Professor, Psychiatry, Perelman School of Medicine
Psychiatry
Dr. Henry R. Kranzler, MD
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Henry R. Kranzler, MD works in the field of Psychiatry. He went to medical school at Rutgers Robert Wood Johnson Medical School. Rutgers Robert Wood Johnson Medical School is ranked 74 in research and 67 in primary care medicine Henry R. Kranzler, MD is also published. He has 98 publications published. The lastest publication: "Balancing risk and benefit in heavy drinkers treated with topiramate: implications for personalized care.'
Publications
- Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Co...
- Balancing risk and benefit in heavy drinkers treated with topiramate: implications for personalized care.
- Insomnia in alcohol dependent subjects is associated with greater psychosocial problem severity.
- Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
- Genome-wide association study of copy number variations (CNVs) with opioid dependence.
- Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.
- Posttreatment effects of topiramate treatment for heavy drinking.
- What happens when people discontinue taking medications? Lessons from COMBINE.
- FKBP5 variation is associated with the acute and chronic effects of nicotine.
- Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking.
- GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate.
- The Joint Effects of ADH1B Variants and Childhood Adversity on Alcohol Related Phenotypes in African-American and European-American Women and Men.
- Methods to analyze treatment effects in the presence of missing data for a continuous heavy drinking outcome measure when participants drop out from treatment in alcoh...
- Topiramate's reduction of body mass index in heavy drinkers: Lack of moderation by a GRIK1 polymorphism.
- Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Depen...
- Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.
- Identification of methylation quantitative trait loci (mQTLs) influencing promoter DNA methylation of alcohol dependence risk genes.
- Translating the Semi-Structured Assessment for Drug Dependence and Alcoholism in the Western Pacific: Rationale, Study Design and Reliability of Alcohol Dependence.
- Characteristics and course of dependence in cocaine-dependent individuals who never used alcohol or marijuana or used cocaine first.
- Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3α-HSD type 2 (17β-HSD type 5), moderates the subjective effects of alcohol.
- GRIK1 Genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink.
- Risks of alcohol use disorders related to drinking patterns in the u.s. General population.
- The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders.
- Pharmacotherapy of alcohol use disorders: seventy-five years of progress.
- Cumulative Proportion of Responders Analysis (CPRA) as a Tool to Assess Treatment Outcome in Alcohol Clinical Trials.
- Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment.
- Rate of progression from first use to dependence on cocaine or opioids: A cross-substance examination of associated demographic, psychiatric, and childhood risk factors.
- Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis.
- Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.
- An Interpersonal Model of Addiction Relapse.
- Associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
- Integrating GWASs and Human Protein Interaction Networks Identifies a Gene Subnetwork Underlying Alcohol Dependence.
- Association of Gamma-Aminobutyric Acid A Receptor α 2 Gene (GABRA2) with Alcohol Use Disorder.
- A GABRA2 Variant Is Associated with Increased Stimulation and 'High' Following Alcohol Administration.
- Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
- Topiramate for Smoking Cessation: A Randomized, Placebo-Controlled, Pilot Study.
- Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.
- Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
- Insomnia in alcohol dependence: predictors of symptoms in a sample of veterans referred from primary care.
- Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder.
- Ordered subset linkage analysis based on admixture proportion identifies new linkage evidence for alcohol dependence in African-Americans.
- Effects of the 2011 duty hour reforms on interns and their patients: a prospective longitudinal cohort study.
- Circadian Clock Period Inversely Correlates with Illness Severity in Cells from Patients with Alcohol Use Disorders.
- Major Depression and PTSD in Pregnant Smokers Enrolled in Nicotine Gum Treatment Trial.
- Array-based profiling of DNA methylation changes associated with alcohol dependence.
- 5-HTTLPR genotype and daily negative mood moderate the effects of sertraline on drinking intensity.
- Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample.
- Personalized Treatment of Alcohol Dependence.
- Variation in OPRM1 moderates the effect of desire to drink on subsequent drinking and its attenuation by naltrexone treatment.
- GABRA2 markers moderate the subjective effects of alcohol.
- The 5-HTTLPR polymorphism moderates the effect of stressful life events on drinking behavior in college students of African descent.
- Variation in???OPRM1???and Risk of Suicidal Behavior in Drug-Dependent Individuals.
- M3: An Improved SNP Calling Algorithm for Illumina BeadArray Data.
- A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women.
- Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with ?5 Nicotinic Acetylcholine Receptor Genotype Specifically in Males.
- Post-Treatment Outcomes in a Double-Blind, Randomized Trial of Sertraline for Alcohol Dependence.
- Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q.
- GABRG1 and GABRA2 Variation Associated with Alcohol Dependence in African Americans.
- The Alcohol Clinical Trials Initiative (ACTIVE): Purpose and Goals for Assessing Important and Salient Issues for Medications Development in Alcohol Use Disorders.
- Comparison of Alcoholism Subtypes as Moderators of the Response to Sertraline Treatment.
- A Genomewide Linkage Scan of Cocaine Dependence and Major Depressive Episode in Two Populations.
- Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence.
- Association between polymorphisms in catechol-O-methyltransferase (COMT) and cocaine-induced paranoia in European-American and African-American populations.
- Variation in NGFB is associated with primary affective disorders in women.
- Association of CHRNA4 polymorphisms with smoking behavior in two populations.
- Empirically derived subtypes of opioid use and related behaviors.
- Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence.
- 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder.
- A double-blind, randomized trial of sertraline for alcohol dependence: moderation by age and 5-hydroxytryptamine transporter-linked promoter region genotype.
- Agitated depression in substance dependence.
- ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure.
- Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics.
- Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility.
- Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.
- Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.
- A prospective cohort study investigating factors associated with depression during medical internship.
- Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.
- Confirmation and generalization of an alcohol-dependence locus on chromosome 10q.
- ADH1A variation predisposes to personality traits and substance dependence.
- Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men.
- Comparison of healthcare utilization among patients treated with alcoholism medications.
- Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
- Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use.
- Measurement of admixture proportions and description of admixture structure in different U.S. populations.
- Targeted naltrexone for problem drinkers.
- Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
- Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and populatio...
- Sources of unreliability in the diagnosis of substance dependence.
- A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors.
- Association of variants in MANEA with cocaine-related behaviors.
- Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10.
- A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students.
- Nicotine gum for pregnant smokers: a randomized controlled trial.
- Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue.
- ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.
- Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.
- Acamprosate efficacy in alcohol-dependent patients: summary of results from three pivotal trials.
Schools
University of Medicine And Dentistry of New Jersey Robert Wood Johnson Medical School
Hartford Hospital
University Conn Health Center
Doctors Specialties
- Addiction Psychiatry
- Psychiatry
Accepted Insurances
Education
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University of Connecticut -
Rutgers Robert Wood Johnson Medical School
Hospital
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Hospital of the University of Pennsylvania -
Philadelphia Veterans Affairs Medical Center -
Penn Presbyterian Medical Center
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