Physician
Internal Medicine
Dr. Haven T. Spencer, MD
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Haven Spencer is an expert in the field of Internal Medicine. He went to medical school at Boston University School of Medicine. Boston University School of Medicine has a rank of 30 in research and a 52 in primary care He received awards:"Patient-Centered Medical Home Recognition Program" and "Physician Practice Connections Recognition Program". Haven Spencer is a published doctor as well. He has 32 publications published. The latest was: A structural role for glutamine 214 in human thymidylate synthase.
Publications
- High-throughput screening identifies compounds that enhance lentiviral transduction.
- Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.
- Engineered drug-resistant immunocompetent cells enhance tumor cell killing during a chemotherapy challenge.
- Advancements in gene transfer-based therapy for hemophilia A.
- Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.
- Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A.
- Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells.
- Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens.
- Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity.
- Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.
- High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells.
- Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus.
- Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
- Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
- Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
- Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
- Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.
- Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.
- Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation.
- Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.
- A structural role for glutamine 214 in human thymidylate synthase.
- Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.
- Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
- Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors.
- A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs.
- Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady...
- A gene transfer strategy for making bone marrow cells resistant to trimetrexate.
- Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
- Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate.
- Use of 10-propargyl-5,8-dideazafolate and directed mutagenesis to probe the catalytic mechanism of thymidylate synthase.
- Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
Schools
Boston University School Of Medicine
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Patient-Centered Medical Home Recognition Program
- Physician Practice Connections Recognition Program
Education
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Boston University School of Medicine
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