Professor, Medicine, UCSF School of Medicine
Pulmonology
Dr. Harold A. Chapman Jr., MD
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Harold Chapman practices Pulmonology. He researched medicine at University of Alabama School of Medicine. University of Alabama School of Medicine is ranked 37/17 in Research/PrimaryCare. He has 2 awards "Elected Member" and "Super Doctor". Harold Chapman is a published physician as well. He has 100 publications published. The latest was: Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. He is registered with Medicare and accepts Medicare payments.
Publications
- Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling.
- Lineage-negative progenitors mobilize to regenerate Lung epithelium after major injury.
- Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia.
- BPIFB1 is a Lung-specific autoantigen associated with interstitial Lung disease.
- Future Directions in Idiopathic Pulmonary Fibrosis Research: An NHLBI Workshop Report.
- Activated Alveolar Epithelial Cells Initiate Fibrosis through Secretion of Mesenchymal Proteins.
- Inhibition of Epithelial to Mesenchymal Transition and Pulmonary Fibrosis by Methacycline.
- Cell Therapy for Lung Diseases: Report from an NIH-NHLBI Workshop November 13-14, 2012.
- Molecular determinants of Lung development.
- Regenerative Activity of the Lung after Epithelial Injury.
- Epithelial responses to Lung injury: role of the extracellular matrix.
- Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors.
- Axin Pathway Activity Regulates in Vivo pY654-?-catenin Accumulation and Pulmonary Fibrosis.
- Integrin ?6?4 identifies an adult distal Lung epithelial population with regenerative potential in mice.
- Cell Plasticity in Lung injury and repair: report from an NHLBI workshop, April 19-20, 2010.
- Toward Lung regeneration.
- Alveolar Epithelial Cells Express Mesenchymal Proteins in Patients With Idiopathic Pulmonary Fibrosis.
- Epithelial-mesenchymal interactions in Pulmonary fibrosis.
- Urokinase receptor mediates Lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins.
- Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts.
- Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and Pulmonary fibrosis.
- Endothelin-1 as initiator of epithelial-mesenchymal transition: potential new role for endothelin-1 during Pulmonary fibrosis.
- Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells.
- Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.
- Alveolar epithelial cell mesenchymal transition develops in vivo during Pulmonary fibrosis and is regulated by the extracellular matrix.
- The SERPINE2 gene is associated with chronic obstructive Pulmonary disease.
- Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways.
- Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors.
- Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease.
- A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive Pulmonary disease.
- Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and Pulmonary emphysema.
- Transient role for CD1d-restricted natural killer T cells in the formation of atherosclerotic lesions.
- Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice.
- Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis.
- Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.
- Genome-wide linkage of forced mid-expiratory flow in chronic obstructive Pulmonary disease.
- Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice.
- Cathepsins as transcriptional activators?
- Proteases, extracellular matrix, and cancer: a workshop of the path B study section.
- Disorders of Lung matrix remodeling.
- Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact.
- Matrilysin-dependent elastolysis by human macrophages.
- The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune di...
- Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.
- The mechanism underlying T cell help for induction of an antigen-specific in vivo humoral immune response to intact Streptococcus Pneumoniae is dependent on the type o...
- Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive Pulmonary disease.
- Adenovirally mediated expression of urokinase receptor binding site on integrin alpha-chain blocks adhesion and migration of human Lung fibroblasts.
- Subthalamic nucleus neurones in slices from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice show irregular, dopamine-reversible firing pattern changes, but ...
- Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
- The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson''s disease through inhibition of monoamine oxidase B.
- Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice.
- Modulation of macrophage tumoricidal capability by polyene antibiotics: support for membrane lipid as a regulatory determinant of macrophage function.
- DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with Pulmonary tuberculosis risk in West Africans.
- v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle...
- Ontogeny of Peyer''s patches and immunoglobulin-containing cells in pigs.
- A fibrinolytic inhibitor of human alveolar macrophages. Induction with endotoxin.
- Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for per...
- Homozygosity for a HERG potassium channel mutation causes a severe form of long QT syndrome: identification of an apparent founder mutation in the Finns.
- A founder mutation of the potassium channel KCNQ1 in long QT syndrome: implications for estimation of disease prevalence and molecular diagnostics.
- Co-operation between plasmin and elastase in elastin degradation by intact murine macrophages.
- Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid.
- Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial Lung disease.
- Characterization of the effects of endotoxin on macrophage tumor cell killing.
- Characterization of a macrophage-derived plasminogen-activator inhibitor. Similarities with placental urokinase inhibitor.
- Human alveolar macrophages synthesize factor VII in vitro. Possible role in interstitial Lung disease.
- Elastinolytic activity of human cathepsin L.
- Macrophage fibrinolytic activity: identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor.
- Structure and chromosomal assignment of the human cathepsin K gene.
- Expression of cathepsins B and S in the progression of prostate carcinoma.
- Comparison of live human neutrophil and alveolar macrophage elastolytic activity in vitro. Relative resistance of macrophage elastolytic activity to serum and alveolar...
- Role of enzyme receptors and inhibitors in regulating proteolytic activities of macrophages.
- Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential.
- Coordinate expression of macrophage procoagulant and fibrinolytic activity in vitro and in vivo.
- Alveolar macrophage urokinase receptors localize enzyme activity to the cell surface.
- In vitro assay of extracellular matrix elastin degradation.
- Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of a plasminogen activator and its role in matrix degradation.
- Depressed bronchoalveolar urokinase activity in patients with adult Respiratory distress syndrome.
- Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
- Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleav...
- Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
- Importance of lysosomal cysteine proteases in Lung disease.
- Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.
- Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration.
- Developmental expression of plasminogen activator inhibitor type 1 by human alveolar macrophages. Possible role in Lung injury.
- Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.
- An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines.
- Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors.
- Role of enzymes mediating thrombosis and thrombolysis in Lung disease.
- Endosomal proteolysis and MHC class II function.
- Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L.
- Identification of cystatin C, a cysteine proteinase inhibitor, as a major secretory product of human alveolar macrophages in vitro.
- Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.
- Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization.
- Synthesis and processing of cathepsin L, an elastase, by human alveolar macrophages.
- Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.
- Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
- Role of plasminogen activator in degradation of extracellular matrix protein by live human alveolar macrophages.
- Genetic epidemiology of severe, early-onset chronic obstructive Pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis.
- A Fas pathway to Pulmonary fibrosis.
Schools
University of Alabama At Birmingham
Procedures Preformed
- Bronchoscopy
Conditions Treated
- Acidosis
- Asthma
- Atelectasis
- Bronchiectasis
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Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
Awards
- Elected Member
- Super Doctor
Education
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University of Utah -
University of Alabama School of Medicine
Hospital
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San Francisco General Hospital and Trauma Center -
UCSF Medical Center
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