas.
- M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7.
- Pancreatic duct cells as a source of VEGF in mice.
- Specific transduction and labeling of pancreatic ducts by targeted recombinant viral infusion into mouse pancreatic ducts.
- α-Cells are dispensable in postnatal morphogenesis and maturation of mouse pancreatic islets.
- A smad signaling network regulates islet cell proliferation.
- Neurogenin3 Activation Is Not Sufficient to Direct Duct-to-Beta Cell Transdifferentiation in the Adult Pancreas.
- Smad signaling pathways regulate pancreatic endocrine development.
- A simplified purification method for AAV variant by polyethylene glycol aqueous two-phase partitioning.
- Hypoglycemia reduces vascular endothelial growth factor a production by pancreatic Beta cells as a regulator of Beta cell mass.
- TGF? Receptor Signaling Is Essential for Inflammation-Induced but Not ?-Cell Workload-Induced ?-Cell Proliferation.
- Rapid and simplified purification of recombinant adeno-associated virus.
- Three-Dimensional Analysis of the Islet Vasculature.
- Intestinal Epithelial Toll-like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice.
- Defective pulmonary innervation and autonomic imbalance in congenital diaphragmatic Hernia.
- Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice.
- Assessing vesicoureteral reflux in live inbred mice via ultrasound with a microbubble contrast agent.
- The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas.
- Embryonic mouse blood flow and oxygen correlate with early pancreatic differentiation.
- Impaired pancreatic development in Hif2-alpha deficient mice.
- Treatment of adolescent gynecomastia.
- Developmental biology of the pancreas: a comprehensive review.
- Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis.
- Clock controls timing of mouse pancreatic differentiation through regulation of Wnt- and Notch-based and cell division components.
- Maternal microchimerism in biliary atresia.
- TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas.
- Islet development: When glucagon's gone.
- The surgeon-scientist in a new biomedical research era.
- Faulty bone morphogenetic protein signaling in Esophageal atresia with tracheoEsophageal fistula.
- Relative value units correlate with pediatric surgeons' operating time: when perceived myth becomes reality.
- Urachal anomalies in children: the vanishing relevance of the preoperative voiding cystourethrogram.
- Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.
- Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas.
- Management of postoperative infections after the minimally invasive pectus excavatum repair.
- Management of complications after hypospadias repair.
- Interplay of glucagon-like peptide-1 and transforming growth factor-beta signaling in insulin-positive differentiation of AR42J cells.
- An effective pyloromyotomy length in infants undergoing laparoscopic pyloromyotomy.
- Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver.
- The impact of advances in developmental biology on the management of neonatal surgical anomalies.
- Multifaceted pancreatic mesenchymal control of epithelial lineage selection.
- Aberrant fibroblast growth factor receptor 2 signalling in Esophageal atresia with tracheoEsophageal fistula.
- Thyroglossal duct infections and surgical outcomes.
- Extracellular control of pancreatic differentiation.
- Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer.
- Defective sonic hedgehog signaling in Esophageal atresia with tracheoEsophageal fistula.
- Necrotizing enterocolitis in full-term infants.
- Evaluation of pectus bar position and osseous bone formation.
- Fibroblast growth factor signaling in the developing tracheoEsophageal fistula.
- Organogenesis particularly relevant to fetal surgery.
- Glucagon is required for early insulin-positive differentiation in the developing mouse pancreas.
- Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions.
- Complete discontinuity of the distal fistula tract from the developing gut: direct histologic evidence for the mechanism of tracheoEsophageal fistula formation.
- Thyroid transcription factor-1 expression in the human neonatal tracheoEsophageal fistula.
- Lectin as a marker for staining and purification of embryonic pancreatic epithelium.
- Minimally invasive repair of pectus excavatum: a single institution's experience.
- Semiquantitative polymerase chain reaction in RNase-producing tissues: Analysis of the developing pancreas.
- Minimally invasive bar repair for 'redo' correction of pectus excavatum.
- Onset of cell-specific gene expression in the developing mouse pancreas.
- Improvement in survival of mice with proximal small bowel obstruction treated with octreotide.
- The effect of ureteroperitoneostomy on renal mass in fasted rats.
- The effect of uretero-peritoneostomy on renal mass in rats with porto-caval shunts.
- Severe constipation with diffuse intestinal myenteric hyperganglionosis.
- Central venous catheter change over a guide wire: a simple technique.
- Calcitonin gene-related peptide (CGRP) upregulates the restitution of rat gastric mucosa in vitro.
- Studies of early events in pancreatic organogenesis.
- Mesenchymal epimorphin is important for pancreatic duct morphogenesis.
- Endocrine-committed progenitor cells retain their differentiation potential in the absence of neurogenin-3 expression.
- Multimedia article. Thoracoscopic patch repair of a right-sided congenital diaphragmatic Hernia in a neonate.
- Minimally invasive congenital diaphragmatic Hernia repair: a 7-year review of one institution''s experience.
- Diagnosis of ectopic ureter as a cause of urinary incontinence.
- Bone morphogenetic protein expression patterns in human Esophageal atresia with tracheoEsophageal fistula.
- Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis.
- A role for sonic hedgehog signaling in the pathogenesis of human tracheoEsophageal fistula.
- Pancreatic differentiation.
- Cross-talk between bone morphogenetic protein and transforming growth factor-beta signaling is essential for exendin-4-induced insulin-positive differentiation of AR42...
- Experience with laparoscopic adrenalectomy in pediatric patients.
- Retinoid signaling directs secondary lineage selection in pancreatic organogenesis.
- Somatostatin analogue therapy in functioning neuroendocrine gut tumors.
- Initiation of gastrin expression during the development of the mouse pancreas.
- A simplified method for mucosal proctectomy in children.
- Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors.
- Thal fundoplication in neurologically impaired children.
- Esophageal duplication cyst with Esophageal web and tracheoEsophageal fistula.
- Survival after necrotizing enterocolitis in infants weighing less than 1,000 g: 25 years' experience at a single institution.
- Efficacy of partial wrap fundoplication for gastroEsophageal reflux after repair of Esophageal atresia.
- In vitro prefabrication of human cartilage shapes using fibrin glue and human chondrocytes.
- Tamoxifen downregulates TGF-beta production in keloid fibroblasts.
- Inferior vena caval obstruction from a horseshoe kidney: report of a case with operative decompression.
- Scarless healing. The fetal wound.
- Glans approximation procedure urethroplasty for the wide, deep meatus.
- Immunolocalization of basic fibroblast growth factor and fibroblast growth factor receptor-1 and receptor-2 in rat cranial sutures.
- Rat mandibular distraction osteogenesis: Part I. Histologic and radiographic analysis.
- Signal transduction in wound pharmacology.
- Rat mandibular distraction osteogenesis: II. Molecular analysis of transforming growth factor beta-1 and osteocalcin gene expression.
- Esophageal atresia with tracheoEsophageal fistula: suggested mechanism in faulty organogenesis.
- Angiogenesis during mandibular distraction osteogenesis.
- Gene expression of insulin-like growth factors I and II in rat membranous osteotomy healing.
Schools
Harvard Medical School
Children Mercy Hospital
University Of California San Francisico School Of Medicine
Procedures Preformed
- Appendectomy, Laparoscopic
- Inguinal Hernia Repair, Open
Conditions Treated
- Appendicitis
- Esophageal Fistula
- Inguinal Hernia
Doctors Specialties
- Pediatric Surgery
- General Surgery
Accepted Insurances
Awards
- America's Top Doctors
- Pittsburgh Magazine
- Elected Member
- Fellow (FAAP)
- Fellow (FACS)
Education
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UCSF Medical Center -
Harvard Medical School
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