Physician
Neurology
Dr. George R. Uhl, MD
George is an expert in the field of Neurology. He studied medicine at Johns Hopkins University School of Medicine. Johns Hopkins University School of Medicine is a top medical university. Johns Hopkins University School of Medicine is ranked 3/29 in Research/PrimaryCare. He over the years received 1 awards: "Investigator Alumnus". George has written publications. He has 83 publications published with PubMed. The lastest publication is: 'Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice.'
Publications
- Functional Consequences of 17q21.31/WNT3-WNT9B Amplification in hPSCs with Respect to Neural Differentiation.
- Preface for addiction reviews.
- Agmatine attenuates methamphetamine-induced hyperlocomotion and stereotyped behavior in mice.
- Cell adhesion molecules: druggable targets for modulating the connectome and brain disorders?
- Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems.
- Reducing Aggression and Impulsivity Through School-Based Prevention Programs: A Gene by Intervention Interaction.
- Curious cases: Altered dose-response relationships in addiction genetics.
- Implications of genome wide association studies for addiction: Are our a priori assumptions all wrong?
- Preface to addiction reviews.
- Altered reward circuitry in the norepinephrine transporter knockout mouse.
- Evaluation of an HIV Prevention Intervention Designed for African American Women: Results from the SISTA Community-Based Organization Behavioral Outcomes Project.
- Biomarkers for Smoking Cessation.
- An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.
- Smoking quit success genotype score predicts quit success and distinct patterns of developmental involvement with common addictive substances.
- Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse.
- Active behaviours produced by antidepressants and opioids in the mouse tail suspension test.
- A single administration of methamphetamine to mice early in the light period decreases running wheel activity observed during the dark period.
- Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.
- Menthol Preference Among Smokers: Association With TRPA1 Variants.
- CHRNA3 rs1051730 Genotype and Short-term Smoking Cessation.
- Decreased response to social defeat stress in ?-opioid-receptor knockout mice.
- Histamine H(3) Receptor Agonists Decrease Hypothalamic Histamine Levels and Increase Stereotypical Biting in Mice Challenged with Methamphetamine.
- Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice.
- "Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.
- Genomic Regions Identified by Overlapping Clusters of Nominally-Positive SNPs from Genome-Wide Studies of Alcohol and Illegal Substance Dependence.
- "Replicated" genome wide association for dependence on illegal substances: Genomic regions identified by overlapping clusters of nominally positive SNPs.
- Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
- A human-specific de novo protein-coding gene associated with human brain functions.
- Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.
- Introduction to Addiction Reviews 2.
- Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
- Altered neurocircuitry in the dopamine transporter knockout mouse brain.
- Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes.
- Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion.
- Convergent genome wide association results for bipolar disorder and substance dependence.
- Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.
- Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm.
- Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers.
- Association of PTPRB gene polymorphism with drug addiction.
- Addiction Reviews. Preface.
- Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression.
- Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target ge...
- Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: Implications for drug dependence, toler...
- Brain-derived neurotrophic factor and obesity in the WAGR syndrome.
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
- Genome-wide association for methamphetamine dependence: convergent results from 2 samples.
- Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.
- Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis.
- Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions.
- Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals fro...
- Addiction molecular genetics: 639,401 SNP whole genome association identifies many "cell adhesion" genes.
- Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice.
- Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain.
- Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo.
- Molecular genetics of addiction vulnerability.
- Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sens...
- NrCAM in addiction vulnerability: positional cloning, drug-regulation, haplotype-specific expression, and altered drug reward in knockout mice.
- Molecular neurobiological methods in marijuana-cannabinoid research.
- Methods to study the behavioral effects and expression of CB2 cannabinoid receptor and its gene transcripts in the chronic mild stress model of depression.
- Behavioral methods in cannabinoid research.
- Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.
- Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease.
- Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain.
- Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters.
- Molecular mechanisms underlying the rewarding effects of cocaine.
- Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results.
- Food-reinforced operant behavior in dopamine transporter knockout mice: enhanced resistance to extinction.
- Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice.
- Setting priorities for genomic research.
- The burden of complex genetics in brain disorders.
- Dopamine transporter: basic science and human variation of a key molecule for dopaminergic function, locomotion, and parkinsonism.
- Reduced behavioral effects of cocaine in heterozygous brain-derived neurotrophic factor (BDNF) knockout mice.
- Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites.
- Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities.
- Effects of acute "binge" cocaine on preprodynorphin, preproenkephalin, proopiomelanocortin, and corticotropin-releasing hormone receptor mRNA levels in the s...
- Brain imaging to assess the effects of dopamine agonists on progression of Parkinson disease.
- KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine.
- Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism.
- Pretreatment or Posttreatment with Aripiprazole Attenuates Methamphetamine-induced Stereotyped Behavior in Mice.
- Serotonin/Dopamine Interactions in a Hyperactive Mouse: Reduced Serotonin Receptor 1B Activity Reverses Effects of Dopamine Transporter Knockout.
- Involvement of the Neutral Amino Acid Transporter SLC6A15 and Leucine in Obesity-Related Phenotypes.
Schools
Johns Hopkins University School of Medicine
Stanford University Hospital
Johns Hopkins Hospital
Doctors Specialties
- Neurology
Accepted Insurances
Awards
- Investigator Alumnus
Education
-
Johns Hopkins University -
Stanford University -
Johns Hopkins University School of Medicine
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