Professor, Medicine, UCLA School of Medicine
Endocrinology
Dr. Gregory A. Brent, MD
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Dr. Gregory A. Brent practices Endocrinology. He studied medicine at Keck School of Medicine of USC. Keck School of Medicine of USC is ranked 31 in research and 72 in primary care medicine He received awards:"Elected Member". Dr. Gregory A. Brent has written publications. He has 100 publications published with PubMed. The lastest publication is: 'Mechanisms of thyroid hormone action. Implications for the clinical manifestation of thyrotoxicosis.'
Publications
- Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.
- A review: Radiographic iodinated contrast media-induced thyroid Dysfunction.
- Thyrotoxicosis of Pregnancy.
- Perchlorate Exposure in Pregnancy and Cognitive Outcomes in Children: It's Not Your Mother's Thyroid.
- Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism.
- Updates on the management of Diabetes in dialysis patients.
- Thyroid functional Disease: an under-recognized cardiovascular risk factor in kidney Disease patients.
- Children of mothers with iodine deficiency during pregnancy are more likely to have lower verbal IQ and reading scores at 8-9 years of age.
- Cancer: Novel target to enhance radioiodine uptake in thyroid cancer.
- Regulation of sodium iodide symporter gene expression by the Rac1/p38? MAP kinase signaling pathway in MCF-7 breast cancer cells.
- Management of Hypothyroidism in pregnancy.
- Publication of industry-sponsored medical research: guidelines from the consortium of laboratory medicine journal editors.
- Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.
- Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8).
- Environmental exposures and autoimmune thyroid Disease.
- The impact of perchlorate exposure in early pregnancy: is it safe to drink the water?
- Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation.
- Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.
- Activation of the PI3 kinase pathway by retinoic acid mediates sodium/iodide symporter induction and iodide transport in MCF-7 breast cancer cells.
- Clinical practice. Graves' Disease.
- Stealth sequences in reporter gene vectors confound studies of T3-regulated negative gene expression.
- Retinoic acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is mediated by the insulin growth factor-I/phosphatidylinositol 3-kinase and p38 ...
- Thyroid health and the environment.
- A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation.
- Diagnosing thyroid Dysfunction in pregnant women: Is case finding enough?
- Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.
- Anaplastic thyroid carcinoma with thyrotoxicosis and hypoparathyroidism.
- Differential regulation of sodium/iodide symporter gene expression by nuclear receptor ligands in MCF-7 breast cancer cells.
- Rapid progression from subclinical to symptomatic overt Hypothyroidism.
- Resistance to thyroid hormone in Hashimoto's thyroiditis.
- Thyroid hormone-dependent gene expression in differentiated embryonic stem cells and embryonal carcinoma cells: identification of novel thyroid hormone target genes by...
- Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter.
- Systemic retinoic acid treatment induces sodium/iodide symporter expression and radioiodide uptake in mouse breast cancer models.
- Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1.
- A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice.
- Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells.
- Follow-up of newborns with elevated screening T4 concentrations.
- Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells.
- A complex deoxyribonucleic acid response element in the rat Ca(2+)/calmodulin-dependent protein kinase IV gene 5'-flanking region mediates thyroid hormone induction an...
- A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-lik...
- Thyroid hormone gene targets in ROS 17/2.8 osteoblast-like cells identified by differential display analysis.
- A targeted thyroid hormone receptor alpha gene dominant-negative mutation (P398H) selectively impairs gene expression in differentiated embryonic stem cells.
- Nonthyroidal illness syndrome: evaluation of thyroid function in sick patients.
- A GC box in the human sodium iodide symporter gene promoter is essential for full activity.
- Phosphoinositide-3-kinase inhibition induces sodium/iodide symporter expression in rat thyroid cells and human papillary thyroid cancer cells.
- The modified firefly luciferase reporter gene (luc+) but not Renilla luciferase is induced by all-trans retinoic acid in MCF-7 breast cancer cells.
- Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements.
- Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation.
- Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.
- Thyroid hormone receptor gene knockouts.
- Differential capacity of wild Type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors.
- Specificity of nuclear hormone receptor action: who conducts the orchestra?
- Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild Type T3 response elements.
- Oligomeric binding of T3 receptor is required for maximal T3 response.
- Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3...
- Thyroid hormone: half-sites and insights. Molecular Approaches to the Study of Thyroid hormone Action: a Keystone Symposium, Tamarron, CO, USA, March 8-14, 1991.
- Thyroid hormone regulation of gene expression.
- Direct repeats.
- Increased need for thyroxine during pregnancy in women with primary Hypothyroidism.
- Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing.
- Adrenocorticotropin stimulation of aldosterone: prolonged continuous versus pulsatile infusion.
- Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor.
- Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element.
- Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glu...
- Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor.
- Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta Type thyroid h...
- Reversible alteration of red cell lithium-sodium countertransport in patients with thyroid Disease.
- Thyroxine therapy in patients with severe nonthyroidal illnesses and low serum thyroxine concentration.
- Relationship between the concentration and rate of change of calcium and serum intact parathyroid hormone levels in normal humans.
- Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.
- Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range.
- The partitioning of delta 1-tetrahydrocannabinol into erythrocyte membranes in vivo and its effect on membrane fluidity.
- Serum angiotensin-converting enzyme in severe nonthyroidal illnesses associated with low serum thyroxine concentration.
- Auditory averaged evoked potentials and aging: factors of stimulus, task and topography.
- Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis.
- Prospective studies of thyroid function in patients receiving gold therapy.
- Retinoid-X receptor (RXR) differentially augments thyroid hormone response in cell lines as a function of the response element and endogenous RXR content.
- Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem ...
- The molecular basis of thyroid hormone action.
- Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement.
- Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.
- Levothyroxine therapy in patients with thyroid Disease.
- Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor.
- Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness.
- Maternal thyroid function: interpretation of thyroid function tests in pregnancy.
- Mechanisms of thyroid hormone action. Implications for the clinical manifestation of thyrotoxicosis.
- Thyroid hormone action: down novel paths. Focus on "thyroid hormone induces activation of mitogen-activated protein kinase in cultured cells".
- Maternal Hypothyroidism: recognition and management.
- Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line.
- Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor.
- Induction of follicle formation in long-term cultured normal human thyroid cells treated with thyrotropin stimulates iodide uptake but not sodium/iodide symporter mess...
- Regulation of prohormone convertase 1 (PC1) by thyroid hormone.
- Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific.
- Differential regulation of the human sodium/iodide symporter gene promoter in papillary thyroid carcinoma cell lines and normal thyroid cells.
- Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms.
- Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer.
- Tissue-specific actions of thyroid hormone: insights from animal models.
- The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response el...
- Introduction. The impact of maternal thyroid Diseases on the developing fetus: implications for diagnosis, treatment, and screening. Summary of proceedings, workshop o...
Schools
University of Southern California Keck School of Medicine
Wadsworth Va Ucla
Brigham Womens Hospital
Conditions Treated
- Diabetes Type 2
- Goiter
- Graves' Disease
- Hyperlipidemia
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Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Brigham and Women's Hospital -
VA Greater Los Angeles Healthcare System -
Keck School of Medicine of USC
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