Vice Chancellor for Health Affairs Dean, School of Medicine University of California at Irvine Irvine, California
Internal Medicine
Dr. Howard J. Federoff, MD
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Howard Federoff practices Internal Medicine. He went to Albert Einstein College of Medicine of Yeshiva University. He received 1 awards: "Fellow". Dr. Howard J. Federoff is also a published physician. He has 101 publication published. The most recent publication is: Perspectives on best practices for gene therapy programs.
Publications
- Perspectives on best practices for gene therapy programs.
- The critical need for defining preclinical biomarkers in Alzheimer's disease.
- Gene Therapy: Charting a Future Course Summary of a National Institutes of Health Workshop, April 12, 2013.
- Plasma phospholipids identify antecedent memory impairment in older adults.
- Development of Inducible Leucine-rich Repeat Kinase 2 (LRRK2) Cell Lines for Therapeutics Development in Parkinson's Disease.
- Using viral-mediated gene delivery to model Parkinson's disease: Do nonhuman primate investigations expand our understanding?
- Microglial Activation and Antioxidant Responses Induced by the Parkinson's Disease Protein ?-Synuclein.
- Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density.
- Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord.
- Disclosure of clinical trial results when product development is abandoned.
- Characterization of nectin processing mediated by presenilin-dependent γ-secretase.
- Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease.
- Trk retrograde signaling requires persistent, Pincher-directed endosomes.
- Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System.
- Technology and innovation: 2010 a year in review.
- A new research and development policy framework for the biomedical research enterprise.
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
- Georgetown University School of Medicine.
- Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
- Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).
- Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF.
- The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.
- Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys.
- Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease.
- Death in a gene-therapy trial.
- Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease.
- Mutant alpha-synuclein overexpression mediates early proinflammatory activity.
- Evolving from reductionism to holism: is there a future for systems medicine?
- Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases.
- Real-time MR imaging of adeno-associated viral vector delivery to the primate brain.
- Development of vaccination approaches for the treatment of neurological diseases.
- HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
- Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys.
- Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys.
- Immune responses to herpesviral vectors.
- Effects of herpes simplex virus amplicon transduction on murine dendritic cells.
- HSV ICP0 recruits USP7 to modulate TLR-mediated innate response.
- Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice.
- Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium.
- Synuclein activates microglia in a model of Parkinson's disease.
- Identification of a novel nurr1-interacting protein.
- Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
- Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons.
- Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4.
- Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.
- CNS delivery of vectored prion-specific single-chain antibodies delays disease onset.
- The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes.
- Gazing into the future: Parkinson's disease gene therapeutics to modify natural history.
- Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity i...
- Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition.
- Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.
- In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1alpha function regardless of the presence of DNA damage.
- Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.
- Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene.
- Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors.
- VIP is a transcriptional target of Nurr1 in dopaminergic cells.
- Identification of human alpha-synuclein specific single chain antibodies.
- Microarrays in Parkinson's disease: a systematic approach.
- Systems biology: a primer.
- Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons.
- Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector.
- Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal...
- Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease.
- CNS gene therapy and a nexus of complexity: systems and biology at a crossroads.
- Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pa...
- Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems.
- Immune shaping and the development of Alzheimer's disease vaccines.
- Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia.
- HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses.
- Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from h...
- Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
- Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma.
- Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons.
- Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra.
- Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases.
- Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression.
- The role of the THY1 gene in human ovarian cancer suppression based on transfection studies.
- Neurotrophin secretory pathways and synaptic plasticity.
- Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system.
- p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.
- Current treatment for Alzheimer disease and future prospects.
- Convergent pathobiologic model of Parkinson's disease.
- Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing.
- Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS.
- Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity.
- HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia.
- Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer.
- Somatic mosaic approaches and the aging brain.
- Amyloid immunotherapy-engendered CNS inflammation.
- Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
- Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea.
- Reporter gene transfer induces apoptosis in primary cortical neurons.
- Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humora...
- Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.
- Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors.
- Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle.
- Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer.
- Cloning and Characterization of the Rat Gene Encoding GAP-43.
- Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.
- Immune Responses in Parkinson's Disease: Interplay between Central and Peripheral Immune Systems.
Schools
Albert Einstein College of Medicine of Yeshiva University
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Fellow
Education
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Massachusetts General Hospital -
Albert Einstein College of Medicine of Yeshiva University
Hospital
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MedStar Georgetown University Hospital
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