Chief, Division of Medicine-Pulmonary, Northwestern University Medical School
Pulmonology
Dr. Jacob I. Sznajder, MD
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Dr. Jacob I. Sznajder is an expert in the field of Pulmonology. He graduated from Northwestern University Feinberg School of Medicine. Northwestern University Feinberg School of Medicine has a rank of 19 in research and a 29 in primary care He over the years received 1 awards: "Super Doctor". Jacob I. Sznajder is a published MD as well. He has 101 publications published. The latest was: Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Publications
- Role of Linear Ubiquitination in Health and Disease.
- Suppression of Von Hippel-Lindau Protein in Fibroblasts Protects Against Bleomycin-induced Pulmonary Fibrosis.
- Muscle dysfunction in patients with lung diseases. A growing epidemic.
- Blue journal conference. Aging and susceptibility to lung disease.
- Corrigendum to "Calcium release-activated calcium (CRAC) channels mediate the β2 -adrenergic regulation of Na,K-ATPase" [FEBS Lett. 588 (24) (2014) 4686-4693].
- Calcium release-activated calcium (CRAC) channels mediate the β2-adrenergic regulation of Na,K-ATPase.
- Fitness to fly in patients with lung disease.
- Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury.
- NHLBI Workshop: Malfolded Protein Structure and Proteostasis in Lung Diseases.
- The Emerging Role of the Ubiquitin Proteasome in Pulmonary Biology and Disease.
- Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-?
- PKA I? Regulates Na,K-ATPase Endocytosis in Alveolar Epithelial Cells Exposed to High CO2 Levels.
- Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure.
- Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins.
- Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia.
- Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer.
- Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells.
- Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms.
- Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.
- Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells.
- Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.
- Mechanisms of Pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
- Scorpion venom decreases lung liquid clearance in rats.
- Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k.
- Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury.
- The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.
- Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance.
- beta(2)-Agonists for treatment of Pulmonary edema: ready for clinical studies?
- Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
- Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.
- Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.
- To live or die: a critical decision for the lung.
- Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-ind...
- FGF-10 prevents mechanical stretch-induced alveolar epithelial cell DNA damage via MAPK activation.
- Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2).
- Mechanisms of Pulmonary edema clearance.
- The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.
- Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
- Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.
- Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.
- Integrating acute lung injury and regulation of alveolar fluid clearance.
- Alveolar fluid reabsorption is increased in rats with compensated heart failure.
- Na,K-ATPase alpha1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane.
- The alveolar-epithelial barrier: a target for potential therapy.
- [Effect of changes in airway pressure and the inspiratory volume on the fluid filtration rate and Pulmonary artery pressure in isolated rabbit lungs perfused with bloo...
- Alveolar epithelium and Na,K-ATPase in acute lung injury.
- Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.
- Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.
- Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
- Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
- Regulation of Na,K-ATPase during acute lung injury.
- High CO2 levels impair alveolar epithelial function independently of pH.
- Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
- AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
- Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.
- Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans.
- Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.
- Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
- Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
- Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
- Myosin-Va restrains the trafficking of Na+/K+-ATPase-containing vesicles in alveolar epithelial cells.
- Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
- Hypoxic inhibition of alveolar fluid reabsorption.
- Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
- Role of ubiquitination in Na,K-ATPase regulation during lung injury.
- Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.
- [Permissive and non-permissive hypercapnia: mechanisms of action and consequences of high carbon dioxide levels].
- Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
- E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
- Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.
- Mitochondrial Ca²+ and ROS take center stage to orchestrate TNF-α-mediated inflammatory responses.
- Update in acute lung injury and critical care 2010.
- Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.
- Prompting Physicians to Address a Daily Checklist and Process of Care and Clinical Outcomes: A Single-Site Study.
- Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis.
- Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
- Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.
- Innate and adaptive immunity: the 2011 Nobel Prize in Physiology or Medicine.
- Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.
- Regulation of alveolar epithelial function by hypoxia.
- Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.
- PEEP is necessary for exogenous surfactant to reduce Pulmonary edema in canine aspiration pneumonitis.
- Beneficial effects of reducing Pulmonary edema in patients with acute hypoxemic respiratory failure.
- Differential activation of mixed venous and arterial neutrophils in patients with sepsis syndrome and acute lung injury.
- Effect of sodium azide on hydrogen peroxide production by zymosan-activated human neutrophils.
- Pathogenesis of Pulmonary edema associated with intracisternal endotoxin in dogs.
- Adverse effects of large tidal volume and low PEEP in canine acid aspiration.
- Dopamine increases lung liquid clearance during mechanical ventilation.
- Invited review: lung edema clearance: role of Na(+)-K(+)-ATPase.
- Distribution of Pulmonary vascular resistance during lactic acid infusion in dogs.
- The effect of hypopnea on low-pressure Pulmonary edema.
- Gas density dependence of regional VA/V and VA/Q inequality during constant-flow ventilation.
- Combination of constant-flow and continuous positive-pressure ventilation in canine Pulmonary edema.
- Measurement of hydrogen peroxide in plasma and blood.
- Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure.
- Alveolar pressure inhomogeneity and gas exchange during constant-flow ventilation in dogs.
- Constant flow ventilation in anesthetized patients: efficacy and safety.
- Ventilation-perfusion inequality during constant-flow ventilation.
- Lobar contribution to VA/Q inequality during constant-flow ventilation.
- Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Conditions Treated
- Pulmonary Embolism
Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
- Blue Card PPO
- Blue Cross Blue Shield of Illinois PPO
- Cigna HMO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Cofinity PPO
- HealthLink PPO
- Choice Care PPO
- Medicare MCR
- MultiPlan PPO
- PHCS Network PPO
- Principal Life
- Choice Plus POS
- Options PPO
- United Healthcare
Awards
- Super Doctor
Education
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Northwestern University Feinberg School of Medicine
Hospital
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Northwestern Memorial Hospital
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