Professor of Pediatrics, Professor of Radiation Oncology and Molecular Radiation Sciences, Professor of Biological Chemistry, Professor of Medicine, Professor of Oncology, Johns Hopkins University School of Medicine; Director, Vascular Program, Institute
Medical Genetics
Dr. Gregg Semenza, MD
Gregg Semenza, MD is an expert in the field of Medical Genetics. He went to Perelman School of Medicine at the University of Pennsylvania. He over the years received 1 awards: "Elected Member". Gregg Semenza is a published doctor. He has 32 papers published. The most current publication "Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA."
Publications
- Introduction to tumor microenvironment regulation of cancer cell survival, metastasis, inflammation, and immune surveillance.
- Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea.
- Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors.
- HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
- Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
- Hypoxia-inducible factor 1 and breast cancer metastasis.
- Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.
- Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer.
- PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility.
- Regulation of Hypoxia Inducible Factor-α Isoforms and Redox State By Carotid Body Neural Activity in Rats.
- Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
- Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
- Hypoxia and the extracellular matrix: drivers of tumour metastasis.
- Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
- Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negat...
- Role of hypoxia-inducible factors in breast cancer metastasis.
- Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart.
- Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
- Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis.
- VEGF Secreted by Hypoxic Muller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retino...
- Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
- Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.
- Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1.
- Advances in cancer biology and therapy.
- Blood vessels, disease pathogenesis, and novel therapies.
- A Nontranscriptional Role for HIF-1? as a Direct Inhibitor of DNA Replication.
- Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
- Emerging roles of PKM2 in cell metabolism and cancer progression.
- Analysis of hypoxia-induced metabolic reprogramming.
- HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase.
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA.
Schools
Perelman School of Medicine University of Pennsylvania
Duke University Med Center
Johns Hopkins Hospital
Doctors Specialties
- Clinical Genetics
- Pediatrics
- Medical Genetics
Accepted Insurances
- Southern Health PPO
- First Health (Coventry Health Care) PPO
- MultiPlan PPO
- PHCS Network PPO
Awards
- Elected Member
Education
-
Johns Hopkins University -
Duke University Hospital -
Perelman School of Medicine at the University of Pennsylvania
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