Associate Professor of Medicine, Massachusetts General Hospital

Internal Medicine

Gino V. Segre works in the field of Internal Medicine. He graduated from Weill Cornell Medical College of Cornell University. Weill Cornell Medical College of Cornell University has a rank of 18 in research and a 49 in primary care Gino Segre is also a published doctor. He has 101 paper published. The most recent paper is: Proceedings: Linear and non-linear kinetics in human pharmacokinetics.

Publications

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• G{alpha}q Signal in Osteoblasts Is Inhibitory to the Osteoanabolic Action of Parathyroid Hormone.
• Continuous activation of G alpha q in osteoblasts results in osteopenia through impaired osteoblast differentiation.
• The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain sma...
• Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellu...
• Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kid...
• Purification and characterization of a receptor for human parathyroid hormone and parathyroid hormone-related peptide.
• [Calculation of the pulmonary transfer function from radiocardiographic data].
• The precursor-product relationship.
• A comparison of activity of quinine and quinidine on the isolated electrically stimulated rat ventricle strip.
• [Importance of potassium ion in protein synthesis].
• [Influence of pH on the equilibrium constant of pharmacological reactions].
• pH-dependant action of NaCI on isolated guinea pig''s ileum.
• [Stimulating and aspecific inhibitory actions of various proteins on the isolated guinea pig ileum, as a function of pH].
• DETERMINATION OF THE PULMONARY WEIGHTING FUNCTION, OF THE MEAN PULMONARY TRANSIT TIME AND OF THE PULMONARY BLOOD VOLUME IN MAN BY MEANS OF RADIOCARDIOGRAMS.
• [MODE OF DIVISION FOR BILIARY ELIMINATION OF BROMOSULFONPHTHALEIN].
• [BLOOD KINETICS OF DIBROMOSULFONPHTHALEIN AND TETRABROMOSULFONPHTHALEIN IN CARBON TETRACHLORIDE POISONING].
• [ASPECTS OF GLUCOSE KINETICS IN DIABETICS].
• Analysis of synergisms in chemotherapy.
• [Research on the human pulmonary circulation by means of cardiac catheterization and radioactive tracers].
• [Aspecific actions depending upon the pH of various amino acids].
• Applications of the transfer functions to pharmacology.
• [Pharmacokinetic periodism].
• [Competitive antagonism of an aspecific nature in certain pharmacological reactions in vitro].
• [Aspecific action of histidine on the isolated intestine, in relation to pH].
• [Action of quinidine and procaine amide on the isolated rat ventricle].
• [Thermodynamics of histamine-induced contractions of the isolated guinea pig ileum].
• Distribution of the parathyroid hormone 2 receptor in rat: immunolocalization reveals expression by several endocrine cells.
• Amiloride pharmacokinetics in rat.
• Effect of ouabain on the kinetics of ATP hydrolysis in the guinea pig heart.
• [Bioavailability of 2 different depot formulations with 40 mg of isosorbide dinitrate].
• Pharmacokinetics of lonidamine.
• Gas chromatographic determination of paracetamol in plasma.
• [Serum kinetics and biotransformation of prostenoglycine in the rat, dog and monkey].
• Pharmacokinetics of fentiazac in rats and monkeys.
• [Pharmacokinetic aspects relevant to biopharmaceutics].
• Pharmacokinetics--compartmental representation.
• Plasma kinetics of dihydroergotoxin in rat by using a radioreceptor assay.
• Kinetic analysis of the response of plasma glucose, insulin, and C-peptide to glucagon injection in normal and diabetic subjects.
• Expression of parathyroid hormone receptors in MDCK and LLC-PK1 cells.
• Metabolic effects of carbocalcitonin and salmon calcitonin, after endonasal administration in man.
• [The pharmacokinetics of antibiotics: parenteral and oral administration, distribution in the organism, elimination].
• Risk factors for renal osteodystrophy: a multivariant analysis.
• [Glutathione-S-transferase and glutathione in the liver and blood of rats poisoned by thioacetamide].
• o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents.
• Renal osteodystrophy in diabetic patients.
• Renal bone disease in pediatric and young adult patients on hemodialysis in a children's hospital.
• The aplastic form of renal osteodystrophy.
• Pharmacological activity of epinephrine bound to glass beads.
• Femtogram determination of ACTH by bioradioimmunoassay.
• [Problems in determination of glutathione in rat liver supernatant].
• Relation between morphine pharmacokinetics and analgesia.
• Simultaneous determination of di-n-propylacetic acid and ethosuximide in plasma by gas liquid chromatography.
• The effect of clonidine, triamterene, and amiloride on pharmacokinetics and cardiotoxicity of ouabain in rabbits.
• [Hepatic glutathione content in rats with carbon tetrachloride poisoning].
• Multicompartmental analysis of serum, urine and bile concentrations of rifampicin and desacetyl-rifampicin in subjects treated for one week.
• Ligandin release from liver into blood in rats intoxicated by carbon tetrachloride.
• [Liver glutathione and ligandin in carbon tetrachloride poisoning].
• Ligandin content in liver of rats intoxicated by a carbon tetrachloride.
• [Antibiotics in dentistry].
• Proceedings: Linear and non-linear kinetics in human pharmacokinetics.
• A method to improve pharmacokinetic analysis in small animals.
• [Binding and enzyme activity of ligandins in rats with carbon tetrachloride poisoning].
• [Gas-chromatographic determination in pharmaceutic preparations and in biological samples and the pharmacokinetics of 2-phenyl-dimethyl-1,4-tetrahydroxazine in rats].
• Proceedings: Kinetics of rifampicin and desacetyl-rifampicin in plasma, bile, and urine in humans and the effect of repeated administrations.
• Pharmacokinetics of rufloxacin in healthy volunteers.
• [Linear and non linear models of the kinetics of biliotropic contrast media].
• [Renal clearance of rufloxacin in the healthy volunteer].
• Pharmacokinetics of pramiracetam in healthy volunteers after oral administration.
• Pharmacokinetics of heptastigmine in rats.
• Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.
• Non-invasive prediction of aluminum bone disease in hemo- and peritoneal dialysis patients.
• Plasma kinetics of atropine and ipratropium in rats after different routes of administration evaluated by a radioreceptor assay.
• The sojourn time and its use in pharmacology.
• Influence of probenecid on P-amino hippurate kinetics.
• Inhibition of ornithine-decarboxylase produced by S(+) and R(-) ibuprofen in rats.
• Triazolam pharmacokinetics in rats using a radioreceptor assay.
• Plasma ACTH levels in buspirone-treated rats.
• Antagonism of aminoglutethimide and adrenocorticotropic hormone (ACTH) studied on slices of adrenal glands of the guinea-pig.
• Pharmacokinetics of bamifylline during chronic therapy.
• A program in BASIC for calculating randomization tests.
• Antiasthmatic drugs--opening remarks.
• Recovery of immunological cutaneous responsiveness in the acquired immune deficiency syndrome following treatment with papaverine.
• Glutathione (GSH) in human stomach mucosa.
• [Pharmacological aspects of glucosaminoglycans].
• Effect of ACTH, beta-endorphin, morphine and naloxone on the release of cortisol by isolated adrenal glands.
• Effect of morphine and naloxone on the levels of ACTH and beta-endorphin in plasma, brain and pituitary of rats.
• Effect of S-adenosyl-L-methionine on the gastric ulcer in rats.
• High-pressure liquid chromatographic (HPLC) determination of indomethacin in plasma.
• A new tricyclic fluoroquinolone, rufloxacin (MF-934), with interesting antibacterial and pharmacokinetic characteristics.
• The sojourn time and its prospective use in pharmacology.
• Serum and urine kinetics of rosaprostol in volunteers.
• Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man.
• Pharmacokinetics of flunoxaprofen in rats, dogs, and monkeys.
• Pharmacokinetic profile of fosfomycin trometamol (Monuril).
• Fractures and vertebral bone mineral density in patients with renal osteodystrophy.
• Flunoxaprofen pharmacokinetics in elderly subjects.
• Thiazolidine-4-carboxylic acid toxicity and glutathione levels in various organs of the rat.
• The kinetics in the rat of a new nitroimidazole derivative.
• Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.
• Pharmacokinetics of flunitrazepam in rats studied by a radioreceptor assay.

Schools

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• Weill Cornell Medical College

• Johns Hopkins Hospital

• Palo Alto Stanford Hospital Center

• Massachusetts General Hospital

Doctors Specialties

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• Internal Medicine

Accepted Insurances

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Education

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• Massachusetts General Hospital
• Stanford University
• Johns Hopkins University
• Weill Cornell Medical College of Cornell University

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